<?xml version="1.0" encoding="UTF-8"?>
<!--XBRL document created by Certent CDM version: 22.2.0 using Fujitsu Interstage XWand -->
<linkbase xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/instance http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd" xmlns="http://www.xbrl.org/2003/linkbase" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xbrldt="http://xbrl.org/2005/xbrldt">
    <roleRef roleURI="http://fasb.org/us-gaap/role/eedm/ExtensibleEnumerationLists" xlink:type="simple" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-roles-2022.xsd#eedm" />
    <roleRef roleURI="http://www.uscentury.com/role/BorrowingsScheduleOfFixedInterestRatesAndExpectedMaturitiesDetails" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_BorrowingsScheduleOfFixedInterestRatesAndExpectedMaturitiesDetails" />
    <roleRef roleURI="http://www.uscentury.com/role/ConsolidatedBalanceSheets" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_ConsolidatedBalanceSheets" />
    <roleRef roleURI="http://www.uscentury.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_ConsolidatedBalanceSheetsParenthetical" />
    <roleRef roleURI="http://www.uscentury.com/role/ConsolidatedStatementsOfCashFlows" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_ConsolidatedStatementsOfCashFlows" />
    <roleRef roleURI="http://www.uscentury.com/role/ConsolidatedStatementsOfChangesInShareholdersEquity" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_ConsolidatedStatementsOfChangesInShareholdersEquity" />
    <roleRef roleURI="http://www.uscentury.com/role/ConsolidatedStatementsOfChangesInShareholdersEquityParenthetical" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_ConsolidatedStatementsOfChangesInShareholdersEquityParenthetical" />
    <roleRef roleURI="http://www.uscentury.com/role/ConsolidatedStatementsOfOperations" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_ConsolidatedStatementsOfOperations" />
    <roleRef roleURI="http://www.uscentury.com/role/DerivativesNarrativeDetails" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_DerivativesNarrativeDetails" />
    <roleRef roleURI="http://www.uscentury.com/role/DerivativesSummaryOfInterestRateSwapsDetails" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_DerivativesSummaryOfInterestRateSwapsDetails" />
    <roleRef roleURI="http://www.uscentury.com/role/EarningsPerShareCalculationOfBasicAndDilutedEarningsLossPerCommonShareClassDetails" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_EarningsPerShareCalculationOfBasicAndDilutedEarningsLossPerCommonShareClassDetails" />
    <roleRef roleURI="http://www.uscentury.com/role/EarningsPerShareNarrativeDetails" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_EarningsPerShareNarrativeDetails" />
    <roleRef roleURI="http://www.uscentury.com/role/EquityBasedAndOtherCompensationPlansNarrativeDetails" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_EquityBasedAndOtherCompensationPlansNarrativeDetails" />
    <roleRef roleURI="http://www.uscentury.com/role/EquityBasedAndOtherCompensationPlansScheduleOfStockOptionsActivityDetails" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_EquityBasedAndOtherCompensationPlansScheduleOfStockOptionsActivityDetails" />
    <roleRef roleURI="http://www.uscentury.com/role/EquityBasedAndOtherCompensationPlansScheduleOfStockOptionsValuationAssumptionsDetails" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_EquityBasedAndOtherCompensationPlansScheduleOfStockOptionsValuationAssumptionsDetails" />
    <roleRef roleURI="http://www.uscentury.com/role/FairValueMeasurementsCarryingAmountsAndEstimatedFairValuesOfFinancialInstrumentsNotCarriedAtFairValueDetails" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_FairValueMeasurementsCarryingAmountsAndEstimatedFairValuesOfFinancialInstrumentsNotCarriedAtFairValueDetails" />
    <roleRef roleURI="http://www.uscentury.com/role/FairValueMeasurementsNarrativeDetails" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_FairValueMeasurementsNarrativeDetails" />
    <roleRef roleURI="http://www.uscentury.com/role/FairValueMeasurementsQuantifiedInformationAboutLevel3FairValueMeasurementsForAssetsMeasuredAtFairValueOnANonrecurringBasisDetails" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_FairValueMeasurementsQuantifiedInformationAboutLevel3FairValueMeasurementsForAssetsMeasuredAtFairValueOnANonrecurringBasisDetails" />
    <roleRef roleURI="http://www.uscentury.com/role/FairValueMeasurementsScheduleOfAssetsMeasuredAtFairValueOnRecurringAndNonrecurringBasisDetails" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_FairValueMeasurementsScheduleOfAssetsMeasuredAtFairValueOnRecurringAndNonrecurringBasisDetails" />
    <roleRef roleURI="http://www.uscentury.com/role/IncomeTaxesNarrativeDetails" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_IncomeTaxesNarrativeDetails" />
    <roleRef roleURI="http://www.uscentury.com/role/InvestmentSecuritiesAmortizedCostAndFairValueOfInvestmentSecuritiesByContractualMaturityDateDetails" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_InvestmentSecuritiesAmortizedCostAndFairValueOfInvestmentSecuritiesByContractualMaturityDateDetails" />
    <roleRef roleURI="http://www.uscentury.com/role/InvestmentSecuritiesAvailableforSaleSecuritiesContinuousUnrealizedLossPositionFairValueDetails" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_InvestmentSecuritiesAvailableforSaleSecuritiesContinuousUnrealizedLossPositionFairValueDetails" />
    <roleRef roleURI="http://www.uscentury.com/role/InvestmentSecuritiesNarrativeDetails" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_InvestmentSecuritiesNarrativeDetails" />
    <roleRef roleURI="http://www.uscentury.com/role/InvestmentSecuritiesScheduleOfAvailableforsaleSecuritiesAndHeldtomaturitySecuritiesReconciliationDetails" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_InvestmentSecuritiesScheduleOfAvailableforsaleSecuritiesAndHeldtomaturitySecuritiesReconciliationDetails" />
    <roleRef roleURI="http://www.uscentury.com/role/LoansAgingAnalysisOfAccruingAndTotalNonAccruingLoansDetails" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_LoansAgingAnalysisOfAccruingAndTotalNonAccruingLoansDetails" />
    <roleRef roleURI="http://www.uscentury.com/role/LoansAllowanceForCreditLossesDetails" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_LoansAllowanceForCreditLossesDetails" />
    <roleRef roleURI="http://www.uscentury.com/role/LoansImpairedLoansDetails" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_LoansImpairedLoansDetails" />
    <roleRef roleURI="http://www.uscentury.com/role/LoansLoanCreditExposuresDetails" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_LoansLoanCreditExposuresDetails" />
    <roleRef roleURI="http://www.uscentury.com/role/LoansNarrativeDetails" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_LoansNarrativeDetails" />
    <roleRef roleURI="http://www.uscentury.com/role/LoansPerformingAndNonPerformingTroubledDebtRestructuringsDetails" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_LoansPerformingAndNonPerformingTroubledDebtRestructuringsDetails" />
    <roleRef roleURI="http://www.uscentury.com/role/LoansSummaryOfLoansHeldForInvestmentDetails" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_LoansSummaryOfLoansHeldForInvestmentDetails" />
    <roleRef roleURI="http://www.uscentury.com/role/LoansTroubledDebtRestructuringLoansDetails" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_LoansTroubledDebtRestructuringLoansDetails" />
    <roleRef roleURI="http://www.uscentury.com/role/OffBalanceSheetArrangementsScheduleOfFinancialsInstrumentsWithOffBalanceSheetRiskDetails" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_OffBalanceSheetArrangementsScheduleOfFinancialsInstrumentsWithOffBalanceSheetRiskDetails" />
    <roleRef roleURI="http://www.uscentury.com/role/ParentCompanyCondensedFinancialInformationScheduleOfCashFlowDetails" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_ParentCompanyCondensedFinancialInformationScheduleOfCashFlowDetails" />
    <roleRef roleURI="http://www.uscentury.com/role/ParentCompanyCondensedFinancialInformationScheduleOfCondensedBalanceSheetsDetails" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_ParentCompanyCondensedFinancialInformationScheduleOfCondensedBalanceSheetsDetails" />
    <roleRef roleURI="http://www.uscentury.com/role/ParentCompanyCondensedFinancialInformationScheduleOfIncomeStatementDetails" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_ParentCompanyCondensedFinancialInformationScheduleOfIncomeStatementDetails" />
    <roleRef roleURI="http://www.uscentury.com/role/PremisesAndEquipmentNarrativeDetails" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_PremisesAndEquipmentNarrativeDetails" />
    <roleRef roleURI="http://www.uscentury.com/role/PremisesAndEquipmentSummaryOfPremisesAndEquipmentDetails" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_PremisesAndEquipmentSummaryOfPremisesAndEquipmentDetails" />
    <roleRef roleURI="http://www.uscentury.com/role/RegulatoryMattersNarrativeDetails" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_RegulatoryMattersNarrativeDetails" />
    <roleRef roleURI="http://www.uscentury.com/role/RegulatoryMattersScheduleOfActualCapitalAmountsAndRatiosDetails" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_RegulatoryMattersScheduleOfActualCapitalAmountsAndRatiosDetails" />
    <roleRef roleURI="http://www.uscentury.com/role/RelatedPartyTransactionsNarrativeDetails" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_RelatedPartyTransactionsNarrativeDetails" />
    <roleRef roleURI="http://www.uscentury.com/role/StockholdersEquityNarrativeDetails" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_StockholdersEquityNarrativeDetails" />
    <roleRef roleURI="http://www.uscentury.com/role/StockholdersEquityScheduleOfDividendsOnPreferredSharesDetails" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_StockholdersEquityScheduleOfDividendsOnPreferredSharesDetails" />
    <roleRef roleURI="http://www.uscentury.com/role/SubsequentEventsNarrativeDetails" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_SubsequentEventsNarrativeDetails" />
    <roleRef roleURI="http://www.uscentury.com/role/SummaryOfSignificantAccountingPoliciesNarrativeDetails" xlink:type="simple" xlink:href="uscb-20221231.xsd#ELRID_SummaryOfSignificantAccountingPoliciesNarrativeDetails" />
    <arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all" />
    <arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default" />
    <arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain" />
    <arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member" />
    <arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension" />
    <definitionLink xlink:type="extended" xlink:role="http://fasb.org/us-gaap/role/eedm/ExtensibleEnumerationLists">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAbstract" xlink:label="Locator_us-gaap_LiabilitiesAbstract_1" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_AccruedInterestAndOtherLiabilities" xlink:label="Locator_uscb_AccruedInterestAndOtherLiabilities_2" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_LiabilitiesAbstract_1" xlink:to="Locator_uscb_AccruedInterestAndOtherLiabilities_2" order="30.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/ConsolidatedStatementsOfOperations">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable" xlink:label="Locator_us-gaap_StatementTable_235" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="Locator_us-gaap_StatementClassOfStockAxis_236" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_StatementTable_235" xlink:to="Locator_us-gaap_StatementClassOfStockAxis_236" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="Locator_us-gaap_StatementClassOfStockAxis_237" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_238" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_StatementClassOfStockAxis_237" xlink:to="Locator_us-gaap_ClassOfStockDomain_238" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_241" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassBMember" xlink:label="Locator_us-gaap_CommonClassBMember_242" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockDomain_241" xlink:to="Locator_us-gaap_CommonClassBMember_242" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_239" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassAMember" xlink:label="Locator_us-gaap_CommonClassAMember_240" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockDomain_239" xlink:to="Locator_us-gaap_CommonClassAMember_240" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_243" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareAbstract" xlink:label="Locator_us-gaap_EarningsPerShareAbstract_244" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_243" xlink:to="Locator_us-gaap_EarningsPerShareAbstract_244" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareAbstract" xlink:label="Locator_us-gaap_EarningsPerShareAbstract_245" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareBasic" xlink:label="Locator_us-gaap_EarningsPerShareBasic_246" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_EarningsPerShareAbstract_245" xlink:to="Locator_us-gaap_EarningsPerShareBasic_246" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareAbstract" xlink:label="Locator_us-gaap_EarningsPerShareAbstract_247" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareDiluted" xlink:label="Locator_us-gaap_EarningsPerShareDiluted_248" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_EarningsPerShareAbstract_247" xlink:to="Locator_us-gaap_EarningsPerShareDiluted_248" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_163" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable" xlink:label="Locator_us-gaap_StatementTable_164" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_us-gaap_StatementLineItems_163" xlink:to="Locator_us-gaap_StatementTable_164" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/ConsolidatedBalanceSheets">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsAbstract" xlink:label="Locator_us-gaap_AssetsAbstract_419" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndDueFromBanks" xlink:label="Locator_us-gaap_CashAndDueFromBanks_420" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AssetsAbstract_419" xlink:to="Locator_us-gaap_CashAndDueFromBanks_420" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsAbstract" xlink:label="Locator_us-gaap_AssetsAbstract_421" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestBearingDepositsInBanks" xlink:label="Locator_us-gaap_InterestBearingDepositsInBanks_422" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AssetsAbstract_421" xlink:to="Locator_us-gaap_InterestBearingDepositsInBanks_422" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsAbstract" xlink:label="Locator_us-gaap_AssetsAbstract_423" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="Locator_us-gaap_CashAndCashEquivalentsAtCarryingValue_424" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AssetsAbstract_423" xlink:to="Locator_us-gaap_CashAndCashEquivalentsAtCarryingValue_424" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsAbstract" xlink:label="Locator_us-gaap_AssetsAbstract_425" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesHeldToMaturityAmortizedCostAfterAllowanceForCreditLoss" xlink:label="Locator_us-gaap_DebtSecuritiesHeldToMaturityAmortizedCostAfterAllowanceForCreditLoss_426" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AssetsAbstract_425" xlink:to="Locator_us-gaap_DebtSecuritiesHeldToMaturityAmortizedCostAfterAllowanceForCreditLoss_426" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsAbstract" xlink:label="Locator_us-gaap_AssetsAbstract_427" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:label="Locator_us-gaap_AvailableForSaleSecuritiesDebtSecurities_428" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AssetsAbstract_427" xlink:to="Locator_us-gaap_AvailableForSaleSecuritiesDebtSecurities_428" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsAbstract" xlink:label="Locator_us-gaap_AssetsAbstract_429" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FederalHomeLoanBankStock" xlink:label="Locator_us-gaap_FederalHomeLoanBankStock_430" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AssetsAbstract_429" xlink:to="Locator_us-gaap_FederalHomeLoanBankStock_430" order="6.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsAbstract" xlink:label="Locator_us-gaap_AssetsAbstract_431" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LoansAndLeasesReceivableNetReportedAmount" xlink:label="Locator_us-gaap_LoansAndLeasesReceivableNetReportedAmount_432" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AssetsAbstract_431" xlink:to="Locator_us-gaap_LoansAndLeasesReceivableNetReportedAmount_432" order="7.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsAbstract" xlink:label="Locator_us-gaap_AssetsAbstract_433" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestReceivable" xlink:label="Locator_us-gaap_InterestReceivable_434" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AssetsAbstract_433" xlink:to="Locator_us-gaap_InterestReceivable_434" order="8.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsAbstract" xlink:label="Locator_us-gaap_AssetsAbstract_435" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="Locator_us-gaap_PropertyPlantAndEquipmentNet_436" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AssetsAbstract_435" xlink:to="Locator_us-gaap_PropertyPlantAndEquipmentNet_436" order="9.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsAbstract" xlink:label="Locator_us-gaap_AssetsAbstract_437" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsHeldForSaleNotPartOfDisposalGroup" xlink:label="Locator_us-gaap_AssetsHeldForSaleNotPartOfDisposalGroup_438" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AssetsAbstract_437" xlink:to="Locator_us-gaap_AssetsHeldForSaleNotPartOfDisposalGroup_438" order="10.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsAbstract" xlink:label="Locator_us-gaap_AssetsAbstract_439" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BankOwnedLifeInsurance" xlink:label="Locator_us-gaap_BankOwnedLifeInsurance_440" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AssetsAbstract_439" xlink:to="Locator_us-gaap_BankOwnedLifeInsurance_440" order="11.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsAbstract" xlink:label="Locator_us-gaap_AssetsAbstract_441" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DeferredIncomeTaxAssetsNet" xlink:label="Locator_us-gaap_DeferredIncomeTaxAssetsNet_442" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AssetsAbstract_441" xlink:to="Locator_us-gaap_DeferredIncomeTaxAssetsNet_442" order="12.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsAbstract" xlink:label="Locator_us-gaap_AssetsAbstract_443" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseRightOfUseAsset" xlink:label="Locator_us-gaap_OperatingLeaseRightOfUseAsset_444" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AssetsAbstract_443" xlink:to="Locator_us-gaap_OperatingLeaseRightOfUseAsset_444" order="13.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsAbstract" xlink:label="Locator_us-gaap_AssetsAbstract_445" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAssets" xlink:label="Locator_us-gaap_OtherAssets_446" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AssetsAbstract_445" xlink:to="Locator_us-gaap_OtherAssets_446" order="14.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsAbstract" xlink:label="Locator_us-gaap_AssetsAbstract_447" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Assets" xlink:label="Locator_us-gaap_Assets_448" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AssetsAbstract_447" xlink:to="Locator_us-gaap_Assets_448" order="15.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAbstract" xlink:label="Locator_us-gaap_LiabilitiesAbstract_453" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DepositsAbstract" xlink:label="Locator_us-gaap_DepositsAbstract_454" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_LiabilitiesAbstract_453" xlink:to="Locator_us-gaap_DepositsAbstract_454" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DepositsAbstract" xlink:label="Locator_us-gaap_DepositsAbstract_455" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DemandDepositAccounts" xlink:label="Locator_us-gaap_DemandDepositAccounts_456" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_DepositsAbstract_455" xlink:to="Locator_us-gaap_DemandDepositAccounts_456" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DepositsAbstract" xlink:label="Locator_us-gaap_DepositsAbstract_457" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DepositsMoneyMarketAndSavingsDeposits" xlink:label="Locator_uscb_DepositsMoneyMarketAndSavingsDeposits_458" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_DepositsAbstract_457" xlink:to="Locator_uscb_DepositsMoneyMarketAndSavingsDeposits_458" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DepositsAbstract" xlink:label="Locator_us-gaap_DepositsAbstract_459" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestBearingDepositLiabilities" xlink:label="Locator_us-gaap_InterestBearingDepositLiabilities_460" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_DepositsAbstract_459" xlink:to="Locator_us-gaap_InterestBearingDepositLiabilities_460" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DepositsAbstract" xlink:label="Locator_us-gaap_DepositsAbstract_461" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TimeDeposits" xlink:label="Locator_us-gaap_TimeDeposits_462" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_DepositsAbstract_461" xlink:to="Locator_us-gaap_TimeDeposits_462" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DepositsAbstract" xlink:label="Locator_us-gaap_DepositsAbstract_463" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_TimeDeposits250000OrMore" xlink:label="Locator_uscb_TimeDeposits250000OrMore_464" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_DepositsAbstract_463" xlink:to="Locator_uscb_TimeDeposits250000OrMore_464" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DepositsAbstract" xlink:label="Locator_us-gaap_DepositsAbstract_465" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_TimeDepositsLessThan250000" xlink:label="Locator_uscb_TimeDepositsLessThan250000_466" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_DepositsAbstract_465" xlink:to="Locator_uscb_TimeDepositsLessThan250000_466" order="6.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DepositsAbstract" xlink:label="Locator_us-gaap_DepositsAbstract_467" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Deposits" xlink:label="Locator_us-gaap_Deposits_468" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_DepositsAbstract_467" xlink:to="Locator_us-gaap_Deposits_468" order="7.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAbstract" xlink:label="Locator_us-gaap_LiabilitiesAbstract_469" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_AdvancesFederalHomeLoanBank" xlink:label="Locator_uscb_AdvancesFederalHomeLoanBank_470" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_LiabilitiesAbstract_469" xlink:to="Locator_uscb_AdvancesFederalHomeLoanBank_470" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAbstract" xlink:label="Locator_us-gaap_LiabilitiesAbstract_471" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiability" xlink:label="Locator_us-gaap_OperatingLeaseLiability_472" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_LiabilitiesAbstract_471" xlink:to="Locator_us-gaap_OperatingLeaseLiability_472" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAbstract" xlink:label="Locator_us-gaap_LiabilitiesAbstract_473" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_AccruedInterestAndOtherLiabilities" xlink:label="Locator_uscb_AccruedInterestAndOtherLiabilities_474" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_LiabilitiesAbstract_473" xlink:to="Locator_uscb_AccruedInterestAndOtherLiabilities_474" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAbstract" xlink:label="Locator_us-gaap_LiabilitiesAbstract_475" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Liabilities" xlink:label="Locator_us-gaap_Liabilities_476" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_LiabilitiesAbstract_475" xlink:to="Locator_us-gaap_Liabilities_476" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable" xlink:label="Locator_us-gaap_StatementTable_403" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="Locator_us-gaap_StatementClassOfStockAxis_404" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_StatementTable_403" xlink:to="Locator_us-gaap_StatementClassOfStockAxis_404" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="Locator_us-gaap_StatementClassOfStockAxis_405" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_406" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_StatementClassOfStockAxis_405" xlink:to="Locator_us-gaap_ClassOfStockDomain_406" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_415" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassBMember" xlink:label="Locator_us-gaap_CommonClassBMember_416" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockDomain_415" xlink:to="Locator_us-gaap_CommonClassBMember_416" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_407" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SeriesCPreferredStockMember" xlink:label="Locator_us-gaap_SeriesCPreferredStockMember_408" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockDomain_407" xlink:to="Locator_us-gaap_SeriesCPreferredStockMember_408" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_409" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SeriesDPreferredStockMember" xlink:label="Locator_us-gaap_SeriesDPreferredStockMember_410" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockDomain_409" xlink:to="Locator_us-gaap_SeriesDPreferredStockMember_410" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_411" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SeriesEPreferredStockMember" xlink:label="Locator_us-gaap_SeriesEPreferredStockMember_412" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockDomain_411" xlink:to="Locator_us-gaap_SeriesEPreferredStockMember_412" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_413" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassAMember" xlink:label="Locator_us-gaap_CommonClassAMember_414" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockDomain_413" xlink:to="Locator_us-gaap_CommonClassAMember_414" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_417" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsAbstract" xlink:label="Locator_us-gaap_AssetsAbstract_418" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_417" xlink:to="Locator_us-gaap_AssetsAbstract_418" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_449" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract" xlink:label="Locator_us-gaap_LiabilitiesAndStockholdersEquityAbstract_450" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_449" xlink:to="Locator_us-gaap_LiabilitiesAndStockholdersEquityAbstract_450" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract" xlink:label="Locator_us-gaap_LiabilitiesAndStockholdersEquityAbstract_451" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAbstract" xlink:label="Locator_us-gaap_LiabilitiesAbstract_452" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_LiabilitiesAndStockholdersEquityAbstract_451" xlink:to="Locator_us-gaap_LiabilitiesAbstract_452" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract" xlink:label="Locator_us-gaap_LiabilitiesAndStockholdersEquityAbstract_477" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingencies" xlink:label="Locator_us-gaap_CommitmentsAndContingencies_478" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_LiabilitiesAndStockholdersEquityAbstract_477" xlink:to="Locator_us-gaap_CommitmentsAndContingencies_478" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract" xlink:label="Locator_us-gaap_LiabilitiesAndStockholdersEquityAbstract_479" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityAbstract" xlink:label="Locator_us-gaap_StockholdersEquityAbstract_480" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_LiabilitiesAndStockholdersEquityAbstract_479" xlink:to="Locator_us-gaap_StockholdersEquityAbstract_480" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityAbstract" xlink:label="Locator_us-gaap_StockholdersEquityAbstract_481" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockValue" xlink:label="Locator_us-gaap_PreferredStockValue_482" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StockholdersEquityAbstract_481" xlink:to="Locator_us-gaap_PreferredStockValue_482" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityAbstract" xlink:label="Locator_us-gaap_StockholdersEquityAbstract_483" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockValue" xlink:label="Locator_us-gaap_CommonStockValue_484" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StockholdersEquityAbstract_483" xlink:to="Locator_us-gaap_CommonStockValue_484" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityAbstract" xlink:label="Locator_us-gaap_StockholdersEquityAbstract_485" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdditionalPaidInCapital" xlink:label="Locator_us-gaap_AdditionalPaidInCapital_486" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StockholdersEquityAbstract_485" xlink:to="Locator_us-gaap_AdditionalPaidInCapital_486" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityAbstract" xlink:label="Locator_us-gaap_StockholdersEquityAbstract_487" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="Locator_us-gaap_RetainedEarningsAccumulatedDeficit_488" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StockholdersEquityAbstract_487" xlink:to="Locator_us-gaap_RetainedEarningsAccumulatedDeficit_488" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityAbstract" xlink:label="Locator_us-gaap_StockholdersEquityAbstract_489" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:label="Locator_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_490" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StockholdersEquityAbstract_489" xlink:to="Locator_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_490" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityAbstract" xlink:label="Locator_us-gaap_StockholdersEquityAbstract_491" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity" xlink:label="Locator_us-gaap_StockholdersEquity_492" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StockholdersEquityAbstract_491" xlink:to="Locator_us-gaap_StockholdersEquity_492" order="6.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract" xlink:label="Locator_us-gaap_LiabilitiesAndStockholdersEquityAbstract_493" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="Locator_us-gaap_LiabilitiesAndStockholdersEquity_494" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_LiabilitiesAndStockholdersEquityAbstract_493" xlink:to="Locator_us-gaap_LiabilitiesAndStockholdersEquity_494" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_263" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable" xlink:label="Locator_us-gaap_StatementTable_264" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_us-gaap_StatementLineItems_263" xlink:to="Locator_us-gaap_StatementTable_264" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/ConsolidatedBalanceSheetsParenthetical">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable" xlink:label="Locator_us-gaap_StatementTable_537" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="Locator_us-gaap_StatementClassOfStockAxis_538" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_StatementTable_537" xlink:to="Locator_us-gaap_StatementClassOfStockAxis_538" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="Locator_us-gaap_StatementClassOfStockAxis_539" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_540" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_StatementClassOfStockAxis_539" xlink:to="Locator_us-gaap_ClassOfStockDomain_540" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="Locator_us-gaap_StatementClassOfStockAxis_573" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_574" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_us-gaap_StatementClassOfStockAxis_573" xlink:to="Locator_us-gaap_ClassOfStockDomain_574" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_549" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassBMember" xlink:label="Locator_us-gaap_CommonClassBMember_550" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockDomain_549" xlink:to="Locator_us-gaap_CommonClassBMember_550" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_541" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SeriesCPreferredStockMember" xlink:label="Locator_us-gaap_SeriesCPreferredStockMember_542" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockDomain_541" xlink:to="Locator_us-gaap_SeriesCPreferredStockMember_542" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_543" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SeriesDPreferredStockMember" xlink:label="Locator_us-gaap_SeriesDPreferredStockMember_544" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockDomain_543" xlink:to="Locator_us-gaap_SeriesDPreferredStockMember_544" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_545" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SeriesEPreferredStockMember" xlink:label="Locator_us-gaap_SeriesEPreferredStockMember_546" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockDomain_545" xlink:to="Locator_us-gaap_SeriesEPreferredStockMember_546" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_547" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassAMember" xlink:label="Locator_us-gaap_CommonClassAMember_548" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockDomain_547" xlink:to="Locator_us-gaap_CommonClassAMember_548" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_551" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecuritiesFairValue" xlink:label="Locator_us-gaap_HeldToMaturitySecuritiesFairValue_552" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_551" xlink:to="Locator_us-gaap_HeldToMaturitySecuritiesFairValue_552" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_553" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LoansAndLeasesReceivableAllowance" xlink:label="Locator_us-gaap_LoansAndLeasesReceivableAllowance_554" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_553" xlink:to="Locator_us-gaap_LoansAndLeasesReceivableAllowance_554" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_555" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockParOrStatedValuePerShare" xlink:label="Locator_us-gaap_PreferredStockParOrStatedValuePerShare_556" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_555" xlink:to="Locator_us-gaap_PreferredStockParOrStatedValuePerShare_556" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_557" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockLiquidationPreference" xlink:label="Locator_us-gaap_PreferredStockLiquidationPreference_558" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_557" xlink:to="Locator_us-gaap_PreferredStockLiquidationPreference_558" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_559" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockSharesAuthorized" xlink:label="Locator_us-gaap_PreferredStockSharesAuthorized_560" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_559" xlink:to="Locator_us-gaap_PreferredStockSharesAuthorized_560" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_561" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockSharesIssued" xlink:label="Locator_us-gaap_PreferredStockSharesIssued_562" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_561" xlink:to="Locator_us-gaap_PreferredStockSharesIssued_562" order="6.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_563" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockSharesOutstanding" xlink:label="Locator_us-gaap_PreferredStockSharesOutstanding_564" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_563" xlink:to="Locator_us-gaap_PreferredStockSharesOutstanding_564" order="7.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_565" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockParOrStatedValuePerShare" xlink:label="Locator_us-gaap_CommonStockParOrStatedValuePerShare_566" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_565" xlink:to="Locator_us-gaap_CommonStockParOrStatedValuePerShare_566" order="8.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_567" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesAuthorized" xlink:label="Locator_us-gaap_CommonStockSharesAuthorized_568" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_567" xlink:to="Locator_us-gaap_CommonStockSharesAuthorized_568" order="9.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_569" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesIssued" xlink:label="Locator_us-gaap_CommonStockSharesIssued_570" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_569" xlink:to="Locator_us-gaap_CommonStockSharesIssued_570" order="10.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_571" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesOutstanding" xlink:label="Locator_us-gaap_CommonStockSharesOutstanding_572" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_571" xlink:to="Locator_us-gaap_CommonStockSharesOutstanding_572" order="11.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_533" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable" xlink:label="Locator_us-gaap_StatementTable_534" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_us-gaap_StatementLineItems_533" xlink:to="Locator_us-gaap_StatementTable_534" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/ConsolidatedStatementsOfCashFlows">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable" xlink:label="Locator_us-gaap_StatementTable_775" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="Locator_us-gaap_StatementClassOfStockAxis_776" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_StatementTable_775" xlink:to="Locator_us-gaap_StatementClassOfStockAxis_776" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="Locator_us-gaap_StatementClassOfStockAxis_777" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_778" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_StatementClassOfStockAxis_777" xlink:to="Locator_us-gaap_ClassOfStockDomain_778" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_785" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassBMember" xlink:label="Locator_us-gaap_CommonClassBMember_786" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockDomain_785" xlink:to="Locator_us-gaap_CommonClassBMember_786" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_779" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SeriesCPreferredStockMember" xlink:label="Locator_us-gaap_SeriesCPreferredStockMember_780" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockDomain_779" xlink:to="Locator_us-gaap_SeriesCPreferredStockMember_780" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_781" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SeriesDPreferredStockMember" xlink:label="Locator_us-gaap_SeriesDPreferredStockMember_782" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockDomain_781" xlink:to="Locator_us-gaap_SeriesDPreferredStockMember_782" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_783" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SeriesEPreferredStockMember" xlink:label="Locator_us-gaap_SeriesEPreferredStockMember_784" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockDomain_783" xlink:to="Locator_us-gaap_SeriesEPreferredStockMember_784" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_787" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_788" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_787" xlink:to="Locator_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_788" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_791" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="Locator_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_792" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_791" xlink:to="Locator_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_792" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="Locator_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_793" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProvisionForLoanAndLeaseLosses" xlink:label="Locator_us-gaap_ProvisionForLoanAndLeaseLosses_794" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_793" xlink:to="Locator_us-gaap_ProvisionForLoanAndLeaseLosses_794" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="Locator_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_795" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DepreciationAndAmortization1" xlink:label="Locator_uscb_DepreciationAndAmortization1_796" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_795" xlink:to="Locator_uscb_DepreciationAndAmortization1_796" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="Locator_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_797" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments" xlink:label="Locator_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_798" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_797" xlink:to="Locator_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_798" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="Locator_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_799" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AmortizationOfDeferredLoanOriginationFeesNet" xlink:label="Locator_us-gaap_AmortizationOfDeferredLoanOriginationFeesNet_800" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_799" xlink:to="Locator_us-gaap_AmortizationOfDeferredLoanOriginationFeesNet_800" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="Locator_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_801" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensation" xlink:label="Locator_us-gaap_ShareBasedCompensation_802" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_801" xlink:to="Locator_us-gaap_ShareBasedCompensation_802" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="Locator_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_803" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleRealizedGainLoss" xlink:label="Locator_us-gaap_DebtSecuritiesAvailableForSaleRealizedGainLoss_804" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_803" xlink:to="Locator_us-gaap_DebtSecuritiesAvailableForSaleRealizedGainLoss_804" order="6.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="Locator_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_805" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GainLossOnSalesOfLoansNet" xlink:label="Locator_us-gaap_GainLossOnSalesOfLoansNet_806" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_805" xlink:to="Locator_us-gaap_GainLossOnSalesOfLoansNet_806" order="7.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="Locator_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_807" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GainLossOnSaleOfPropertyPlantEquipment" xlink:label="Locator_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_808" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_807" xlink:to="Locator_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_808" order="8.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="Locator_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_809" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BankOwnedLifeInsuranceIncome" xlink:label="Locator_us-gaap_BankOwnedLifeInsuranceIncome_810" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_809" xlink:to="Locator_us-gaap_BankOwnedLifeInsuranceIncome_810" order="9.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="Locator_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_811" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_IncreaseDecreaseInDeferredTaxAssets" xlink:label="Locator_uscb_IncreaseDecreaseInDeferredTaxAssets_812" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_811" xlink:to="Locator_uscb_IncreaseDecreaseInDeferredTaxAssets_812" order="10.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_813" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOperatingCapitalAbstract" xlink:label="Locator_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_814" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_813" xlink:to="Locator_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_814" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOperatingCapitalAbstract" xlink:label="Locator_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_815" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccruedInterestReceivableNet" xlink:label="Locator_us-gaap_IncreaseDecreaseInAccruedInterestReceivableNet_816" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_815" xlink:to="Locator_us-gaap_IncreaseDecreaseInAccruedInterestReceivableNet_816" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOperatingCapitalAbstract" xlink:label="Locator_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_817" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOtherOperatingAssets" xlink:label="Locator_us-gaap_IncreaseDecreaseInOtherOperatingAssets_818" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_817" xlink:to="Locator_us-gaap_IncreaseDecreaseInOtherOperatingAssets_818" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOperatingCapitalAbstract" xlink:label="Locator_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_819" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_IncreaseDecreaseInAccruedInterestAndOtherLiabilities" xlink:label="Locator_uscb_IncreaseDecreaseInAccruedInterestAndOtherLiabilities_820" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_819" xlink:to="Locator_uscb_IncreaseDecreaseInAccruedInterestAndOtherLiabilities_820" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_789" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss" xlink:label="Locator_us-gaap_NetIncomeLoss_790" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_789" xlink:to="Locator_us-gaap_NetIncomeLoss_790" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_821" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInOperatingActivities_822" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_821" xlink:to="Locator_us-gaap_NetCashProvidedByUsedInOperatingActivities_822" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_823" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_824" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_823" xlink:to="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_824" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_825" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireHeldToMaturitySecurities" xlink:label="Locator_us-gaap_PaymentsToAcquireHeldToMaturitySecurities_826" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_825" xlink:to="Locator_us-gaap_PaymentsToAcquireHeldToMaturitySecurities_826" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_827" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfHeldToMaturitySecurities" xlink:label="Locator_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfHeldToMaturitySecurities_828" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_827" xlink:to="Locator_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfHeldToMaturitySecurities_828" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_829" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt" xlink:label="Locator_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_830" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_829" xlink:to="Locator_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_830" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_831" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_ProceedsFromMaturitiesAndPrepaymentsOfAvailableForSaleSecurities" xlink:label="Locator_uscb_ProceedsFromMaturitiesAndPrepaymentsOfAvailableForSaleSecurities_832" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_831" xlink:to="Locator_uscb_ProceedsFromMaturitiesAndPrepaymentsOfAvailableForSaleSecurities_832" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_833" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt" xlink:label="Locator_us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt_834" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_833" xlink:to="Locator_us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt_834" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_835" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_ProceedsFromCallsOfDebtSecuritiesAvailableForSale" xlink:label="Locator_uscb_ProceedsFromCallsOfDebtSecuritiesAvailableForSale_836" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_835" xlink:to="Locator_uscb_ProceedsFromCallsOfDebtSecuritiesAvailableForSale_836" order="6.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_837" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsForProceedsFromOtherLoansAndLeases" xlink:label="Locator_us-gaap_PaymentsForProceedsFromOtherLoansAndLeases_838" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_837" xlink:to="Locator_us-gaap_PaymentsForProceedsFromOtherLoansAndLeases_838" order="7.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_839" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireLoansAndLeasesHeldForInvestment" xlink:label="Locator_us-gaap_PaymentsToAcquireLoansAndLeasesHeldForInvestment_840" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_839" xlink:to="Locator_us-gaap_PaymentsToAcquireLoansAndLeasesHeldForInvestment_840" order="8.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_841" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment" xlink:label="Locator_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_842" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_841" xlink:to="Locator_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_842" order="9.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_843" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_ProceedsFromSaleOfLoansHeldForSaleInvestingActivities" xlink:label="Locator_uscb_ProceedsFromSaleOfLoansHeldForSaleInvestingActivities_844" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_843" xlink:to="Locator_uscb_ProceedsFromSaleOfLoansHeldForSaleInvestingActivities_844" order="10.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_845" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment" xlink:label="Locator_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_846" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_845" xlink:to="Locator_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_846" order="11.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_847" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromSaleOfFederalHomeLoanBankStock" xlink:label="Locator_us-gaap_ProceedsFromSaleOfFederalHomeLoanBankStock_848" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_847" xlink:to="Locator_us-gaap_ProceedsFromSaleOfFederalHomeLoanBankStock_848" order="12.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_849" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireFederalHomeLoanBankStock" xlink:label="Locator_us-gaap_PaymentsToAcquireFederalHomeLoanBankStock_850" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_849" xlink:to="Locator_us-gaap_PaymentsToAcquireFederalHomeLoanBankStock_850" order="13.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_851" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireLifeInsurancePolicies" xlink:label="Locator_us-gaap_PaymentsToAcquireLifeInsurancePolicies_852" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_851" xlink:to="Locator_us-gaap_PaymentsToAcquireLifeInsurancePolicies_852" order="14.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_853" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivities_854" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_853" xlink:to="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivities_854" order="15.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_855" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_856" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_855" xlink:to="Locator_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_856" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_857" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock" xlink:label="Locator_us-gaap_ProceedsFromIssuanceOfCommonStock_858" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_857" xlink:to="Locator_us-gaap_ProceedsFromIssuanceOfCommonStock_858" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_861" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsForRepurchaseOfRedeemablePreferredStock" xlink:label="Locator_us-gaap_PaymentsForRepurchaseOfRedeemablePreferredStock_862" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_861" xlink:to="Locator_us-gaap_PaymentsForRepurchaseOfRedeemablePreferredStock_862" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_863" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInDeposits" xlink:label="Locator_us-gaap_IncreaseDecreaseInDeposits_864" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_863" xlink:to="Locator_us-gaap_IncreaseDecreaseInDeposits_864" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_865" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_ProceedsFromFederalHomeLoanBankAdvances1" xlink:label="Locator_uscb_ProceedsFromFederalHomeLoanBankAdvances1_866" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_865" xlink:to="Locator_uscb_ProceedsFromFederalHomeLoanBankAdvances1_866" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_867" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_RepaymentsOnFederalHomeLoanBankAdvances" xlink:label="Locator_uscb_RepaymentsOnFederalHomeLoanBankAdvances_868" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_867" xlink:to="Locator_uscb_RepaymentsOnFederalHomeLoanBankAdvances_868" order="6.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_859" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsOfDividends" xlink:label="Locator_us-gaap_PaymentsOfDividends_860" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_859" xlink:to="Locator_us-gaap_PaymentsOfDividends_860" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_869" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInFinancingActivities_870" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_869" xlink:to="Locator_us-gaap_NetCashProvidedByUsedInFinancingActivities_870" order="7.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_871" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" xlink:label="Locator_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_872" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_871" xlink:to="Locator_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_872" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_873" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:label="Locator_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_874" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_873" xlink:to="Locator_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_874" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_875" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SupplementalCashFlowInformationAbstract" xlink:label="Locator_us-gaap_SupplementalCashFlowInformationAbstract_876" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_875" xlink:to="Locator_us-gaap_SupplementalCashFlowInformationAbstract_876" order="7.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SupplementalCashFlowInformationAbstract" xlink:label="Locator_us-gaap_SupplementalCashFlowInformationAbstract_877" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestPaidNet" xlink:label="Locator_us-gaap_InterestPaidNet_878" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_SupplementalCashFlowInformationAbstract_877" xlink:to="Locator_us-gaap_InterestPaidNet_878" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_879" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NoncashInvestingAndFinancingItemsAbstract" xlink:label="Locator_us-gaap_NoncashInvestingAndFinancingItemsAbstract_880" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_879" xlink:to="Locator_us-gaap_NoncashInvestingAndFinancingItemsAbstract_880" order="8.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NoncashInvestingAndFinancingItemsAbstract" xlink:label="Locator_us-gaap_NoncashInvestingAndFinancingItemsAbstract_881" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransferOfPortfolioLoansAndLeasesToHeldForSale1" xlink:label="Locator_us-gaap_TransferOfPortfolioLoansAndLeasesToHeldForSale1_882" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NoncashInvestingAndFinancingItemsAbstract_881" xlink:to="Locator_us-gaap_TransferOfPortfolioLoansAndLeasesToHeldForSale1_882" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NoncashInvestingAndFinancingItemsAbstract" xlink:label="Locator_us-gaap_NoncashInvestingAndFinancingItemsAbstract_883" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_TransferOfSecuritiesAvailableForSaleToSecuritiesHeldForSale" xlink:label="Locator_uscb_TransferOfSecuritiesAvailableForSaleToSecuritiesHeldForSale_884" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NoncashInvestingAndFinancingItemsAbstract_883" xlink:to="Locator_uscb_TransferOfSecuritiesAvailableForSaleToSecuritiesHeldForSale_884" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NoncashInvestingAndFinancingItemsAbstract" xlink:label="Locator_us-gaap_NoncashInvestingAndFinancingItemsAbstract_885" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_TransferOfPropertyAndEquipmentToAssetsHeldForSale" xlink:label="Locator_uscb_TransferOfPropertyAndEquipmentToAssetsHeldForSale_886" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NoncashInvestingAndFinancingItemsAbstract_885" xlink:to="Locator_uscb_TransferOfPropertyAndEquipmentToAssetsHeldForSale_886" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NoncashInvestingAndFinancingItemsAbstract" xlink:label="Locator_us-gaap_NoncashInvestingAndFinancingItemsAbstract_887" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability" xlink:label="Locator_us-gaap_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability_888" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NoncashInvestingAndFinancingItemsAbstract_887" xlink:to="Locator_us-gaap_RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability_888" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NoncashInvestingAndFinancingItemsAbstract" xlink:label="Locator_us-gaap_NoncashInvestingAndFinancingItemsAbstract_889" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConversionOfStockAmountConverted1" xlink:label="Locator_us-gaap_ConversionOfStockAmountConverted1_890" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NoncashInvestingAndFinancingItemsAbstract_889" xlink:to="Locator_us-gaap_ConversionOfStockAmountConverted1_890" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_607" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable" xlink:label="Locator_us-gaap_StatementTable_608" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_us-gaap_StatementLineItems_607" xlink:to="Locator_us-gaap_StatementTable_608" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/ConsolidatedStatementsOfChangesInShareholdersEquity">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable" xlink:label="Locator_us-gaap_StatementTable_949" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CumulativeEffectPeriodOfAdoptionAxis" xlink:label="Locator_srt_CumulativeEffectPeriodOfAdoptionAxis_950" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_StatementTable_949" xlink:to="Locator_srt_CumulativeEffectPeriodOfAdoptionAxis_950" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CumulativeEffectPeriodOfAdoptionAxis" xlink:label="Locator_srt_CumulativeEffectPeriodOfAdoptionAxis_953" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CumulativeEffectPeriodOfAdoptionDomain" xlink:label="Locator_srt_CumulativeEffectPeriodOfAdoptionDomain_954" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_srt_CumulativeEffectPeriodOfAdoptionAxis_953" xlink:to="Locator_srt_CumulativeEffectPeriodOfAdoptionDomain_954" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CumulativeEffectPeriodOfAdoptionAxis" xlink:label="Locator_srt_CumulativeEffectPeriodOfAdoptionAxis_1007" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CumulativeEffectPeriodOfAdoptionDomain" xlink:label="Locator_srt_CumulativeEffectPeriodOfAdoptionDomain_1008" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_srt_CumulativeEffectPeriodOfAdoptionAxis_1007" xlink:to="Locator_srt_CumulativeEffectPeriodOfAdoptionDomain_1008" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CumulativeEffectPeriodOfAdoptionDomain" xlink:label="Locator_srt_CumulativeEffectPeriodOfAdoptionDomain_955" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember" xlink:label="Locator_srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember_956" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_srt_CumulativeEffectPeriodOfAdoptionDomain_955" xlink:to="Locator_srt_CumulativeEffectPeriodOfAdoptionAdjustmentMember_956" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CumulativeEffectPeriodOfAdoptionDomain" xlink:label="Locator_srt_CumulativeEffectPeriodOfAdoptionDomain_957" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CumulativeEffectPeriodOfAdoptionAdjustedBalanceMember" xlink:label="Locator_srt_CumulativeEffectPeriodOfAdoptionAdjustedBalanceMember_958" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_srt_CumulativeEffectPeriodOfAdoptionDomain_957" xlink:to="Locator_srt_CumulativeEffectPeriodOfAdoptionAdjustedBalanceMember_958" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable" xlink:label="Locator_us-gaap_StatementTable_951" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="Locator_us-gaap_StatementEquityComponentsAxis_952" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_StatementTable_951" xlink:to="Locator_us-gaap_StatementEquityComponentsAxis_952" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="Locator_us-gaap_StatementEquityComponentsAxis_959" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain" xlink:label="Locator_us-gaap_EquityComponentDomain_960" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_StatementEquityComponentsAxis_959" xlink:to="Locator_us-gaap_EquityComponentDomain_960" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="Locator_us-gaap_StatementEquityComponentsAxis_1009" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain" xlink:label="Locator_us-gaap_EquityComponentDomain_1010" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_us-gaap_StatementEquityComponentsAxis_1009" xlink:to="Locator_us-gaap_EquityComponentDomain_1010" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain" xlink:label="Locator_us-gaap_EquityComponentDomain_961" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockMember" xlink:label="Locator_us-gaap_PreferredStockMember_962" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_EquityComponentDomain_961" xlink:to="Locator_us-gaap_PreferredStockMember_962" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain" xlink:label="Locator_us-gaap_EquityComponentDomain_963" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockMember" xlink:label="Locator_us-gaap_CommonStockMember_964" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_EquityComponentDomain_963" xlink:to="Locator_us-gaap_CommonStockMember_964" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain" xlink:label="Locator_us-gaap_EquityComponentDomain_965" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdditionalPaidInCapitalMember" xlink:label="Locator_us-gaap_AdditionalPaidInCapitalMember_966" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_EquityComponentDomain_965" xlink:to="Locator_us-gaap_AdditionalPaidInCapitalMember_966" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain" xlink:label="Locator_us-gaap_EquityComponentDomain_967" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsMember" xlink:label="Locator_us-gaap_RetainedEarningsMember_968" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_EquityComponentDomain_967" xlink:to="Locator_us-gaap_RetainedEarningsMember_968" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain" xlink:label="Locator_us-gaap_EquityComponentDomain_969" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember" xlink:label="Locator_us-gaap_AccumulatedOtherComprehensiveIncomeMember_970" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_EquityComponentDomain_969" xlink:to="Locator_us-gaap_AccumulatedOtherComprehensiveIncomeMember_970" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_971" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity" xlink:label="Locator_us-gaap_StockholdersEquity_972" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_971" xlink:to="Locator_us-gaap_StockholdersEquity_972" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_973" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharesOutstanding" xlink:label="Locator_us-gaap_SharesOutstanding_974" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_973" xlink:to="Locator_us-gaap_SharesOutstanding_974" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_975" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesReverseStockSplits" xlink:label="Locator_us-gaap_StockIssuedDuringPeriodSharesReverseStockSplits_976" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_975" xlink:to="Locator_us-gaap_StockIssuedDuringPeriodSharesReverseStockSplits_976" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_977" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_StockIssuedDuringPeriodValueReverseStockSplits" xlink:label="Locator_uscb_StockIssuedDuringPeriodValueReverseStockSplits_978" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_977" xlink:to="Locator_uscb_StockIssuedDuringPeriodValueReverseStockSplits_978" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_979" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss" xlink:label="Locator_us-gaap_NetIncomeLoss_980" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_979" xlink:to="Locator_us-gaap_NetIncomeLoss_980" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_981" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent" xlink:label="Locator_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_982" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_981" xlink:to="Locator_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_982" order="6.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_983" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DividendsPreferredStock" xlink:label="Locator_us-gaap_DividendsPreferredStock_984" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_983" xlink:to="Locator_us-gaap_DividendsPreferredStock_984" order="7.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_985" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised" xlink:label="Locator_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_986" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_985" xlink:to="Locator_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_986" order="8.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_987" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised" xlink:label="Locator_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_988" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_987" xlink:to="Locator_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_988" order="9.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_989" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodValueNewIssues" xlink:label="Locator_us-gaap_StockIssuedDuringPeriodValueNewIssues_990" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_989" xlink:to="Locator_us-gaap_StockIssuedDuringPeriodValueNewIssues_990" order="10.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_991" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues" xlink:label="Locator_us-gaap_StockIssuedDuringPeriodSharesNewIssues_992" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_991" xlink:to="Locator_us-gaap_StockIssuedDuringPeriodSharesNewIssues_992" order="11.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_993" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities" xlink:label="Locator_us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities_994" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_993" xlink:to="Locator_us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities_994" order="12.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_995" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities" xlink:label="Locator_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_996" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_995" xlink:to="Locator_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_996" order="13.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_997" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockRedeemedOrCalledDuringPeriodValue" xlink:label="Locator_us-gaap_StockRedeemedOrCalledDuringPeriodValue_998" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_997" xlink:to="Locator_us-gaap_StockRedeemedOrCalledDuringPeriodValue_998" order="14.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_999" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockRedeemedOrCalledDuringPeriodShares" xlink:label="Locator_us-gaap_StockRedeemedOrCalledDuringPeriodShares_1000" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_999" xlink:to="Locator_us-gaap_StockRedeemedOrCalledDuringPeriodShares_1000" order="15.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_1001" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_StockIssuedDuringPeriodValueExchangeOfCommonStock" xlink:label="Locator_uscb_StockIssuedDuringPeriodValueExchangeOfCommonStock_1002" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_1001" xlink:to="Locator_uscb_StockIssuedDuringPeriodValueExchangeOfCommonStock_1002" order="16.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_1003" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_StockIssuedDuringPeriodSharesExchangeOfCommonStock" xlink:label="Locator_uscb_StockIssuedDuringPeriodSharesExchangeOfCommonStock_1004" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_1003" xlink:to="Locator_uscb_StockIssuedDuringPeriodSharesExchangeOfCommonStock_1004" order="17.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_1005" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue" xlink:label="Locator_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_1006" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_1005" xlink:to="Locator_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_1006" order="18.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_945" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable" xlink:label="Locator_us-gaap_StatementTable_946" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_us-gaap_StatementLineItems_945" xlink:to="Locator_us-gaap_StatementTable_946" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/ConsolidatedStatementsOfChangesInShareholdersEquityParenthetical">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable" xlink:label="Locator_us-gaap_StatementTable_1041" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="Locator_us-gaap_StatementClassOfStockAxis_1042" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_StatementTable_1041" xlink:to="Locator_us-gaap_StatementClassOfStockAxis_1042" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="Locator_us-gaap_StatementClassOfStockAxis_1043" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_1044" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_StatementClassOfStockAxis_1043" xlink:to="Locator_us-gaap_ClassOfStockDomain_1044" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_1045" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassAMember" xlink:label="Locator_us-gaap_CommonClassAMember_1046" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockDomain_1045" xlink:to="Locator_us-gaap_CommonClassAMember_1046" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_1037" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable" xlink:label="Locator_us-gaap_StatementTable_1038" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_us-gaap_StatementLineItems_1037" xlink:to="Locator_us-gaap_StatementTable_1038" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems" xlink:label="Locator_us-gaap_StatementLineItems_1047" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalStockIssuedIssuanceCosts" xlink:label="Locator_us-gaap_AdjustmentsToAdditionalPaidInCapitalStockIssuedIssuanceCosts_1048" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_StatementLineItems_1047" xlink:to="Locator_us-gaap_AdjustmentsToAdditionalPaidInCapitalStockIssuedIssuanceCosts_1048" order="1.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/IncomeTaxesNarrativeDetails">
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_IncomeTaxDisclosureLineItems" xlink:label="Locator_uscb_IncomeTaxDisclosureLineItems_1099" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_IncomeTaxDisclosureTable" xlink:label="Locator_uscb_IncomeTaxDisclosureTable_1100" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_uscb_IncomeTaxDisclosureLineItems_1099" xlink:to="Locator_uscb_IncomeTaxDisclosureTable_1100" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_IncomeTaxDisclosureTable" xlink:label="Locator_uscb_IncomeTaxDisclosureTable_1101" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxAuthorityAxis" xlink:label="Locator_us-gaap_IncomeTaxAuthorityAxis_1102" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_uscb_IncomeTaxDisclosureTable_1101" xlink:to="Locator_us-gaap_IncomeTaxAuthorityAxis_1102" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxAuthorityAxis" xlink:label="Locator_us-gaap_IncomeTaxAuthorityAxis_1103" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxAuthorityDomain" xlink:label="Locator_us-gaap_IncomeTaxAuthorityDomain_1104" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_IncomeTaxAuthorityAxis_1103" xlink:to="Locator_us-gaap_IncomeTaxAuthorityDomain_1104" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxAuthorityAxis" xlink:label="Locator_us-gaap_IncomeTaxAuthorityAxis_1105" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxAuthorityDomain" xlink:label="Locator_us-gaap_IncomeTaxAuthorityDomain_1106" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_us-gaap_IncomeTaxAuthorityAxis_1105" xlink:to="Locator_us-gaap_IncomeTaxAuthorityDomain_1106" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxAuthorityDomain" xlink:label="Locator_us-gaap_IncomeTaxAuthorityDomain_1107" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DomesticCountryMember" xlink:label="Locator_us-gaap_DomesticCountryMember_1108" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_IncomeTaxAuthorityDomain_1107" xlink:to="Locator_us-gaap_DomesticCountryMember_1108" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxAuthorityDomain" xlink:label="Locator_us-gaap_IncomeTaxAuthorityDomain_1109" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StateAndLocalJurisdictionMember" xlink:label="Locator_us-gaap_StateAndLocalJurisdictionMember_1110" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_IncomeTaxAuthorityDomain_1109" xlink:to="Locator_us-gaap_StateAndLocalJurisdictionMember_1110" order="2.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_IncomeTaxDisclosureLineItems" xlink:label="Locator_uscb_IncomeTaxDisclosureLineItems_1111" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate" xlink:label="Locator_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_1112" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_IncomeTaxDisclosureLineItems_1111" xlink:to="Locator_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_1112" order="1.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_IncomeTaxDisclosureLineItems" xlink:label="Locator_uscb_IncomeTaxDisclosureLineItems_1113" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLossCarryforwards" xlink:label="Locator_us-gaap_OperatingLossCarryforwards_1114" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_IncomeTaxDisclosureLineItems_1113" xlink:to="Locator_us-gaap_OperatingLossCarryforwards_1114" order="2.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_IncomeTaxDisclosureLineItems" xlink:label="Locator_uscb_IncomeTaxDisclosureLineItems_1115" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UnrecognizedTaxBenefits" xlink:label="Locator_us-gaap_UnrecognizedTaxBenefits_1116" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_IncomeTaxDisclosureLineItems_1115" xlink:to="Locator_us-gaap_UnrecognizedTaxBenefits_1116" order="3.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_IncomeTaxDisclosureLineItems" xlink:label="Locator_uscb_IncomeTaxDisclosureLineItems_1117" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestExpense" xlink:label="Locator_us-gaap_UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestExpense_1118" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_IncomeTaxDisclosureLineItems_1117" xlink:to="Locator_us-gaap_UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestExpense_1118" order="4.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/RegulatoryMattersScheduleOfActualCapitalAmountsAndRatiosDetails">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesAxis" xlink:label="Locator_srt_ConsolidatedEntitiesAxis_1203" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesDomain" xlink:label="Locator_srt_ConsolidatedEntitiesDomain_1204" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_srt_ConsolidatedEntitiesAxis_1203" xlink:to="Locator_srt_ConsolidatedEntitiesDomain_1204" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesDomain" xlink:label="Locator_srt_ConsolidatedEntitiesDomain_1207" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SubsidiariesMember" xlink:label="Locator_srt_SubsidiariesMember_1208" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_srt_ConsolidatedEntitiesDomain_1207" xlink:to="Locator_srt_SubsidiariesMember_1208" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesDomain" xlink:label="Locator_srt_ConsolidatedEntitiesDomain_1205" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ParentCompanyMember" xlink:label="Locator_srt_ParentCompanyMember_1206" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_srt_ConsolidatedEntitiesDomain_1205" xlink:to="Locator_srt_ParentCompanyMember_1206" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems" xlink:label="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1209" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Capital" xlink:label="Locator_us-gaap_Capital_1210" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1209" xlink:to="Locator_us-gaap_Capital_1210" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems" xlink:label="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1211" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CapitalToRiskWeightedAssets" xlink:label="Locator_us-gaap_CapitalToRiskWeightedAssets_1212" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1211" xlink:to="Locator_us-gaap_CapitalToRiskWeightedAssets_1212" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems" xlink:label="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1213" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CapitalRequiredForCapitalAdequacy" xlink:label="Locator_us-gaap_CapitalRequiredForCapitalAdequacy_1214" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1213" xlink:to="Locator_us-gaap_CapitalRequiredForCapitalAdequacy_1214" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems" xlink:label="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1215" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CapitalRequiredForCapitalAdequacyToRiskWeightedAssets" xlink:label="Locator_us-gaap_CapitalRequiredForCapitalAdequacyToRiskWeightedAssets_1216" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1215" xlink:to="Locator_us-gaap_CapitalRequiredForCapitalAdequacyToRiskWeightedAssets_1216" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems" xlink:label="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1217" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CapitalRequiredToBeWellCapitalized" xlink:label="Locator_us-gaap_CapitalRequiredToBeWellCapitalized_1218" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1217" xlink:to="Locator_us-gaap_CapitalRequiredToBeWellCapitalized_1218" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems" xlink:label="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1219" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CapitalRequiredToBeWellCapitalizedToRiskWeightedAssets" xlink:label="Locator_us-gaap_CapitalRequiredToBeWellCapitalizedToRiskWeightedAssets_1220" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1219" xlink:to="Locator_us-gaap_CapitalRequiredToBeWellCapitalizedToRiskWeightedAssets_1220" order="6.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems" xlink:label="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1221" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TierOneRiskBasedCapital" xlink:label="Locator_us-gaap_TierOneRiskBasedCapital_1222" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1221" xlink:to="Locator_us-gaap_TierOneRiskBasedCapital_1222" order="7.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems" xlink:label="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1223" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TierOneRiskBasedCapitalToRiskWeightedAssets" xlink:label="Locator_us-gaap_TierOneRiskBasedCapitalToRiskWeightedAssets_1224" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1223" xlink:to="Locator_us-gaap_TierOneRiskBasedCapitalToRiskWeightedAssets_1224" order="8.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems" xlink:label="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1225" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TierOneRiskBasedCapitalRequiredForCapitalAdequacy" xlink:label="Locator_us-gaap_TierOneRiskBasedCapitalRequiredForCapitalAdequacy_1226" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1225" xlink:to="Locator_us-gaap_TierOneRiskBasedCapitalRequiredForCapitalAdequacy_1226" order="9.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems" xlink:label="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1227" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TierOneRiskBasedCapitalRequiredForCapitalAdequacyToRiskWeightedAssets" xlink:label="Locator_us-gaap_TierOneRiskBasedCapitalRequiredForCapitalAdequacyToRiskWeightedAssets_1228" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1227" xlink:to="Locator_us-gaap_TierOneRiskBasedCapitalRequiredForCapitalAdequacyToRiskWeightedAssets_1228" order="10.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems" xlink:label="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1229" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TierOneRiskBasedCapitalRequiredToBeWellCapitalized" xlink:label="Locator_us-gaap_TierOneRiskBasedCapitalRequiredToBeWellCapitalized_1230" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1229" xlink:to="Locator_us-gaap_TierOneRiskBasedCapitalRequiredToBeWellCapitalized_1230" order="11.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems" xlink:label="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1231" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TierOneRiskBasedCapitalRequiredToBeWellCapitalizedToRiskWeightedAssets" xlink:label="Locator_us-gaap_TierOneRiskBasedCapitalRequiredToBeWellCapitalizedToRiskWeightedAssets_1232" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1231" xlink:to="Locator_us-gaap_TierOneRiskBasedCapitalRequiredToBeWellCapitalizedToRiskWeightedAssets_1232" order="12.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems" xlink:label="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1233" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_TierOneCommonEquity" xlink:label="Locator_uscb_TierOneCommonEquity_1234" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1233" xlink:to="Locator_uscb_TierOneCommonEquity_1234" order="13.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems" xlink:label="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1235" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_ExcessTierOneCommonEquityToRiskWeightedAssets" xlink:label="Locator_uscb_ExcessTierOneCommonEquityToRiskWeightedAssets_1236" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1235" xlink:to="Locator_uscb_ExcessTierOneCommonEquityToRiskWeightedAssets_1236" order="14.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems" xlink:label="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1237" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_TierOneCommonEquityRequiredForCapitalAdequacy" xlink:label="Locator_uscb_TierOneCommonEquityRequiredForCapitalAdequacy_1238" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1237" xlink:to="Locator_uscb_TierOneCommonEquityRequiredForCapitalAdequacy_1238" order="15.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems" xlink:label="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1239" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_TierOneCommonEquityRequiredForCapitalAdequacyToRiskWeightedAssets" xlink:label="Locator_uscb_TierOneCommonEquityRequiredForCapitalAdequacyToRiskWeightedAssets_1240" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1239" xlink:to="Locator_uscb_TierOneCommonEquityRequiredForCapitalAdequacyToRiskWeightedAssets_1240" order="16.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems" xlink:label="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1241" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_TierOneCommonEquityRequiredToBeWellCapitalized" xlink:label="Locator_uscb_TierOneCommonEquityRequiredToBeWellCapitalized_1242" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1241" xlink:to="Locator_uscb_TierOneCommonEquityRequiredToBeWellCapitalized_1242" order="17.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems" xlink:label="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1243" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_TierOneCommonEquityRequiredToBeWellCapitalizedToRiskWeightedAssets" xlink:label="Locator_uscb_TierOneCommonEquityRequiredToBeWellCapitalizedToRiskWeightedAssets_1244" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1243" xlink:to="Locator_uscb_TierOneCommonEquityRequiredToBeWellCapitalizedToRiskWeightedAssets_1244" order="18.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems" xlink:label="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1245" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TierOneLeverageCapital" xlink:label="Locator_us-gaap_TierOneLeverageCapital_1246" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1245" xlink:to="Locator_us-gaap_TierOneLeverageCapital_1246" order="19.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems" xlink:label="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1247" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TierOneLeverageCapitalToAverageAssets" xlink:label="Locator_us-gaap_TierOneLeverageCapitalToAverageAssets_1248" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1247" xlink:to="Locator_us-gaap_TierOneLeverageCapitalToAverageAssets_1248" order="20.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems" xlink:label="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1249" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TierOneLeverageCapitalRequiredForCapitalAdequacy" xlink:label="Locator_us-gaap_TierOneLeverageCapitalRequiredForCapitalAdequacy_1250" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1249" xlink:to="Locator_us-gaap_TierOneLeverageCapitalRequiredForCapitalAdequacy_1250" order="21.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems" xlink:label="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1251" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TierOneLeverageCapitalRequiredForCapitalAdequacyToAverageAssets" xlink:label="Locator_us-gaap_TierOneLeverageCapitalRequiredForCapitalAdequacyToAverageAssets_1252" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1251" xlink:to="Locator_us-gaap_TierOneLeverageCapitalRequiredForCapitalAdequacyToAverageAssets_1252" order="22.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems" xlink:label="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1253" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TierOneLeverageCapitalRequiredToBeWellCapitalized" xlink:label="Locator_us-gaap_TierOneLeverageCapitalRequiredToBeWellCapitalized_1254" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1253" xlink:to="Locator_us-gaap_TierOneLeverageCapitalRequiredToBeWellCapitalized_1254" order="23.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems" xlink:label="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1255" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TierOneLeverageCapitalRequiredToBeWellCapitalizedToAverageAssets" xlink:label="Locator_us-gaap_TierOneLeverageCapitalRequiredToBeWellCapitalizedToAverageAssets_1256" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1255" xlink:to="Locator_us-gaap_TierOneLeverageCapitalRequiredToBeWellCapitalizedToAverageAssets_1256" order="24.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems" xlink:label="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1199" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsTable" xlink:label="Locator_us-gaap_ScheduleOfComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsTable_1200" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_1199" xlink:to="Locator_us-gaap_ScheduleOfComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsTable_1200" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsTable" xlink:label="Locator_us-gaap_ScheduleOfComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsTable_1201" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesAxis" xlink:label="Locator_srt_ConsolidatedEntitiesAxis_1202" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_ScheduleOfComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsTable_1201" xlink:to="Locator_srt_ConsolidatedEntitiesAxis_1202" order="1.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/SummaryOfSignificantAccountingPoliciesNarrativeDetails">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain" xlink:label="Locator_srt_SegmentGeographicalDomain_1337" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_EcuadorHondurasPanamaAndElSalvadorMember" xlink:label="Locator_uscb_EcuadorHondurasPanamaAndElSalvadorMember_1338" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_srt_SegmentGeographicalDomain_1337" xlink:to="Locator_uscb_EcuadorHondurasPanamaAndElSalvadorMember_1338" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain" xlink:label="Locator_srt_SegmentGeographicalDomain_1339" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_EcuadorAndHondurasMember" xlink:label="Locator_uscb_EcuadorAndHondurasMember_1340" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_srt_SegmentGeographicalDomain_1339" xlink:to="Locator_uscb_EcuadorAndHondurasMember_1340" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1391" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_UnfundedCommitmentsMember" xlink:label="Locator_uscb_UnfundedCommitmentsMember_1392" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1391" xlink:to="Locator_uscb_UnfundedCommitmentsMember_1392" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1393" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommercialMortgageBackedSecuritiesMember" xlink:label="Locator_us-gaap_CommercialMortgageBackedSecuritiesMember_1394" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1393" xlink:to="Locator_us-gaap_CommercialMortgageBackedSecuritiesMember_1394" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PledgedStatusDomain" xlink:label="Locator_us-gaap_PledgedStatusDomain_1397" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetPledgedAsCollateralWithoutRightMember" xlink:label="Locator_us-gaap_AssetPledgedAsCollateralWithoutRightMember_1398" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_PledgedStatusDomain_1397" xlink:to="Locator_us-gaap_AssetPledgedAsCollateralWithoutRightMember_1398" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain" xlink:label="Locator_srt_ProductsAndServicesDomain_1341" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_TopTenLendingRelationshipsMember" xlink:label="Locator_uscb_TopTenLendingRelationshipsMember_1342" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_srt_ProductsAndServicesDomain_1341" xlink:to="Locator_uscb_TopTenLendingRelationshipsMember_1342" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis" xlink:label="Locator_us-gaap_ConcentrationRiskByBenchmarkAxis_1343" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskBenchmarkDomain" xlink:label="Locator_us-gaap_ConcentrationRiskBenchmarkDomain_1344" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_ConcentrationRiskByBenchmarkAxis_1343" xlink:to="Locator_us-gaap_ConcentrationRiskBenchmarkDomain_1344" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis" xlink:label="Locator_us-gaap_ConcentrationRiskByBenchmarkAxis_1447" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskBenchmarkDomain" xlink:label="Locator_us-gaap_ConcentrationRiskBenchmarkDomain_1448" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_us-gaap_ConcentrationRiskByBenchmarkAxis_1447" xlink:to="Locator_us-gaap_ConcentrationRiskBenchmarkDomain_1448" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskBenchmarkDomain" xlink:label="Locator_us-gaap_ConcentrationRiskBenchmarkDomain_1347" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_LoansOutstandingMember" xlink:label="Locator_uscb_LoansOutstandingMember_1348" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ConcentrationRiskBenchmarkDomain_1347" xlink:to="Locator_uscb_LoansOutstandingMember_1348" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskBenchmarkDomain" xlink:label="Locator_us-gaap_ConcentrationRiskBenchmarkDomain_1345" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsReceivableMember" xlink:label="Locator_us-gaap_AccountsReceivableMember_1346" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ConcentrationRiskBenchmarkDomain_1345" xlink:to="Locator_us-gaap_AccountsReceivableMember_1346" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskByTypeAxis" xlink:label="Locator_us-gaap_ConcentrationRiskByTypeAxis_1349" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskTypeDomain" xlink:label="Locator_us-gaap_ConcentrationRiskTypeDomain_1350" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_ConcentrationRiskByTypeAxis_1349" xlink:to="Locator_us-gaap_ConcentrationRiskTypeDomain_1350" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskByTypeAxis" xlink:label="Locator_us-gaap_ConcentrationRiskByTypeAxis_1445" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskTypeDomain" xlink:label="Locator_us-gaap_ConcentrationRiskTypeDomain_1446" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_us-gaap_ConcentrationRiskByTypeAxis_1445" xlink:to="Locator_us-gaap_ConcentrationRiskTypeDomain_1446" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskTypeDomain" xlink:label="Locator_us-gaap_ConcentrationRiskTypeDomain_1351" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CustomerConcentrationRiskMember" xlink:label="Locator_us-gaap_CustomerConcentrationRiskMember_1352" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ConcentrationRiskTypeDomain_1351" xlink:to="Locator_us-gaap_CustomerConcentrationRiskMember_1352" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="Locator_us-gaap_StatementClassOfStockAxis_1381" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_1382" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_StatementClassOfStockAxis_1381" xlink:to="Locator_us-gaap_ClassOfStockDomain_1382" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_1383" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassAMember" xlink:label="Locator_us-gaap_CommonClassAMember_1384" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockDomain_1383" xlink:to="Locator_us-gaap_CommonClassAMember_1384" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesAxis" xlink:label="Locator_srt_ConsolidatedEntitiesAxis_1353" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesDomain" xlink:label="Locator_srt_ConsolidatedEntitiesDomain_1354" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_srt_ConsolidatedEntitiesAxis_1353" xlink:to="Locator_srt_ConsolidatedEntitiesDomain_1354" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesDomain" xlink:label="Locator_srt_ConsolidatedEntitiesDomain_1355" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SubsidiariesMember" xlink:label="Locator_srt_SubsidiariesMember_1356" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_srt_ConsolidatedEntitiesDomain_1355" xlink:to="Locator_srt_SubsidiariesMember_1356" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="Locator_us-gaap_FinancialInstrumentAxis_1389" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1390" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_FinancialInstrumentAxis_1389" xlink:to="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1390" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:label="Locator_us-gaap_PropertyPlantAndEquipmentByTypeAxis_1357" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="Locator_us-gaap_PropertyPlantAndEquipmentTypeDomain_1358" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_PropertyPlantAndEquipmentByTypeAxis_1357" xlink:to="Locator_us-gaap_PropertyPlantAndEquipmentTypeDomain_1358" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="Locator_us-gaap_PropertyPlantAndEquipmentTypeDomain_1359" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BuildingMember" xlink:label="Locator_us-gaap_BuildingMember_1360" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_PropertyPlantAndEquipmentTypeDomain_1359" xlink:to="Locator_us-gaap_BuildingMember_1360" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="Locator_us-gaap_PropertyPlantAndEquipmentTypeDomain_1361" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FurnitureAndFixturesMember" xlink:label="Locator_us-gaap_FurnitureAndFixturesMember_1362" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_PropertyPlantAndEquipmentTypeDomain_1361" xlink:to="Locator_us-gaap_FurnitureAndFixturesMember_1362" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="Locator_us-gaap_PropertyPlantAndEquipmentTypeDomain_1363" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComputerEquipmentMember" xlink:label="Locator_us-gaap_ComputerEquipmentMember_1364" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_PropertyPlantAndEquipmentTypeDomain_1363" xlink:to="Locator_us-gaap_ComputerEquipmentMember_1364" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="Locator_us-gaap_PropertyPlantAndEquipmentTypeDomain_1365" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeaseholdImprovementsMember" xlink:label="Locator_us-gaap_LeaseholdImprovementsMember_1366" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_PropertyPlantAndEquipmentTypeDomain_1365" xlink:to="Locator_us-gaap_LeaseholdImprovementsMember_1366" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameAxis" xlink:label="Locator_us-gaap_PlanNameAxis_1367" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameDomain" xlink:label="Locator_us-gaap_PlanNameDomain_1368" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_PlanNameAxis_1367" xlink:to="Locator_us-gaap_PlanNameDomain_1368" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameDomain" xlink:label="Locator_us-gaap_PlanNameDomain_1369" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_EquityIncentive2015PlanMember" xlink:label="Locator_uscb_EquityIncentive2015PlanMember_1370" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_PlanNameDomain_1369" xlink:to="Locator_uscb_EquityIncentive2015PlanMember_1370" order="1.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_SignificantAccountingPoliciesDisclosureLineItems" xlink:label="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1309" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_SignificantAccountingPoliciesDisclosureTable" xlink:label="Locator_uscb_SignificantAccountingPoliciesDisclosureTable_1310" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1309" xlink:to="Locator_uscb_SignificantAccountingPoliciesDisclosureTable_1310" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_SignificantAccountingPoliciesDisclosureTable" xlink:label="Locator_uscb_SignificantAccountingPoliciesDisclosureTable_1313" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis" xlink:label="Locator_us-gaap_ConcentrationRiskByBenchmarkAxis_1314" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_uscb_SignificantAccountingPoliciesDisclosureTable_1313" xlink:to="Locator_us-gaap_ConcentrationRiskByBenchmarkAxis_1314" order="1.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_SignificantAccountingPoliciesDisclosureTable" xlink:label="Locator_uscb_SignificantAccountingPoliciesDisclosureTable_1315" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskByTypeAxis" xlink:label="Locator_us-gaap_ConcentrationRiskByTypeAxis_1316" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_uscb_SignificantAccountingPoliciesDisclosureTable_1315" xlink:to="Locator_us-gaap_ConcentrationRiskByTypeAxis_1316" order="2.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_SignificantAccountingPoliciesDisclosureTable" xlink:label="Locator_uscb_SignificantAccountingPoliciesDisclosureTable_1317" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_StatementGeographicalAxis" xlink:label="Locator_srt_StatementGeographicalAxis_1318" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_uscb_SignificantAccountingPoliciesDisclosureTable_1317" xlink:to="Locator_srt_StatementGeographicalAxis_1318" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_StatementGeographicalAxis" xlink:label="Locator_srt_StatementGeographicalAxis_1371" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain" xlink:label="Locator_srt_SegmentGeographicalDomain_1372" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_srt_StatementGeographicalAxis_1371" xlink:to="Locator_srt_SegmentGeographicalDomain_1372" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_StatementGeographicalAxis" xlink:label="Locator_srt_StatementGeographicalAxis_1443" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain" xlink:label="Locator_srt_SegmentGeographicalDomain_1444" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_srt_StatementGeographicalAxis_1443" xlink:to="Locator_srt_SegmentGeographicalDomain_1444" order="1.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_SignificantAccountingPoliciesDisclosureTable" xlink:label="Locator_uscb_SignificantAccountingPoliciesDisclosureTable_1319" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:label="Locator_us-gaap_PropertyPlantAndEquipmentByTypeAxis_1320" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_uscb_SignificantAccountingPoliciesDisclosureTable_1319" xlink:to="Locator_us-gaap_PropertyPlantAndEquipmentByTypeAxis_1320" order="4.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_SignificantAccountingPoliciesDisclosureTable" xlink:label="Locator_uscb_SignificantAccountingPoliciesDisclosureTable_1321" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis" xlink:label="Locator_srt_RangeAxis_1322" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_uscb_SignificantAccountingPoliciesDisclosureTable_1321" xlink:to="Locator_srt_RangeAxis_1322" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis" xlink:label="Locator_srt_RangeAxis_1373" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember" xlink:label="Locator_srt_RangeMember_1374" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_srt_RangeAxis_1373" xlink:to="Locator_srt_RangeMember_1374" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember" xlink:label="Locator_srt_RangeMember_1377" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MinimumMember" xlink:label="Locator_srt_MinimumMember_1378" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_srt_RangeMember_1377" xlink:to="Locator_srt_MinimumMember_1378" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember" xlink:label="Locator_srt_RangeMember_1375" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember" xlink:label="Locator_srt_MaximumMember_1376" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_srt_RangeMember_1375" xlink:to="Locator_srt_MaximumMember_1376" order="1.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_SignificantAccountingPoliciesDisclosureTable" xlink:label="Locator_uscb_SignificantAccountingPoliciesDisclosureTable_1323" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesAxis" xlink:label="Locator_srt_ConsolidatedEntitiesAxis_1324" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_uscb_SignificantAccountingPoliciesDisclosureTable_1323" xlink:to="Locator_srt_ConsolidatedEntitiesAxis_1324" order="6.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_SignificantAccountingPoliciesDisclosureTable" xlink:label="Locator_uscb_SignificantAccountingPoliciesDisclosureTable_1325" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameAxis" xlink:label="Locator_us-gaap_PlanNameAxis_1326" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_uscb_SignificantAccountingPoliciesDisclosureTable_1325" xlink:to="Locator_us-gaap_PlanNameAxis_1326" order="7.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_SignificantAccountingPoliciesDisclosureTable" xlink:label="Locator_uscb_SignificantAccountingPoliciesDisclosureTable_1327" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductOrServiceAxis" xlink:label="Locator_srt_ProductOrServiceAxis_1328" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_uscb_SignificantAccountingPoliciesDisclosureTable_1327" xlink:to="Locator_srt_ProductOrServiceAxis_1328" order="8.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductOrServiceAxis" xlink:label="Locator_srt_ProductOrServiceAxis_1379" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain" xlink:label="Locator_srt_ProductsAndServicesDomain_1380" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_srt_ProductOrServiceAxis_1379" xlink:to="Locator_srt_ProductsAndServicesDomain_1380" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductOrServiceAxis" xlink:label="Locator_srt_ProductOrServiceAxis_1441" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain" xlink:label="Locator_srt_ProductsAndServicesDomain_1442" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_srt_ProductOrServiceAxis_1441" xlink:to="Locator_srt_ProductsAndServicesDomain_1442" order="1.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_SignificantAccountingPoliciesDisclosureTable" xlink:label="Locator_uscb_SignificantAccountingPoliciesDisclosureTable_1329" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="Locator_us-gaap_StatementClassOfStockAxis_1330" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_uscb_SignificantAccountingPoliciesDisclosureTable_1329" xlink:to="Locator_us-gaap_StatementClassOfStockAxis_1330" order="9.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_SignificantAccountingPoliciesDisclosureTable" xlink:label="Locator_uscb_SignificantAccountingPoliciesDisclosureTable_1331" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_StatementScenarioAxis" xlink:label="Locator_srt_StatementScenarioAxis_1332" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_uscb_SignificantAccountingPoliciesDisclosureTable_1331" xlink:to="Locator_srt_StatementScenarioAxis_1332" order="10.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_StatementScenarioAxis" xlink:label="Locator_srt_StatementScenarioAxis_1385" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ScenarioUnspecifiedDomain" xlink:label="Locator_srt_ScenarioUnspecifiedDomain_1386" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_srt_StatementScenarioAxis_1385" xlink:to="Locator_srt_ScenarioUnspecifiedDomain_1386" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ScenarioUnspecifiedDomain" xlink:label="Locator_srt_ScenarioUnspecifiedDomain_1387" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ScenarioForecastMember" xlink:label="Locator_srt_ScenarioForecastMember_1388" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_srt_ScenarioUnspecifiedDomain_1387" xlink:to="Locator_srt_ScenarioForecastMember_1388" order="1.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_SignificantAccountingPoliciesDisclosureTable" xlink:label="Locator_uscb_SignificantAccountingPoliciesDisclosureTable_1333" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="Locator_us-gaap_FinancialInstrumentAxis_1334" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_uscb_SignificantAccountingPoliciesDisclosureTable_1333" xlink:to="Locator_us-gaap_FinancialInstrumentAxis_1334" order="11.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_SignificantAccountingPoliciesDisclosureTable" xlink:label="Locator_uscb_SignificantAccountingPoliciesDisclosureTable_1335" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PledgedStatusAxis" xlink:label="Locator_us-gaap_PledgedStatusAxis_1336" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_uscb_SignificantAccountingPoliciesDisclosureTable_1335" xlink:to="Locator_us-gaap_PledgedStatusAxis_1336" order="12.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PledgedStatusAxis" xlink:label="Locator_us-gaap_PledgedStatusAxis_1395" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PledgedStatusDomain" xlink:label="Locator_us-gaap_PledgedStatusDomain_1396" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_PledgedStatusAxis_1395" xlink:to="Locator_us-gaap_PledgedStatusDomain_1396" order="1.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_SignificantAccountingPoliciesDisclosureLineItems" xlink:label="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1399" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_NumberOfTopLendingRelationships" xlink:label="Locator_uscb_NumberOfTopLendingRelationships_1400" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1399" xlink:to="Locator_uscb_NumberOfTopLendingRelationships_1400" order="1.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_SignificantAccountingPoliciesDisclosureLineItems" xlink:label="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1401" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LoansAndLeasesReceivableNetOfDeferredIncome" xlink:label="Locator_us-gaap_LoansAndLeasesReceivableNetOfDeferredIncome_1402" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1401" xlink:to="Locator_us-gaap_LoansAndLeasesReceivableNetOfDeferredIncome_1402" order="2.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_SignificantAccountingPoliciesDisclosureLineItems" xlink:label="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1403" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskPercentage1" xlink:label="Locator_us-gaap_ConcentrationRiskPercentage1_1404" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1403" xlink:to="Locator_us-gaap_ConcentrationRiskPercentage1_1404" order="3.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_SignificantAccountingPoliciesDisclosureLineItems" xlink:label="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1405" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_NumberOfLoansPledgedAsCollateral" xlink:label="Locator_uscb_NumberOfLoansPledgedAsCollateral_1406" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1405" xlink:to="Locator_uscb_NumberOfLoansPledgedAsCollateral_1406" order="4.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_SignificantAccountingPoliciesDisclosureLineItems" xlink:label="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1407" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NotesReceivableGross" xlink:label="Locator_us-gaap_NotesReceivableGross_1408" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1407" xlink:to="Locator_us-gaap_NotesReceivableGross_1408" order="5.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_SignificantAccountingPoliciesDisclosureLineItems" xlink:label="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1409" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EscrowDeposit" xlink:label="Locator_us-gaap_EscrowDeposit_1410" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1409" xlink:to="Locator_us-gaap_EscrowDeposit_1410" order="6.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_SignificantAccountingPoliciesDisclosureLineItems" xlink:label="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1411" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityNoteStockSplitConversionRatio1" xlink:label="Locator_us-gaap_StockholdersEquityNoteStockSplitConversionRatio1_1412" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1411" xlink:to="Locator_us-gaap_StockholdersEquityNoteStockSplitConversionRatio1_1412" order="7.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_SignificantAccountingPoliciesDisclosureLineItems" xlink:label="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1413" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FederalHomeLoanBankStock" xlink:label="Locator_us-gaap_FederalHomeLoanBankStock_1414" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1413" xlink:to="Locator_us-gaap_FederalHomeLoanBankStock_1414" order="8.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_SignificantAccountingPoliciesDisclosureLineItems" xlink:label="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1415" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BankOwnedLifeInsurance" xlink:label="Locator_us-gaap_BankOwnedLifeInsurance_1416" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1415" xlink:to="Locator_us-gaap_BankOwnedLifeInsurance_1416" order="9.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_SignificantAccountingPoliciesDisclosureLineItems" xlink:label="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1417" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentUsefulLife" xlink:label="Locator_us-gaap_PropertyPlantAndEquipmentUsefulLife_1418" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1417" xlink:to="Locator_us-gaap_PropertyPlantAndEquipmentUsefulLife_1418" order="10.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_SignificantAccountingPoliciesDisclosureLineItems" xlink:label="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1419" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockParOrStatedValuePerShare" xlink:label="Locator_us-gaap_CommonStockParOrStatedValuePerShare_1420" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1419" xlink:to="Locator_us-gaap_CommonStockParOrStatedValuePerShare_1420" order="11.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_SignificantAccountingPoliciesDisclosureLineItems" xlink:label="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1421" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod" xlink:label="Locator_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_1422" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1421" xlink:to="Locator_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_1422" order="12.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_SignificantAccountingPoliciesDisclosureLineItems" xlink:label="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1423" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized_1424" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1423" xlink:to="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized_1424" order="13.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_SignificantAccountingPoliciesDisclosureLineItems" xlink:label="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1425" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_ShareBasedCompensationArrangementByShareBasedPaymentAwardExtendedLifeOfOptionPlan" xlink:label="Locator_uscb_ShareBasedCompensationArrangementByShareBasedPaymentAwardExtendedLifeOfOptionPlan_1426" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1425" xlink:to="Locator_uscb_ShareBasedCompensationArrangementByShareBasedPaymentAwardExtendedLifeOfOptionPlan_1426" order="14.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_SignificantAccountingPoliciesDisclosureLineItems" xlink:label="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1427" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockSharesOutstanding" xlink:label="Locator_us-gaap_PreferredStockSharesOutstanding_1428" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1427" xlink:to="Locator_us-gaap_PreferredStockSharesOutstanding_1428" order="15.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_SignificantAccountingPoliciesDisclosureLineItems" xlink:label="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1429" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockSharesIssued" xlink:label="Locator_us-gaap_PreferredStockSharesIssued_1430" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1429" xlink:to="Locator_us-gaap_PreferredStockSharesIssued_1430" order="16.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_SignificantAccountingPoliciesDisclosureLineItems" xlink:label="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1431" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_1432" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1431" xlink:to="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_1432" order="17.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_SignificantAccountingPoliciesDisclosureLineItems" xlink:label="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1433" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableAllowanceForCreditLosses" xlink:label="Locator_us-gaap_FinancingReceivableAllowanceForCreditLosses_1434" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1433" xlink:to="Locator_us-gaap_FinancingReceivableAllowanceForCreditLosses_1434" order="18.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_SignificantAccountingPoliciesDisclosureLineItems" xlink:label="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1435" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableAllowanceForCreditLossesPeriodIncreaseDecrease" xlink:label="Locator_us-gaap_FinancingReceivableAllowanceForCreditLossesPeriodIncreaseDecrease_1436" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1435" xlink:to="Locator_us-gaap_FinancingReceivableAllowanceForCreditLossesPeriodIncreaseDecrease_1436" order="19.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_SignificantAccountingPoliciesDisclosureLineItems" xlink:label="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1437" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_FairValueDisclosureOffBalanceSheetRisksFaceAmountLiabilityIncrease" xlink:label="Locator_uscb_FairValueDisclosureOffBalanceSheetRisksFaceAmountLiabilityIncrease_1438" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1437" xlink:to="Locator_uscb_FairValueDisclosureOffBalanceSheetRisksFaceAmountLiabilityIncrease_1438" order="20.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_SignificantAccountingPoliciesDisclosureLineItems" xlink:label="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1439" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueDisclosureOffbalanceSheetRisksFaceAmountLiability" xlink:label="Locator_us-gaap_FairValueDisclosureOffbalanceSheetRisksFaceAmountLiability_1440" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_SignificantAccountingPoliciesDisclosureLineItems_1439" xlink:to="Locator_us-gaap_FairValueDisclosureOffbalanceSheetRisksFaceAmountLiability_1440" order="21.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/InvestmentSecuritiesScheduleOfAvailableforsaleSecuritiesAndHeldtomaturitySecuritiesReconciliationDetails">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1653" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember" xlink:label="Locator_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_1654" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1653" xlink:to="Locator_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_1654" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1655" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USTreasurySecuritiesMember" xlink:label="Locator_us-gaap_USTreasurySecuritiesMember_1656" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1655" xlink:to="Locator_us-gaap_USTreasurySecuritiesMember_1656" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1657" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CollateralizedMortgageObligationsMember" xlink:label="Locator_us-gaap_CollateralizedMortgageObligationsMember_1658" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1657" xlink:to="Locator_us-gaap_CollateralizedMortgageObligationsMember_1658" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1659" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResidentialMortgageBackedSecuritiesMember" xlink:label="Locator_us-gaap_ResidentialMortgageBackedSecuritiesMember_1660" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1659" xlink:to="Locator_us-gaap_ResidentialMortgageBackedSecuritiesMember_1660" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1661" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommercialMortgageBackedSecuritiesMember" xlink:label="Locator_us-gaap_CommercialMortgageBackedSecuritiesMember_1662" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1661" xlink:to="Locator_us-gaap_CommercialMortgageBackedSecuritiesMember_1662" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1663" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USStatesAndPoliticalSubdivisionsMember" xlink:label="Locator_us-gaap_USStatesAndPoliticalSubdivisionsMember_1664" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1663" xlink:to="Locator_us-gaap_USStatesAndPoliticalSubdivisionsMember_1664" order="6.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1665" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_BankSubordinatedDebtSecuritiesMember" xlink:label="Locator_uscb_BankSubordinatedDebtSecuritiesMember_1666" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1665" xlink:to="Locator_uscb_BankSubordinatedDebtSecuritiesMember_1666" order="7.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1667" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CorporateBondSecuritiesMember" xlink:label="Locator_us-gaap_CorporateBondSecuritiesMember_1668" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1667" xlink:to="Locator_us-gaap_CorporateBondSecuritiesMember_1668" order="8.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="Locator_us-gaap_FinancialInstrumentAxis_1669" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1670" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_FinancialInstrumentAxis_1669" xlink:to="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1670" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="Locator_us-gaap_FinancialInstrumentAxis_1691" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1692" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_us-gaap_FinancialInstrumentAxis_1691" xlink:to="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1692" order="1.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_1671" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesAbstract" xlink:label="Locator_us-gaap_AvailableForSaleSecuritiesAbstract_1672" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_1671" xlink:to="Locator_us-gaap_AvailableForSaleSecuritiesAbstract_1672" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesAbstract" xlink:label="Locator_us-gaap_AvailableForSaleSecuritiesAbstract_1673" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis" xlink:label="Locator_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_1674" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AvailableForSaleSecuritiesAbstract_1673" xlink:to="Locator_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_1674" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesAbstract" xlink:label="Locator_us-gaap_AvailableForSaleSecuritiesAbstract_1675" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" xlink:label="Locator_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_1676" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AvailableForSaleSecuritiesAbstract_1675" xlink:to="Locator_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_1676" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesAbstract" xlink:label="Locator_us-gaap_AvailableForSaleSecuritiesAbstract_1677" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" xlink:label="Locator_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_1678" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AvailableForSaleSecuritiesAbstract_1677" xlink:to="Locator_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_1678" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesAbstract" xlink:label="Locator_us-gaap_AvailableForSaleSecuritiesAbstract_1679" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:label="Locator_us-gaap_AvailableForSaleSecuritiesDebtSecurities_1680" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AvailableForSaleSecuritiesAbstract_1679" xlink:to="Locator_us-gaap_AvailableForSaleSecuritiesDebtSecurities_1680" order="4.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_1681" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecuritiesAbstract" xlink:label="Locator_us-gaap_HeldToMaturitySecuritiesAbstract_1682" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_1681" xlink:to="Locator_us-gaap_HeldToMaturitySecuritiesAbstract_1682" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecuritiesAbstract" xlink:label="Locator_us-gaap_HeldToMaturitySecuritiesAbstract_1683" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecurities" xlink:label="Locator_us-gaap_HeldToMaturitySecurities_1684" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_HeldToMaturitySecuritiesAbstract_1683" xlink:to="Locator_us-gaap_HeldToMaturitySecurities_1684" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecuritiesAbstract" xlink:label="Locator_us-gaap_HeldToMaturitySecuritiesAbstract_1685" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingGain" xlink:label="Locator_us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingGain_1686" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_HeldToMaturitySecuritiesAbstract_1685" xlink:to="Locator_us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingGain_1686" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecuritiesAbstract" xlink:label="Locator_us-gaap_HeldToMaturitySecuritiesAbstract_1687" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingLoss" xlink:label="Locator_us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingLoss_1688" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_HeldToMaturitySecuritiesAbstract_1687" xlink:to="Locator_us-gaap_HeldToMaturitySecuritiesAccumulatedUnrecognizedHoldingLoss_1688" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecuritiesAbstract" xlink:label="Locator_us-gaap_HeldToMaturitySecuritiesAbstract_1689" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecuritiesFairValue" xlink:label="Locator_us-gaap_HeldToMaturitySecuritiesFairValue_1690" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_HeldToMaturitySecuritiesAbstract_1689" xlink:to="Locator_us-gaap_HeldToMaturitySecuritiesFairValue_1690" order="4.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_1619" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable_1620" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_1619" xlink:to="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable_1620" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable_1651" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="Locator_us-gaap_FinancialInstrumentAxis_1652" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable_1651" xlink:to="Locator_us-gaap_FinancialInstrumentAxis_1652" order="1.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/InvestmentSecuritiesNarrativeDetails">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain" xlink:label="Locator_srt_SegmentGeographicalDomain_1753" />
        <loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/stpr/2022/stpr-2022.xsd#stpr_FL" xlink:label="Locator_stpr_FL_1754" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_srt_SegmentGeographicalDomain_1753" xlink:to="Locator_stpr_FL_1754" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1757" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_MortgageBackedSecuritiesAndCollateralizedMortageObligationsOfGovernmentSponsoredEntitiesMember" xlink:label="Locator_uscb_MortgageBackedSecuritiesAndCollateralizedMortageObligationsOfGovernmentSponsoredEntitiesMember_1758" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1757" xlink:to="Locator_uscb_MortgageBackedSecuritiesAndCollateralizedMortageObligationsOfGovernmentSponsoredEntitiesMember_1758" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1755" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CorporateBondSecuritiesMember" xlink:label="Locator_us-gaap_CorporateBondSecuritiesMember_1756" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1755" xlink:to="Locator_us-gaap_CorporateBondSecuritiesMember_1756" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PledgedStatusDomain" xlink:label="Locator_us-gaap_PledgedStatusDomain_1775" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetPledgedAsCollateralWithRightMember" xlink:label="Locator_us-gaap_AssetPledgedAsCollateralWithRightMember_1776" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_PledgedStatusDomain_1775" xlink:to="Locator_us-gaap_AssetPledgedAsCollateralWithRightMember_1776" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PledgingPurposeAxis" xlink:label="Locator_us-gaap_PledgingPurposeAxis_1777" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PledgingPurposeDomain" xlink:label="Locator_us-gaap_PledgingPurposeDomain_1778" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_PledgingPurposeAxis_1777" xlink:to="Locator_us-gaap_PledgingPurposeDomain_1778" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PledgingPurposeAxis" xlink:label="Locator_us-gaap_PledgingPurposeAxis_1803" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PledgingPurposeDomain" xlink:label="Locator_us-gaap_PledgingPurposeDomain_1804" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_us-gaap_PledgingPurposeAxis_1803" xlink:to="Locator_us-gaap_PledgingPurposeDomain_1804" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PledgingPurposeDomain" xlink:label="Locator_us-gaap_PledgingPurposeDomain_1779" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseMember" xlink:label="Locator_us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseMember_1780" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_PledgingPurposeDomain_1779" xlink:to="Locator_us-gaap_SecuritiesSoldUnderAgreementsToRepurchaseMember_1780" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="Locator_us-gaap_FinancialInstrumentAxis_1759" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1760" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_FinancialInstrumentAxis_1759" xlink:to="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1760" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_StatementGeographicalAxis" xlink:label="Locator_srt_StatementGeographicalAxis_1761" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain" xlink:label="Locator_srt_SegmentGeographicalDomain_1762" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_srt_StatementGeographicalAxis_1761" xlink:to="Locator_srt_SegmentGeographicalDomain_1762" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis" xlink:label="Locator_srt_RangeAxis_1763" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember" xlink:label="Locator_srt_RangeMember_1764" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_srt_RangeAxis_1763" xlink:to="Locator_srt_RangeMember_1764" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis" xlink:label="Locator_srt_RangeAxis_1809" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember" xlink:label="Locator_srt_RangeMember_1810" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_srt_RangeAxis_1809" xlink:to="Locator_srt_RangeMember_1810" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember" xlink:label="Locator_srt_RangeMember_1765" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MinimumMember" xlink:label="Locator_srt_MinimumMember_1766" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_srt_RangeMember_1765" xlink:to="Locator_srt_MinimumMember_1766" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember" xlink:label="Locator_srt_RangeMember_1767" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember" xlink:label="Locator_srt_MaximumMember_1768" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_srt_RangeMember_1767" xlink:to="Locator_srt_MaximumMember_1768" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_StatementScenarioAxis" xlink:label="Locator_srt_StatementScenarioAxis_1769" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ScenarioUnspecifiedDomain" xlink:label="Locator_srt_ScenarioUnspecifiedDomain_1770" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_srt_StatementScenarioAxis_1769" xlink:to="Locator_srt_ScenarioUnspecifiedDomain_1770" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_StatementScenarioAxis" xlink:label="Locator_srt_StatementScenarioAxis_1807" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ScenarioUnspecifiedDomain" xlink:label="Locator_srt_ScenarioUnspecifiedDomain_1808" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_srt_StatementScenarioAxis_1807" xlink:to="Locator_srt_ScenarioUnspecifiedDomain_1808" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ScenarioUnspecifiedDomain" xlink:label="Locator_srt_ScenarioUnspecifiedDomain_1771" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_InvestmentSecuritiesTransferredFromAvailableForSaleToHeldToMaturityMember" xlink:label="Locator_uscb_InvestmentSecuritiesTransferredFromAvailableForSaleToHeldToMaturityMember_1772" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_srt_ScenarioUnspecifiedDomain_1771" xlink:to="Locator_uscb_InvestmentSecuritiesTransferredFromAvailableForSaleToHeldToMaturityMember_1772" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PledgedStatusAxis" xlink:label="Locator_us-gaap_PledgedStatusAxis_1773" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PledgedStatusDomain" xlink:label="Locator_us-gaap_PledgedStatusDomain_1774" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_PledgedStatusAxis_1773" xlink:to="Locator_us-gaap_PledgedStatusDomain_1774" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PledgedStatusAxis" xlink:label="Locator_us-gaap_PledgedStatusAxis_1805" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PledgedStatusDomain" xlink:label="Locator_us-gaap_PledgedStatusDomain_1806" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_us-gaap_PledgedStatusAxis_1805" xlink:to="Locator_us-gaap_PledgedStatusDomain_1806" order="1.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_1781" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_NumberOfInvestmentSecurities" xlink:label="Locator_uscb_NumberOfInvestmentSecurities_1782" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_1781" xlink:to="Locator_uscb_NumberOfInvestmentSecurities_1782" order="1.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_1783" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis" xlink:label="Locator_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_1784" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_1783" xlink:to="Locator_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_1784" order="2.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_1785" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:label="Locator_us-gaap_AvailableForSaleSecuritiesDebtSecurities_1786" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_1785" xlink:to="Locator_us-gaap_AvailableForSaleSecuritiesDebtSecurities_1786" order="3.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_1787" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedGainLoss" xlink:label="Locator_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedGainLoss_1788" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_1787" xlink:to="Locator_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedGainLoss_1788" order="4.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_1789" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesGrossUnrealizedLoss" xlink:label="Locator_us-gaap_AvailableForSaleDebtSecuritiesGrossUnrealizedLoss_1790" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_1789" xlink:to="Locator_us-gaap_AvailableForSaleDebtSecuritiesGrossUnrealizedLoss_1790" order="5.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_1791" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerNumberOfPositions" xlink:label="Locator_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerNumberOfPositions_1792" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_1791" xlink:to="Locator_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerNumberOfPositions_1792" order="6.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_1793" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesHeldToMaturityContinuousUnrealizedLossPosition12MonthsOrLongerNumberOfPositions" xlink:label="Locator_uscb_DebtSecuritiesHeldToMaturityContinuousUnrealizedLossPosition12MonthsOrLongerNumberOfPositions_1794" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_1793" xlink:to="Locator_uscb_DebtSecuritiesHeldToMaturityContinuousUnrealizedLossPosition12MonthsOrLongerNumberOfPositions_1794" order="7.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_1795" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecurities" xlink:label="Locator_us-gaap_DebtSecurities_1796" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_1795" xlink:to="Locator_us-gaap_DebtSecurities_1796" order="8.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_1797" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_NumberOfSecuritiesPledgedUnderAgreement" xlink:label="Locator_uscb_NumberOfSecuritiesPledgedUnderAgreement_1798" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_1797" xlink:to="Locator_uscb_NumberOfSecuritiesPledgedUnderAgreement_1798" order="9.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_1799" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_RatioOfOutstandingUninsuredDepositsForPublicDepositsSecuredBySecuritiesPledged" xlink:label="Locator_uscb_RatioOfOutstandingUninsuredDepositsForPublicDepositsSecuredBySecuritiesPledged_1800" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_1799" xlink:to="Locator_uscb_RatioOfOutstandingUninsuredDepositsForPublicDepositsSecuredBySecuritiesPledged_1800" order="10.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_1801" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentsOwnedAtFairValue" xlink:label="Locator_us-gaap_FinancialInstrumentsOwnedAtFairValue_1802" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_1801" xlink:to="Locator_us-gaap_FinancialInstrumentsOwnedAtFairValue_1802" order="11.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_1737" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable_1738" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_1737" xlink:to="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable_1738" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable_1741" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_StatementScenarioAxis" xlink:label="Locator_srt_StatementScenarioAxis_1742" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable_1741" xlink:to="Locator_srt_StatementScenarioAxis_1742" order="1.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable_1745" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis" xlink:label="Locator_srt_RangeAxis_1746" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable_1745" xlink:to="Locator_srt_RangeAxis_1746" order="3.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable_1747" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_StatementGeographicalAxis" xlink:label="Locator_srt_StatementGeographicalAxis_1748" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable_1747" xlink:to="Locator_srt_StatementGeographicalAxis_1748" order="4.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable_1749" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PledgedStatusAxis" xlink:label="Locator_us-gaap_PledgedStatusAxis_1750" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable_1749" xlink:to="Locator_us-gaap_PledgedStatusAxis_1750" order="5.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable_1751" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PledgingPurposeAxis" xlink:label="Locator_us-gaap_PledgingPurposeAxis_1752" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable_1751" xlink:to="Locator_us-gaap_PledgingPurposeAxis_1752" order="6.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable_1743" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="Locator_us-gaap_FinancialInstrumentAxis_1744" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable_1743" xlink:to="Locator_us-gaap_FinancialInstrumentAxis_1744" order="2.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/InvestmentSecuritiesAmortizedCostAndFairValueOfInvestmentSecuritiesByContractualMaturityDateDetails">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1967" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember" xlink:label="Locator_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_1968" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1967" xlink:to="Locator_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_1968" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1969" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USTreasurySecuritiesMember" xlink:label="Locator_us-gaap_USTreasurySecuritiesMember_1970" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1969" xlink:to="Locator_us-gaap_USTreasurySecuritiesMember_1970" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1971" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CollateralizedMortgageObligationsMember" xlink:label="Locator_us-gaap_CollateralizedMortgageObligationsMember_1972" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1971" xlink:to="Locator_us-gaap_CollateralizedMortgageObligationsMember_1972" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1973" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResidentialMortgageBackedSecuritiesMember" xlink:label="Locator_us-gaap_ResidentialMortgageBackedSecuritiesMember_1974" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1973" xlink:to="Locator_us-gaap_ResidentialMortgageBackedSecuritiesMember_1974" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1975" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommercialMortgageBackedSecuritiesMember" xlink:label="Locator_us-gaap_CommercialMortgageBackedSecuritiesMember_1976" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1975" xlink:to="Locator_us-gaap_CommercialMortgageBackedSecuritiesMember_1976" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="Locator_us-gaap_FinancialInstrumentAxis_1977" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1978" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_FinancialInstrumentAxis_1977" xlink:to="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1978" order="1.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_1979" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAmortizedCostAbstract" xlink:label="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAmortizedCostAbstract_1980" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_1979" xlink:to="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAmortizedCostAbstract_1980" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAmortizedCostAbstract" xlink:label="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAmortizedCostAbstract_1981" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost" xlink:label="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost_1982" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAmortizedCostAbstract_1981" xlink:to="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearAmortizedCost_1982" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAmortizedCostAbstract" xlink:label="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAmortizedCostAbstract_1983" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost" xlink:label="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost_1984" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAmortizedCostAbstract_1983" xlink:to="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsAmortizedCost_1984" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAmortizedCostAbstract" xlink:label="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAmortizedCostAbstract_1985" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsAmortizedCost" xlink:label="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsAmortizedCost_1986" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAmortizedCostAbstract_1985" xlink:to="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsAmortizedCost_1986" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAmortizedCostAbstract" xlink:label="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAmortizedCostAbstract_1987" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsAmortizedCost" xlink:label="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsAmortizedCost_1988" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAmortizedCostAbstract_1987" xlink:to="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsAmortizedCost_1988" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAmortizedCostAbstract" xlink:label="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAmortizedCostAbstract_1989" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithoutSingleMaturityDateAmortizedCost" xlink:label="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithoutSingleMaturityDateAmortizedCost_1990" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAmortizedCostAbstract_1989" xlink:to="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithoutSingleMaturityDateAmortizedCost_1990" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAmortizedCostAbstract" xlink:label="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAmortizedCostAbstract_1991" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis" xlink:label="Locator_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_1992" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAmortizedCostAbstract_1991" xlink:to="Locator_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_1992" order="6.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_1993" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesFairValueAbstract" xlink:label="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesFairValueAbstract_1994" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_1993" xlink:to="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesFairValueAbstract_1994" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesFairValueAbstract" xlink:label="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesFairValueAbstract_1995" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue" xlink:label="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_1996" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesFairValueAbstract_1995" xlink:to="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_1996" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesFairValueAbstract" xlink:label="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesFairValueAbstract_1997" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue" xlink:label="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_1998" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesFairValueAbstract_1997" xlink:to="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_1998" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesFairValueAbstract" xlink:label="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesFairValueAbstract_1999" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue" xlink:label="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue_2000" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesFairValueAbstract_1999" xlink:to="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue_2000" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesFairValueAbstract" xlink:label="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesFairValueAbstract_2001" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsFairValue" xlink:label="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsFairValue_2002" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesFairValueAbstract_2001" xlink:to="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterTenYearsFairValue_2002" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesFairValueAbstract" xlink:label="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesFairValueAbstract_2003" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithoutSingleMaturityDateFairValue" xlink:label="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithoutSingleMaturityDateFairValue_2004" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesFairValueAbstract_2003" xlink:to="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithoutSingleMaturityDateFairValue_2004" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesFairValueAbstract" xlink:label="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesFairValueAbstract_2005" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:label="Locator_us-gaap_AvailableForSaleSecuritiesDebtSecurities_2006" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesFairValueAbstract_2005" xlink:to="Locator_us-gaap_AvailableForSaleSecuritiesDebtSecurities_2006" order="6.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_2007" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesNetCarryingAmountAbstract" xlink:label="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesNetCarryingAmountAbstract_2008" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_2007" xlink:to="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesNetCarryingAmountAbstract_2008" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesNetCarryingAmountAbstract" xlink:label="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesNetCarryingAmountAbstract_2009" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearNetCarryingAmount" xlink:label="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearNetCarryingAmount_2010" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesNetCarryingAmountAbstract_2009" xlink:to="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearNetCarryingAmount_2010" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesNetCarryingAmountAbstract" xlink:label="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesNetCarryingAmountAbstract_2011" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterOneThroughFiveYearsNetCarryingAmount" xlink:label="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterOneThroughFiveYearsNetCarryingAmount_2012" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesNetCarryingAmountAbstract_2011" xlink:to="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterOneThroughFiveYearsNetCarryingAmount_2012" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesNetCarryingAmountAbstract" xlink:label="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesNetCarryingAmountAbstract_2013" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterFiveThroughTenYearsNetCarryingAmount" xlink:label="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterFiveThroughTenYearsNetCarryingAmount_2014" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesNetCarryingAmountAbstract_2013" xlink:to="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterFiveThroughTenYearsNetCarryingAmount_2014" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesNetCarryingAmountAbstract" xlink:label="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesNetCarryingAmountAbstract_2015" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterTenYearsNetCarryingAmount" xlink:label="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterTenYearsNetCarryingAmount_2016" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesNetCarryingAmountAbstract_2015" xlink:to="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterTenYearsNetCarryingAmount_2016" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesNetCarryingAmountAbstract" xlink:label="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesNetCarryingAmountAbstract_2017" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithoutSingleMaturityDateNetCarryingAmount" xlink:label="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithoutSingleMaturityDateNetCarryingAmount_2018" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesNetCarryingAmountAbstract_2017" xlink:to="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithoutSingleMaturityDateNetCarryingAmount_2018" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesNetCarryingAmountAbstract" xlink:label="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesNetCarryingAmountAbstract_2019" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesHeldToMaturityAmortizedCostAfterAllowanceForCreditLoss" xlink:label="Locator_us-gaap_DebtSecuritiesHeldToMaturityAmortizedCostAfterAllowanceForCreditLoss_2020" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesNetCarryingAmountAbstract_2019" xlink:to="Locator_us-gaap_DebtSecuritiesHeldToMaturityAmortizedCostAfterAllowanceForCreditLoss_2020" order="6.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_2021" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesFairValueAbstract" xlink:label="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesFairValueAbstract_2022" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_2021" xlink:to="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesFairValueAbstract_2022" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesFairValueAbstract" xlink:label="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesFairValueAbstract_2023" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearFairValue" xlink:label="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearFairValue_2024" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesFairValueAbstract_2023" xlink:to="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithinOneYearFairValue_2024" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesFairValueAbstract" xlink:label="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesFairValueAbstract_2025" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue" xlink:label="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_2026" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesFairValueAbstract_2025" xlink:to="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_2026" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesFairValueAbstract" xlink:label="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesFairValueAbstract_2027" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue" xlink:label="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue_2028" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesFairValueAbstract_2027" xlink:to="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue_2028" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesFairValueAbstract" xlink:label="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesFairValueAbstract_2029" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterTenYearsFairValue" xlink:label="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterTenYearsFairValue_2030" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesFairValueAbstract_2029" xlink:to="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesAfterTenYearsFairValue_2030" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesFairValueAbstract" xlink:label="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesFairValueAbstract_2031" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithoutSingleMaturityDateFairValue" xlink:label="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithoutSingleMaturityDateFairValue_2032" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesFairValueAbstract_2031" xlink:to="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesWithoutSingleMaturityDateFairValue_2032" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecuritiesDebtMaturitiesFairValueAbstract" xlink:label="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesFairValueAbstract_2033" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecuritiesFairValue" xlink:label="Locator_us-gaap_HeldToMaturitySecuritiesFairValue_2034" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_HeldToMaturitySecuritiesDebtMaturitiesFairValueAbstract_2033" xlink:to="Locator_us-gaap_HeldToMaturitySecuritiesFairValue_2034" order="6.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_1873" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable_1874" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_1873" xlink:to="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable_1874" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable_1965" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="Locator_us-gaap_FinancialInstrumentAxis_1966" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable_1965" xlink:to="Locator_us-gaap_FinancialInstrumentAxis_1966" order="1.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/EarningsPerShareNarrativeDetails">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="Locator_us-gaap_StatementClassOfStockAxis_2061" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_2062" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_StatementClassOfStockAxis_2061" xlink:to="Locator_us-gaap_ClassOfStockDomain_2062" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_2065" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassBMember" xlink:label="Locator_us-gaap_CommonClassBMember_2066" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockDomain_2065" xlink:to="Locator_us-gaap_CommonClassBMember_2066" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_2063" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassAMember" xlink:label="Locator_us-gaap_CommonClassAMember_2064" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockDomain_2063" xlink:to="Locator_us-gaap_CommonClassAMember_2064" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareBasicLineItems" xlink:label="Locator_us-gaap_EarningsPerShareBasicLineItems_2067" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesIssued" xlink:label="Locator_us-gaap_CommonStockSharesIssued_2068" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_EarningsPerShareBasicLineItems_2067" xlink:to="Locator_us-gaap_CommonStockSharesIssued_2068" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareBasicLineItems" xlink:label="Locator_us-gaap_EarningsPerShareBasicLineItems_2069" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesOutstanding" xlink:label="Locator_us-gaap_CommonStockSharesOutstanding_2070" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_EarningsPerShareBasicLineItems_2069" xlink:to="Locator_us-gaap_CommonStockSharesOutstanding_2070" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareBasicLineItems" xlink:label="Locator_us-gaap_EarningsPerShareBasicLineItems_2055" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfEarningsPerShareBasicByCommonClassTable" xlink:label="Locator_us-gaap_ScheduleOfEarningsPerShareBasicByCommonClassTable_2056" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_us-gaap_EarningsPerShareBasicLineItems_2055" xlink:to="Locator_us-gaap_ScheduleOfEarningsPerShareBasicByCommonClassTable_2056" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfEarningsPerShareBasicByCommonClassTable" xlink:label="Locator_us-gaap_ScheduleOfEarningsPerShareBasicByCommonClassTable_2059" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="Locator_us-gaap_StatementClassOfStockAxis_2060" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_ScheduleOfEarningsPerShareBasicByCommonClassTable_2059" xlink:to="Locator_us-gaap_StatementClassOfStockAxis_2060" order="1.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/EarningsPerShareCalculationOfBasicAndDilutedEarningsLossPerCommonShareClassDetails">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="Locator_us-gaap_StatementClassOfStockAxis_2123" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_2124" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_StatementClassOfStockAxis_2123" xlink:to="Locator_us-gaap_ClassOfStockDomain_2124" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_2127" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassBMember" xlink:label="Locator_us-gaap_CommonClassBMember_2128" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockDomain_2127" xlink:to="Locator_us-gaap_CommonClassBMember_2128" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_2125" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassAMember" xlink:label="Locator_us-gaap_CommonClassAMember_2126" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockDomain_2125" xlink:to="Locator_us-gaap_CommonClassAMember_2126" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareBasicLineItems" xlink:label="Locator_us-gaap_EarningsPerShareBasicLineItems_2101" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfEarningsPerShareBasicByCommonClassTable" xlink:label="Locator_us-gaap_ScheduleOfEarningsPerShareBasicByCommonClassTable_2102" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_us-gaap_EarningsPerShareBasicLineItems_2101" xlink:to="Locator_us-gaap_ScheduleOfEarningsPerShareBasicByCommonClassTable_2102" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfEarningsPerShareBasicByCommonClassTable" xlink:label="Locator_us-gaap_ScheduleOfEarningsPerShareBasicByCommonClassTable_2121" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="Locator_us-gaap_StatementClassOfStockAxis_2122" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_ScheduleOfEarningsPerShareBasicByCommonClassTable_2121" xlink:to="Locator_us-gaap_StatementClassOfStockAxis_2122" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareBasicLineItems" xlink:label="Locator_us-gaap_EarningsPerShareBasicLineItems_2129" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasicAbstract" xlink:label="Locator_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasicAbstract_2130" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_EarningsPerShareBasicLineItems_2129" xlink:to="Locator_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasicAbstract_2130" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasicAbstract" xlink:label="Locator_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasicAbstract_2131" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic" xlink:label="Locator_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_2132" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasicAbstract_2131" xlink:to="Locator_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic_2132" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasicAbstract" xlink:label="Locator_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasicAbstract_2133" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_PercentAllocatedOnWeightedAverageSharesOutstanding" xlink:label="Locator_uscb_PercentAllocatedOnWeightedAverageSharesOutstanding_2134" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasicAbstract_2133" xlink:to="Locator_uscb_PercentAllocatedOnWeightedAverageSharesOutstanding_2134" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasicAbstract" xlink:label="Locator_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasicAbstract_2135" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_NetIncomeLossAvailableToCommonStockholdersAfterAllocation" xlink:label="Locator_uscb_NetIncomeLossAvailableToCommonStockholdersAfterAllocation_2136" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasicAbstract_2135" xlink:to="Locator_uscb_NetIncomeLossAvailableToCommonStockholdersAfterAllocation_2136" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasicAbstract" xlink:label="Locator_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasicAbstract_2137" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic" xlink:label="Locator_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_2138" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasicAbstract_2137" xlink:to="Locator_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_2138" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersBasicAbstract" xlink:label="Locator_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasicAbstract_2139" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareBasic" xlink:label="Locator_us-gaap_EarningsPerShareBasic_2140" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetIncomeLossAvailableToCommonStockholdersBasicAbstract_2139" xlink:to="Locator_us-gaap_EarningsPerShareBasic_2140" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareBasicLineItems" xlink:label="Locator_us-gaap_EarningsPerShareBasicLineItems_2141" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersDilutedAbstract" xlink:label="Locator_us-gaap_NetIncomeLossAvailableToCommonStockholdersDilutedAbstract_2142" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_EarningsPerShareBasicLineItems_2141" xlink:to="Locator_us-gaap_NetIncomeLossAvailableToCommonStockholdersDilutedAbstract_2142" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersDilutedAbstract" xlink:label="Locator_us-gaap_NetIncomeLossAvailableToCommonStockholdersDilutedAbstract_2143" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements" xlink:label="Locator_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_2144" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetIncomeLossAvailableToCommonStockholdersDilutedAbstract_2143" xlink:to="Locator_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_2144" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersDilutedAbstract" xlink:label="Locator_us-gaap_NetIncomeLossAvailableToCommonStockholdersDilutedAbstract_2145" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding" xlink:label="Locator_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_2146" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetIncomeLossAvailableToCommonStockholdersDilutedAbstract_2145" xlink:to="Locator_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_2146" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAvailableToCommonStockholdersDilutedAbstract" xlink:label="Locator_us-gaap_NetIncomeLossAvailableToCommonStockholdersDilutedAbstract_2147" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareDiluted" xlink:label="Locator_us-gaap_EarningsPerShareDiluted_2148" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetIncomeLossAvailableToCommonStockholdersDilutedAbstract_2147" xlink:to="Locator_us-gaap_EarningsPerShareDiluted_2148" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareBasicLineItems" xlink:label="Locator_us-gaap_EarningsPerShareBasicLineItems_2149" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount" xlink:label="Locator_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_2150" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_EarningsPerShareBasicLineItems_2149" xlink:to="Locator_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_2150" order="3.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/RegulatoryMattersNarrativeDetails">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesAxis" xlink:label="Locator_srt_ConsolidatedEntitiesAxis_2167" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesDomain" xlink:label="Locator_srt_ConsolidatedEntitiesDomain_2168" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_srt_ConsolidatedEntitiesAxis_2167" xlink:to="Locator_srt_ConsolidatedEntitiesDomain_2168" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesDomain" xlink:label="Locator_srt_ConsolidatedEntitiesDomain_2169" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SubsidiariesMember" xlink:label="Locator_srt_SubsidiariesMember_2170" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_srt_ConsolidatedEntitiesDomain_2169" xlink:to="Locator_srt_SubsidiariesMember_2170" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems" xlink:label="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_2171" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsTable" xlink:label="Locator_us-gaap_ScheduleOfComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsTable_2172" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_2171" xlink:to="Locator_us-gaap_ScheduleOfComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsTable_2172" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsTable" xlink:label="Locator_us-gaap_ScheduleOfComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsTable_2173" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesAxis" xlink:label="Locator_srt_ConsolidatedEntitiesAxis_2174" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_ScheduleOfComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsTable_2173" xlink:to="Locator_srt_ConsolidatedEntitiesAxis_2174" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems" xlink:label="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_2175" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockParOrStatedValuePerShare" xlink:label="Locator_us-gaap_CommonStockParOrStatedValuePerShare_2176" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ComplianceWithRegulatoryCapitalRequirementsUnderBankingRegulationsLineItems_2175" xlink:to="Locator_us-gaap_CommonStockParOrStatedValuePerShare_2176" order="1.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/InvestmentSecuritiesAvailableforSaleSecuritiesContinuousUnrealizedLossPositionFairValueDetails">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_2205" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember" xlink:label="Locator_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_2206" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_2205" xlink:to="Locator_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_2206" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_2207" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USTreasurySecuritiesMember" xlink:label="Locator_us-gaap_USTreasurySecuritiesMember_2208" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_2207" xlink:to="Locator_us-gaap_USTreasurySecuritiesMember_2208" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_2209" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CollateralizedMortgageObligationsMember" xlink:label="Locator_us-gaap_CollateralizedMortgageObligationsMember_2210" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_2209" xlink:to="Locator_us-gaap_CollateralizedMortgageObligationsMember_2210" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_2211" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResidentialMortgageBackedSecuritiesMember" xlink:label="Locator_us-gaap_ResidentialMortgageBackedSecuritiesMember_2212" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_2211" xlink:to="Locator_us-gaap_ResidentialMortgageBackedSecuritiesMember_2212" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_2213" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommercialMortgageBackedSecuritiesMember" xlink:label="Locator_us-gaap_CommercialMortgageBackedSecuritiesMember_2214" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_2213" xlink:to="Locator_us-gaap_CommercialMortgageBackedSecuritiesMember_2214" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_2215" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USStatesAndPoliticalSubdivisionsMember" xlink:label="Locator_us-gaap_USStatesAndPoliticalSubdivisionsMember_2216" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_2215" xlink:to="Locator_us-gaap_USStatesAndPoliticalSubdivisionsMember_2216" order="6.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_2217" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_BankSubordinatedDebtSecuritiesMember" xlink:label="Locator_uscb_BankSubordinatedDebtSecuritiesMember_2218" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_2217" xlink:to="Locator_uscb_BankSubordinatedDebtSecuritiesMember_2218" order="7.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_2219" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CorporateBondSecuritiesMember" xlink:label="Locator_us-gaap_CorporateBondSecuritiesMember_2220" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_2219" xlink:to="Locator_us-gaap_CorporateBondSecuritiesMember_2220" order="8.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="Locator_us-gaap_FinancialInstrumentAxis_2221" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_2222" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_FinancialInstrumentAxis_2221" xlink:to="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_2222" order="1.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_2199" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable_2200" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_2199" xlink:to="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable_2200" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable_2203" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="Locator_us-gaap_FinancialInstrumentAxis_2204" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityTable_2203" xlink:to="Locator_us-gaap_FinancialInstrumentAxis_2204" order="1.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_2223" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months" xlink:label="Locator_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_2224" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_2223" xlink:to="Locator_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_2224" order="1.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_2225" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss" xlink:label="Locator_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_2226" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_2225" xlink:to="Locator_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_2226" order="2.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_2227" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger" xlink:label="Locator_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_2228" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_2227" xlink:to="Locator_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_2228" order="3.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_2229" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss" xlink:label="Locator_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_2230" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_2229" xlink:to="Locator_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_2230" order="4.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_2231" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition" xlink:label="Locator_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_2232" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_2231" xlink:to="Locator_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_2232" order="5.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems" xlink:label="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_2233" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss" xlink:label="Locator_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_2234" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_DebtSecuritiesAvailableForSaleAndHeldToMaturityLineItems_2233" xlink:to="Locator_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_2234" order="6.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/StockholdersEquityNarrativeDetails">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockLineItems" xlink:label="Locator_us-gaap_ClassOfStockLineItems_2431" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable" xlink:label="Locator_us-gaap_StatementTable_2432" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_us-gaap_ClassOfStockLineItems_2431" xlink:to="Locator_us-gaap_StatementTable_2432" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable" xlink:label="Locator_us-gaap_StatementTable_2435" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="Locator_us-gaap_StatementClassOfStockAxis_2436" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_StatementTable_2435" xlink:to="Locator_us-gaap_StatementClassOfStockAxis_2436" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="Locator_us-gaap_StatementClassOfStockAxis_2443" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_2444" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_StatementClassOfStockAxis_2443" xlink:to="Locator_us-gaap_ClassOfStockDomain_2444" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_2447" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassBMember" xlink:label="Locator_us-gaap_CommonClassBMember_2448" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockDomain_2447" xlink:to="Locator_us-gaap_CommonClassBMember_2448" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_2455" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_ClassCPreferredStockAndClassDPreferredStockMember" xlink:label="Locator_uscb_ClassCPreferredStockAndClassDPreferredStockMember_2456" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockDomain_2455" xlink:to="Locator_uscb_ClassCPreferredStockAndClassDPreferredStockMember_2456" order="6.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_2457" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockMember" xlink:label="Locator_us-gaap_PreferredStockMember_2458" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockDomain_2457" xlink:to="Locator_us-gaap_PreferredStockMember_2458" order="7.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_2459" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockMember" xlink:label="Locator_us-gaap_CommonStockMember_2460" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockDomain_2459" xlink:to="Locator_us-gaap_CommonStockMember_2460" order="8.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_2449" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SeriesCPreferredStockMember" xlink:label="Locator_us-gaap_SeriesCPreferredStockMember_2450" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockDomain_2449" xlink:to="Locator_us-gaap_SeriesCPreferredStockMember_2450" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_2451" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SeriesDPreferredStockMember" xlink:label="Locator_us-gaap_SeriesDPreferredStockMember_2452" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockDomain_2451" xlink:to="Locator_us-gaap_SeriesDPreferredStockMember_2452" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_2453" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SeriesEPreferredStockMember" xlink:label="Locator_us-gaap_SeriesEPreferredStockMember_2454" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockDomain_2453" xlink:to="Locator_us-gaap_SeriesEPreferredStockMember_2454" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_2445" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassAMember" xlink:label="Locator_us-gaap_CommonClassAMember_2446" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockDomain_2445" xlink:to="Locator_us-gaap_CommonClassAMember_2446" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable" xlink:label="Locator_us-gaap_StatementTable_2437" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsidiarySaleOfStockAxis" xlink:label="Locator_us-gaap_SubsidiarySaleOfStockAxis_2438" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_StatementTable_2437" xlink:to="Locator_us-gaap_SubsidiarySaleOfStockAxis_2438" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsidiarySaleOfStockAxis" xlink:label="Locator_us-gaap_SubsidiarySaleOfStockAxis_2461" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleOfStockNameOfTransactionDomain" xlink:label="Locator_us-gaap_SaleOfStockNameOfTransactionDomain_2462" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_SubsidiarySaleOfStockAxis_2461" xlink:to="Locator_us-gaap_SaleOfStockNameOfTransactionDomain_2462" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsidiarySaleOfStockAxis" xlink:label="Locator_us-gaap_SubsidiarySaleOfStockAxis_2511" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleOfStockNameOfTransactionDomain" xlink:label="Locator_us-gaap_SaleOfStockNameOfTransactionDomain_2512" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_us-gaap_SubsidiarySaleOfStockAxis_2511" xlink:to="Locator_us-gaap_SaleOfStockNameOfTransactionDomain_2512" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleOfStockNameOfTransactionDomain" xlink:label="Locator_us-gaap_SaleOfStockNameOfTransactionDomain_2463" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IPOMember" xlink:label="Locator_us-gaap_IPOMember_2464" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_SaleOfStockNameOfTransactionDomain_2463" xlink:to="Locator_us-gaap_IPOMember_2464" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable" xlink:label="Locator_us-gaap_StatementTable_2439" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesAxis" xlink:label="Locator_srt_ConsolidatedEntitiesAxis_2440" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_StatementTable_2439" xlink:to="Locator_srt_ConsolidatedEntitiesAxis_2440" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesAxis" xlink:label="Locator_srt_ConsolidatedEntitiesAxis_2465" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesDomain" xlink:label="Locator_srt_ConsolidatedEntitiesDomain_2466" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_srt_ConsolidatedEntitiesAxis_2465" xlink:to="Locator_srt_ConsolidatedEntitiesDomain_2466" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesDomain" xlink:label="Locator_srt_ConsolidatedEntitiesDomain_2467" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SubsidiariesMember" xlink:label="Locator_srt_SubsidiariesMember_2468" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_srt_ConsolidatedEntitiesDomain_2467" xlink:to="Locator_srt_SubsidiariesMember_2468" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable" xlink:label="Locator_us-gaap_StatementTable_2441" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="Locator_us-gaap_SubsequentEventTypeAxis_2442" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_StatementTable_2441" xlink:to="Locator_us-gaap_SubsequentEventTypeAxis_2442" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="Locator_us-gaap_SubsequentEventTypeAxis_2469" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="Locator_us-gaap_SubsequentEventTypeDomain_2470" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_SubsequentEventTypeAxis_2469" xlink:to="Locator_us-gaap_SubsequentEventTypeDomain_2470" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="Locator_us-gaap_SubsequentEventTypeDomain_2471" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventMember" xlink:label="Locator_us-gaap_SubsequentEventMember_2472" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_SubsequentEventTypeDomain_2471" xlink:to="Locator_us-gaap_SubsequentEventMember_2472" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockLineItems" xlink:label="Locator_us-gaap_ClassOfStockLineItems_2473" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockVotingRights" xlink:label="Locator_us-gaap_CommonStockVotingRights_2474" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockLineItems_2473" xlink:to="Locator_us-gaap_CommonStockVotingRights_2474" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockLineItems" xlink:label="Locator_us-gaap_ClassOfStockLineItems_2475" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesIssued" xlink:label="Locator_us-gaap_CommonStockSharesIssued_2476" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockLineItems_2475" xlink:to="Locator_us-gaap_CommonStockSharesIssued_2476" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockLineItems" xlink:label="Locator_us-gaap_ClassOfStockLineItems_2477" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues" xlink:label="Locator_us-gaap_StockIssuedDuringPeriodSharesNewIssues_2478" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockLineItems_2477" xlink:to="Locator_us-gaap_StockIssuedDuringPeriodSharesNewIssues_2478" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockLineItems" xlink:label="Locator_us-gaap_ClassOfStockLineItems_2479" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceInitialPublicOffering" xlink:label="Locator_us-gaap_ProceedsFromIssuanceInitialPublicOffering_2480" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockLineItems_2479" xlink:to="Locator_us-gaap_ProceedsFromIssuanceInitialPublicOffering_2480" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockLineItems" xlink:label="Locator_us-gaap_ClassOfStockLineItems_2481" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharesIssuedPricePerShare" xlink:label="Locator_us-gaap_SharesIssuedPricePerShare_2482" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockLineItems_2481" xlink:to="Locator_us-gaap_SharesIssuedPricePerShare_2482" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockLineItems" xlink:label="Locator_us-gaap_ClassOfStockLineItems_2483" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockConvertibleConversionRatio" xlink:label="Locator_us-gaap_PreferredStockConvertibleConversionRatio_2484" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockLineItems_2483" xlink:to="Locator_us-gaap_PreferredStockConvertibleConversionRatio_2484" order="6.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockLineItems" xlink:label="Locator_us-gaap_ClassOfStockLineItems_2485" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_PreferredStockRemainingConversionRatioToBeRedeemedInFormOfCash" xlink:label="Locator_uscb_PreferredStockRemainingConversionRatioToBeRedeemedInFormOfCash_2486" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockLineItems_2485" xlink:to="Locator_uscb_PreferredStockRemainingConversionRatioToBeRedeemedInFormOfCash_2486" order="7.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockLineItems" xlink:label="Locator_us-gaap_ClassOfStockLineItems_2487" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConvertiblePreferredStockSharesIssuedUponConversion" xlink:label="Locator_us-gaap_ConvertiblePreferredStockSharesIssuedUponConversion_2488" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockLineItems_2487" xlink:to="Locator_us-gaap_ConvertiblePreferredStockSharesIssuedUponConversion_2488" order="8.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockLineItems" xlink:label="Locator_us-gaap_ClassOfStockLineItems_2489" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConversionOfStockSharesIssued1" xlink:label="Locator_us-gaap_ConversionOfStockSharesIssued1_2490" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockLineItems_2489" xlink:to="Locator_us-gaap_ConversionOfStockSharesIssued1_2490" order="9.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockLineItems" xlink:label="Locator_us-gaap_ClassOfStockLineItems_2491" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockLiquidationPreferenceValue" xlink:label="Locator_us-gaap_PreferredStockLiquidationPreferenceValue_2492" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockLineItems_2491" xlink:to="Locator_us-gaap_PreferredStockLiquidationPreferenceValue_2492" order="10.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockLineItems" xlink:label="Locator_us-gaap_ClassOfStockLineItems_2493" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss" xlink:label="Locator_us-gaap_NetIncomeLoss_2494" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockLineItems_2493" xlink:to="Locator_us-gaap_NetIncomeLoss_2494" order="11.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockLineItems" xlink:label="Locator_us-gaap_ClassOfStockLineItems_2495" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DividendsPayableCurrentAndNoncurrent" xlink:label="Locator_us-gaap_DividendsPayableCurrentAndNoncurrent_2496" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockLineItems_2495" xlink:to="Locator_us-gaap_DividendsPayableCurrentAndNoncurrent_2496" order="12.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockLineItems" xlink:label="Locator_us-gaap_ClassOfStockLineItems_2497" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockSharesIssued" xlink:label="Locator_us-gaap_PreferredStockSharesIssued_2498" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockLineItems_2497" xlink:to="Locator_us-gaap_PreferredStockSharesIssued_2498" order="13.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockLineItems" xlink:label="Locator_us-gaap_ClassOfStockLineItems_2499" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DividendsPreferredStockStock" xlink:label="Locator_us-gaap_DividendsPreferredStockStock_2500" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockLineItems_2499" xlink:to="Locator_us-gaap_DividendsPreferredStockStock_2500" order="14.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockLineItems" xlink:label="Locator_us-gaap_ClassOfStockLineItems_2501" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockParOrStatedValuePerShare" xlink:label="Locator_us-gaap_CommonStockParOrStatedValuePerShare_2502" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockLineItems_2501" xlink:to="Locator_us-gaap_CommonStockParOrStatedValuePerShare_2502" order="15.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockLineItems" xlink:label="Locator_us-gaap_ClassOfStockLineItems_2503" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityReverseStockSplit" xlink:label="Locator_us-gaap_StockholdersEquityReverseStockSplit_2504" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockLineItems_2503" xlink:to="Locator_us-gaap_StockholdersEquityReverseStockSplit_2504" order="16.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockLineItems" xlink:label="Locator_us-gaap_ClassOfStockLineItems_2505" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityNoteStockSplitConversionRatio1" xlink:label="Locator_us-gaap_StockholdersEquityNoteStockSplitConversionRatio1_2506" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockLineItems_2505" xlink:to="Locator_us-gaap_StockholdersEquityNoteStockSplitConversionRatio1_2506" order="17.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockLineItems" xlink:label="Locator_us-gaap_ClassOfStockLineItems_2507" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockSharesOutstanding" xlink:label="Locator_us-gaap_PreferredStockSharesOutstanding_2508" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockLineItems_2507" xlink:to="Locator_us-gaap_PreferredStockSharesOutstanding_2508" order="18.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockLineItems" xlink:label="Locator_us-gaap_ClassOfStockLineItems_2509" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_ConversionOfStockSharesIssuedConvertedFrom" xlink:label="Locator_uscb_ConversionOfStockSharesIssuedConvertedFrom_2510" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockLineItems_2509" xlink:to="Locator_uscb_ConversionOfStockSharesIssuedConvertedFrom_2510" order="19.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/StockholdersEquityScheduleOfDividendsOnPreferredSharesDetails">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="Locator_us-gaap_StatementClassOfStockAxis_2563" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_2564" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_StatementClassOfStockAxis_2563" xlink:to="Locator_us-gaap_ClassOfStockDomain_2564" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_2565" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SeriesCPreferredStockMember" xlink:label="Locator_us-gaap_SeriesCPreferredStockMember_2566" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockDomain_2565" xlink:to="Locator_us-gaap_SeriesCPreferredStockMember_2566" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_2567" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SeriesDPreferredStockMember" xlink:label="Locator_us-gaap_SeriesDPreferredStockMember_2568" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockDomain_2567" xlink:to="Locator_us-gaap_SeriesDPreferredStockMember_2568" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_2569" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SeriesEPreferredStockMember" xlink:label="Locator_us-gaap_SeriesEPreferredStockMember_2570" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockDomain_2569" xlink:to="Locator_us-gaap_SeriesEPreferredStockMember_2570" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockLineItems" xlink:label="Locator_us-gaap_ClassOfStockLineItems_2571" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfStockByClassTable" xlink:label="Locator_us-gaap_ScheduleOfStockByClassTable_2572" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_us-gaap_ClassOfStockLineItems_2571" xlink:to="Locator_us-gaap_ScheduleOfStockByClassTable_2572" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfStockByClassTable" xlink:label="Locator_us-gaap_ScheduleOfStockByClassTable_2573" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="Locator_us-gaap_StatementClassOfStockAxis_2574" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_ScheduleOfStockByClassTable_2573" xlink:to="Locator_us-gaap_StatementClassOfStockAxis_2574" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfStockByClassTable" xlink:label="Locator_us-gaap_ScheduleOfStockByClassTable_2575" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredUnitsByNameAxis" xlink:label="Locator_us-gaap_PreferredUnitsByNameAxis_2576" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_ScheduleOfStockByClassTable_2575" xlink:to="Locator_us-gaap_PreferredUnitsByNameAxis_2576" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredUnitsByNameAxis" xlink:label="Locator_us-gaap_PreferredUnitsByNameAxis_2577" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredUnitsClassDomain" xlink:label="Locator_us-gaap_PreferredUnitsClassDomain_2578" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_PreferredUnitsByNameAxis_2577" xlink:to="Locator_us-gaap_PreferredUnitsClassDomain_2578" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredUnitsByNameAxis" xlink:label="Locator_us-gaap_PreferredUnitsByNameAxis_2579" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredUnitsClassDomain" xlink:label="Locator_us-gaap_PreferredUnitsClassDomain_2580" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_us-gaap_PreferredUnitsByNameAxis_2579" xlink:to="Locator_us-gaap_PreferredUnitsClassDomain_2580" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredUnitsClassDomain" xlink:label="Locator_us-gaap_PreferredUnitsClassDomain_2581" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_NonVotingNonCumulativePerpetualPreferredStockMember" xlink:label="Locator_uscb_NonVotingNonCumulativePerpetualPreferredStockMember_2582" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_PreferredUnitsClassDomain_2581" xlink:to="Locator_uscb_NonVotingNonCumulativePerpetualPreferredStockMember_2582" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockLineItems" xlink:label="Locator_us-gaap_ClassOfStockLineItems_2583" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DividendsPreferredStockCash" xlink:label="Locator_us-gaap_DividendsPreferredStockCash_2584" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockLineItems_2583" xlink:to="Locator_us-gaap_DividendsPreferredStockCash_2584" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockLineItems" xlink:label="Locator_us-gaap_ClassOfStockLineItems_2585" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockParOrStatedValuePerShare" xlink:label="Locator_us-gaap_PreferredStockParOrStatedValuePerShare_2586" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockLineItems_2585" xlink:to="Locator_us-gaap_PreferredStockParOrStatedValuePerShare_2586" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockLineItems" xlink:label="Locator_us-gaap_ClassOfStockLineItems_2587" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockLiquidationPreference" xlink:label="Locator_us-gaap_PreferredStockLiquidationPreference_2588" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockLineItems_2587" xlink:to="Locator_us-gaap_PreferredStockLiquidationPreference_2588" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockLineItems" xlink:label="Locator_us-gaap_ClassOfStockLineItems_2589" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockDividendRatePercentage" xlink:label="Locator_us-gaap_PreferredStockDividendRatePercentage_2590" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockLineItems_2589" xlink:to="Locator_us-gaap_PreferredStockDividendRatePercentage_2590" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockLineItems" xlink:label="Locator_us-gaap_ClassOfStockLineItems_2591" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockDividendsPerShareCashPaid" xlink:label="Locator_us-gaap_PreferredStockDividendsPerShareCashPaid_2592" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockLineItems_2591" xlink:to="Locator_us-gaap_PreferredStockDividendsPerShareCashPaid_2592" order="5.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/OffBalanceSheetArrangementsScheduleOfFinancialsInstrumentsWithOffBalanceSheetRiskDetails">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_2617" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsToExtendCreditMember" xlink:label="Locator_us-gaap_CommitmentsToExtendCreditMember_2618" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_2617" xlink:to="Locator_us-gaap_CommitmentsToExtendCreditMember_2618" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_2619" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_StandbyAndCommercialLettersOfCreditMember" xlink:label="Locator_uscb_StandbyAndCommercialLettersOfCreditMember_2620" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_2619" xlink:to="Locator_uscb_StandbyAndCommercialLettersOfCreditMember_2620" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="Locator_us-gaap_FinancialInstrumentAxis_2621" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_2622" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_FinancialInstrumentAxis_2621" xlink:to="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_2622" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueOffBalanceSheetRisksDisclosureInformationLineItems" xlink:label="Locator_us-gaap_FairValueOffBalanceSheetRisksDisclosureInformationLineItems_2623" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfFairValueOffBalanceSheetRisksTable" xlink:label="Locator_us-gaap_ScheduleOfFairValueOffBalanceSheetRisksTable_2624" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_us-gaap_FairValueOffBalanceSheetRisksDisclosureInformationLineItems_2623" xlink:to="Locator_us-gaap_ScheduleOfFairValueOffBalanceSheetRisksTable_2624" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfFairValueOffBalanceSheetRisksTable" xlink:label="Locator_us-gaap_ScheduleOfFairValueOffBalanceSheetRisksTable_2625" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="Locator_us-gaap_FinancialInstrumentAxis_2626" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_ScheduleOfFairValueOffBalanceSheetRisksTable_2625" xlink:to="Locator_us-gaap_FinancialInstrumentAxis_2626" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueOffBalanceSheetRisksDisclosureInformationLineItems" xlink:label="Locator_us-gaap_FairValueOffBalanceSheetRisksDisclosureInformationLineItems_2627" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueDisclosureOffbalanceSheetRisksFaceAmountLiability" xlink:label="Locator_us-gaap_FairValueDisclosureOffbalanceSheetRisksFaceAmountLiability_2628" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FairValueOffBalanceSheetRisksDisclosureInformationLineItems_2627" xlink:to="Locator_us-gaap_FairValueDisclosureOffbalanceSheetRisksFaceAmountLiability_2628" order="1.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/DerivativesNarrativeDetails">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativesFairValueLineItems" xlink:label="Locator_us-gaap_DerivativesFairValueLineItems_2647" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeNumberOfInstrumentsHeld" xlink:label="Locator_us-gaap_DerivativeNumberOfInstrumentsHeld_2648" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_DerivativesFairValueLineItems_2647" xlink:to="Locator_us-gaap_DerivativeNumberOfInstrumentsHeld_2648" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativesFairValueLineItems" xlink:label="Locator_us-gaap_DerivativesFairValueLineItems_2649" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable" xlink:label="Locator_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_2650" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_us-gaap_DerivativesFairValueLineItems_2649" xlink:to="Locator_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_2650" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable" xlink:label="Locator_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_2651" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="Locator_us-gaap_DerivativeInstrumentRiskAxis_2652" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_2651" xlink:to="Locator_us-gaap_DerivativeInstrumentRiskAxis_2652" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="Locator_us-gaap_DerivativeInstrumentRiskAxis_2653" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="Locator_us-gaap_DerivativeContractTypeDomain_2654" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_DerivativeInstrumentRiskAxis_2653" xlink:to="Locator_us-gaap_DerivativeContractTypeDomain_2654" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="Locator_us-gaap_DerivativeInstrumentRiskAxis_2655" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="Locator_us-gaap_DerivativeContractTypeDomain_2656" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_us-gaap_DerivativeInstrumentRiskAxis_2655" xlink:to="Locator_us-gaap_DerivativeContractTypeDomain_2656" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="Locator_us-gaap_DerivativeContractTypeDomain_2657" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestRateSwapMember" xlink:label="Locator_us-gaap_InterestRateSwapMember_2658" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_DerivativeContractTypeDomain_2657" xlink:to="Locator_us-gaap_InterestRateSwapMember_2658" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativesFairValueLineItems" xlink:label="Locator_us-gaap_DerivativesFairValueLineItems_2659" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeNotionalAmount" xlink:label="Locator_us-gaap_DerivativeNotionalAmount_2660" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_DerivativesFairValueLineItems_2659" xlink:to="Locator_us-gaap_DerivativeNotionalAmount_2660" order="2.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/DerivativesSummaryOfInterestRateSwapsDetails">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeAssets" xlink:label="Locator_us-gaap_DerivativeAssets_2719" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeAssetStatementOfFinancialPositionExtensibleEnumeration" xlink:label="Locator_us-gaap_DerivativeAssetStatementOfFinancialPositionExtensibleEnumeration_2720" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_DerivativeAssets_2719" xlink:to="Locator_us-gaap_DerivativeAssetStatementOfFinancialPositionExtensibleEnumeration_2720" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_2695" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_CustomerLoansMember" xlink:label="Locator_uscb_CustomerLoansMember_2696" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_2695" xlink:to="Locator_uscb_CustomerLoansMember_2696" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativesFairValueLineItems" xlink:label="Locator_us-gaap_DerivativesFairValueLineItems_2679" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable" xlink:label="Locator_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_2680" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_us-gaap_DerivativesFairValueLineItems_2679" xlink:to="Locator_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_2680" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable" xlink:label="Locator_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_2687" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="Locator_us-gaap_DerivativeInstrumentRiskAxis_2688" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_2687" xlink:to="Locator_us-gaap_DerivativeInstrumentRiskAxis_2688" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="Locator_us-gaap_DerivativeInstrumentRiskAxis_2697" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="Locator_us-gaap_DerivativeContractTypeDomain_2698" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_DerivativeInstrumentRiskAxis_2697" xlink:to="Locator_us-gaap_DerivativeContractTypeDomain_2698" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="Locator_us-gaap_DerivativeContractTypeDomain_2699" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestRateSwapMember" xlink:label="Locator_us-gaap_InterestRateSwapMember_2700" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_DerivativeContractTypeDomain_2699" xlink:to="Locator_us-gaap_InterestRateSwapMember_2700" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable" xlink:label="Locator_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_2689" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationAxis" xlink:label="Locator_us-gaap_HedgingDesignationAxis_2690" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_2689" xlink:to="Locator_us-gaap_HedgingDesignationAxis_2690" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationAxis" xlink:label="Locator_us-gaap_HedgingDesignationAxis_2701" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationDomain" xlink:label="Locator_us-gaap_HedgingDesignationDomain_2702" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_HedgingDesignationAxis_2701" xlink:to="Locator_us-gaap_HedgingDesignationDomain_2702" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationAxis" xlink:label="Locator_us-gaap_HedgingDesignationAxis_2727" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationDomain" xlink:label="Locator_us-gaap_HedgingDesignationDomain_2728" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_us-gaap_HedgingDesignationAxis_2727" xlink:to="Locator_us-gaap_HedgingDesignationDomain_2728" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HedgingDesignationDomain" xlink:label="Locator_us-gaap_HedgingDesignationDomain_2703" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NondesignatedMember" xlink:label="Locator_us-gaap_NondesignatedMember_2704" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_HedgingDesignationDomain_2703" xlink:to="Locator_us-gaap_NondesignatedMember_2704" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable" xlink:label="Locator_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_2691" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationAxis" xlink:label="Locator_us-gaap_BalanceSheetLocationAxis_2692" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_2691" xlink:to="Locator_us-gaap_BalanceSheetLocationAxis_2692" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationAxis" xlink:label="Locator_us-gaap_BalanceSheetLocationAxis_2705" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationDomain" xlink:label="Locator_us-gaap_BalanceSheetLocationDomain_2706" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_BalanceSheetLocationAxis_2705" xlink:to="Locator_us-gaap_BalanceSheetLocationDomain_2706" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationAxis" xlink:label="Locator_us-gaap_BalanceSheetLocationAxis_2725" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationDomain" xlink:label="Locator_us-gaap_BalanceSheetLocationDomain_2726" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_us-gaap_BalanceSheetLocationAxis_2725" xlink:to="Locator_us-gaap_BalanceSheetLocationDomain_2726" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationDomain" xlink:label="Locator_us-gaap_BalanceSheetLocationDomain_2707" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAssetsMember" xlink:label="Locator_us-gaap_OtherAssetsMember_2708" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_BalanceSheetLocationDomain_2707" xlink:to="Locator_us-gaap_OtherAssetsMember_2708" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationDomain" xlink:label="Locator_us-gaap_BalanceSheetLocationDomain_2709" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherLiabilitiesMember" xlink:label="Locator_us-gaap_OtherLiabilitiesMember_2710" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_BalanceSheetLocationDomain_2709" xlink:to="Locator_us-gaap_OtherLiabilitiesMember_2710" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable" xlink:label="Locator_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_2693" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="Locator_us-gaap_FinancialInstrumentAxis_2694" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_FairValuesDerivativesBalanceSheetLocationByDerivativeContractTypeByHedgingDesignationTable_2693" xlink:to="Locator_us-gaap_FinancialInstrumentAxis_2694" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="Locator_us-gaap_FinancialInstrumentAxis_2711" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_2712" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_FinancialInstrumentAxis_2711" xlink:to="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_2712" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativesFairValueLineItems" xlink:label="Locator_us-gaap_DerivativesFairValueLineItems_2713" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeNotionalAmount" xlink:label="Locator_us-gaap_DerivativeNotionalAmount_2714" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_DerivativesFairValueLineItems_2713" xlink:to="Locator_us-gaap_DerivativeNotionalAmount_2714" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativesFairValueLineItems" xlink:label="Locator_us-gaap_DerivativesFairValueLineItems_2715" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeLiabilityCollateralRightToReclaimCashOffset" xlink:label="Locator_us-gaap_DerivativeLiabilityCollateralRightToReclaimCashOffset_2716" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_DerivativesFairValueLineItems_2715" xlink:to="Locator_us-gaap_DerivativeLiabilityCollateralRightToReclaimCashOffset_2716" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativesFairValueLineItems" xlink:label="Locator_us-gaap_DerivativesFairValueLineItems_2717" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeAssets" xlink:label="Locator_us-gaap_DerivativeAssets_2718" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_DerivativesFairValueLineItems_2717" xlink:to="Locator_us-gaap_DerivativeAssets_2718" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativesFairValueLineItems" xlink:label="Locator_us-gaap_DerivativesFairValueLineItems_2721" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeLiabilities" xlink:label="Locator_us-gaap_DerivativeLiabilities_2722" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_DerivativesFairValueLineItems_2721" xlink:to="Locator_us-gaap_DerivativeLiabilities_2722" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeLiabilities" xlink:label="Locator_us-gaap_DerivativeLiabilities_2723" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeLiabilityStatementOfFinancialPositionExtensibleEnumeration" xlink:label="Locator_us-gaap_DerivativeLiabilityStatementOfFinancialPositionExtensibleEnumeration_2724" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_DerivativeLiabilities_2723" xlink:to="Locator_us-gaap_DerivativeLiabilityStatementOfFinancialPositionExtensibleEnumeration_2724" order="1.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/FairValueMeasurementsNarrativeDetails">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="Locator_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_2765" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel3Member" xlink:label="Locator_us-gaap_FairValueInputsLevel3Member_2766" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_2765" xlink:to="Locator_us-gaap_FairValueInputsLevel3Member_2766" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:label="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_2767" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LoansAndLeasesReceivableNetReportedAmount" xlink:label="Locator_us-gaap_LoansAndLeasesReceivableNetReportedAmount_2768" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_2767" xlink:to="Locator_us-gaap_LoansAndLeasesReceivableNetReportedAmount_2768" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:label="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_2769" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableAllowanceForCreditLossesWriteOffs" xlink:label="Locator_us-gaap_FinancingReceivableAllowanceForCreditLossesWriteOffs_2770" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_2769" xlink:to="Locator_us-gaap_FinancingReceivableAllowanceForCreditLossesWriteOffs_2770" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:label="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_2771" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:label="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_2772" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_2771" xlink:to="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_2772" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:label="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_2773" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="Locator_us-gaap_FairValueByFairValueHierarchyLevelAxis_2774" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_2773" xlink:to="Locator_us-gaap_FairValueByFairValueHierarchyLevelAxis_2774" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="Locator_us-gaap_FairValueByFairValueHierarchyLevelAxis_2775" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="Locator_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_2776" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_FairValueByFairValueHierarchyLevelAxis_2775" xlink:to="Locator_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_2776" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="Locator_us-gaap_FairValueByFairValueHierarchyLevelAxis_2777" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="Locator_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_2778" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_us-gaap_FairValueByFairValueHierarchyLevelAxis_2777" xlink:to="Locator_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_2778" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:label="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_2779" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByAssetClassAxis" xlink:label="Locator_us-gaap_FairValueByAssetClassAxis_2780" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_2779" xlink:to="Locator_us-gaap_FairValueByAssetClassAxis_2780" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByAssetClassAxis" xlink:label="Locator_us-gaap_FairValueByAssetClassAxis_2781" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="Locator_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_2782" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_FairValueByAssetClassAxis_2781" xlink:to="Locator_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_2782" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByAssetClassAxis" xlink:label="Locator_us-gaap_FairValueByAssetClassAxis_2783" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="Locator_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_2784" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_us-gaap_FairValueByAssetClassAxis_2783" xlink:to="Locator_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_2784" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="Locator_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_2785" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_ImpairedLoansMember" xlink:label="Locator_uscb_ImpairedLoansMember_2786" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_2785" xlink:to="Locator_uscb_ImpairedLoansMember_2786" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:label="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_2787" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByMeasurementFrequencyAxis" xlink:label="Locator_us-gaap_FairValueByMeasurementFrequencyAxis_2788" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_2787" xlink:to="Locator_us-gaap_FairValueByMeasurementFrequencyAxis_2788" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByMeasurementFrequencyAxis" xlink:label="Locator_us-gaap_FairValueByMeasurementFrequencyAxis_2789" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementFrequencyDomain" xlink:label="Locator_us-gaap_FairValueMeasurementFrequencyDomain_2790" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_FairValueByMeasurementFrequencyAxis_2789" xlink:to="Locator_us-gaap_FairValueMeasurementFrequencyDomain_2790" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByMeasurementFrequencyAxis" xlink:label="Locator_us-gaap_FairValueByMeasurementFrequencyAxis_2791" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementFrequencyDomain" xlink:label="Locator_us-gaap_FairValueMeasurementFrequencyDomain_2792" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_us-gaap_FairValueByMeasurementFrequencyAxis_2791" xlink:to="Locator_us-gaap_FairValueMeasurementFrequencyDomain_2792" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementFrequencyDomain" xlink:label="Locator_us-gaap_FairValueMeasurementFrequencyDomain_2793" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsNonrecurringMember" xlink:label="Locator_us-gaap_FairValueMeasurementsNonrecurringMember_2794" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FairValueMeasurementFrequencyDomain_2793" xlink:to="Locator_us-gaap_FairValueMeasurementsNonrecurringMember_2794" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:label="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_2795" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsFairValueDisclosure" xlink:label="Locator_us-gaap_AssetsFairValueDisclosure_2796" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_2795" xlink:to="Locator_us-gaap_AssetsFairValueDisclosure_2796" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:label="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_2797" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialLiabilitiesFairValueDisclosure" xlink:label="Locator_us-gaap_FinancialLiabilitiesFairValueDisclosure_2798" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_2797" xlink:to="Locator_us-gaap_FinancialLiabilitiesFairValueDisclosure_2798" order="4.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/LoansNarrativeDetails">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CollateralDomain" xlink:label="Locator_us-gaap_CollateralDomain_2879" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommercialRealEstateMember" xlink:label="Locator_us-gaap_CommercialRealEstateMember_2880" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_CollateralDomain_2879" xlink:to="Locator_us-gaap_CommercialRealEstateMember_2880" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CollateralDomain" xlink:label="Locator_us-gaap_CollateralDomain_2881" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResidentialRealEstateMember" xlink:label="Locator_us-gaap_ResidentialRealEstateMember_2882" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_CollateralDomain_2881" xlink:to="Locator_us-gaap_ResidentialRealEstateMember_2882" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsNotesAndLoansReceivableLineItems" xlink:label="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_2909" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NotesReceivableGross" xlink:label="Locator_us-gaap_NotesReceivableGross_2910" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_2909" xlink:to="Locator_us-gaap_NotesReceivableGross_2910" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsNotesAndLoansReceivableLineItems" xlink:label="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_2911" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MortgageLoansInProcessOfForeclosureAmount" xlink:label="Locator_us-gaap_MortgageLoansInProcessOfForeclosureAmount_2912" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_2911" xlink:to="Locator_us-gaap_MortgageLoansInProcessOfForeclosureAmount_2912" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsNotesAndLoansReceivableLineItems" xlink:label="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_2913" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentFaceAmount" xlink:label="Locator_us-gaap_DebtInstrumentFaceAmount_2914" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_2913" xlink:to="Locator_us-gaap_DebtInstrumentFaceAmount_2914" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsNotesAndLoansReceivableLineItems" xlink:label="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_2915" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DeferredLoanFees" xlink:label="Locator_uscb_DeferredLoanFees_2916" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_2915" xlink:to="Locator_uscb_DeferredLoanFees_2916" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsNotesAndLoansReceivableLineItems" xlink:label="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_2917" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentFeeAmount" xlink:label="Locator_us-gaap_DebtInstrumentFeeAmount_2918" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_2917" xlink:to="Locator_us-gaap_DebtInstrumentFeeAmount_2918" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsNotesAndLoansReceivableLineItems" xlink:label="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_2919" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableNonaccrualInterestIncome" xlink:label="Locator_us-gaap_FinancingReceivableNonaccrualInterestIncome_2920" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_2919" xlink:to="Locator_us-gaap_FinancingReceivableNonaccrualInterestIncome_2920" order="6.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsNotesAndLoansReceivableLineItems" xlink:label="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_2921" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestIncomeFinancingReceivableBeforeAllowanceForCreditLoss" xlink:label="Locator_us-gaap_InterestIncomeFinancingReceivableBeforeAllowanceForCreditLoss_2922" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_2921" xlink:to="Locator_us-gaap_InterestIncomeFinancingReceivableBeforeAllowanceForCreditLoss_2922" order="7.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsNotesAndLoansReceivableLineItems" xlink:label="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_2923" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LoansAndLeasesReceivableImpairedTroubledDebtInterestIncome" xlink:label="Locator_us-gaap_LoansAndLeasesReceivableImpairedTroubledDebtInterestIncome_2924" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_2923" xlink:to="Locator_us-gaap_LoansAndLeasesReceivableImpairedTroubledDebtInterestIncome_2924" order="8.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsNotesAndLoansReceivableLineItems" xlink:label="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_2925" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ImpairedFinancingReceivableRelatedAllowance" xlink:label="Locator_us-gaap_ImpairedFinancingReceivableRelatedAllowance_2926" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_2925" xlink:to="Locator_us-gaap_ImpairedFinancingReceivableRelatedAllowance_2926" order="9.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsNotesAndLoansReceivableLineItems" xlink:label="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_2927" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LoansAndLeasesReceivableImpairedCommitmentToLend" xlink:label="Locator_us-gaap_LoansAndLeasesReceivableImpairedCommitmentToLend_2928" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_2927" xlink:to="Locator_us-gaap_LoansAndLeasesReceivableImpairedCommitmentToLend_2928" order="10.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsNotesAndLoansReceivableLineItems" xlink:label="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_2929" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableAllowanceForCreditLossesWriteOffs" xlink:label="Locator_us-gaap_FinancingReceivableAllowanceForCreditLossesWriteOffs_2930" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_2929" xlink:to="Locator_us-gaap_FinancingReceivableAllowanceForCreditLossesWriteOffs_2930" order="11.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsNotesAndLoansReceivableLineItems" xlink:label="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_2931" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_FinancingReceivablesImpairedTroubledDebtRestructuringRelatedAllowanceLoansModifiedDuringPeriod" xlink:label="Locator_uscb_FinancingReceivablesImpairedTroubledDebtRestructuringRelatedAllowanceLoansModifiedDuringPeriod_2932" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_2931" xlink:to="Locator_uscb_FinancingReceivablesImpairedTroubledDebtRestructuringRelatedAllowanceLoansModifiedDuringPeriod_2932" order="12.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsNotesAndLoansReceivableLineItems" xlink:label="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_2933" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableModificationsNumberOfContracts2" xlink:label="Locator_us-gaap_FinancingReceivableModificationsNumberOfContracts2_2934" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_2933" xlink:to="Locator_us-gaap_FinancingReceivableModificationsNumberOfContracts2_2934" order="13.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsNotesAndLoansReceivableLineItems" xlink:label="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_2935" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableModificationsRecordedInvestment" xlink:label="Locator_us-gaap_FinancingReceivableModificationsRecordedInvestment_2936" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_2935" xlink:to="Locator_us-gaap_FinancingReceivableModificationsRecordedInvestment_2936" order="14.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsNotesAndLoansReceivableLineItems" xlink:label="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_2863" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable" xlink:label="Locator_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_2864" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_2863" xlink:to="Locator_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_2864" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable" xlink:label="Locator_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_2869" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CollateralAxis" xlink:label="Locator_us-gaap_CollateralAxis_2870" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_2869" xlink:to="Locator_us-gaap_CollateralAxis_2870" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CollateralAxis" xlink:label="Locator_us-gaap_CollateralAxis_2883" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CollateralDomain" xlink:label="Locator_us-gaap_CollateralDomain_2884" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_CollateralAxis_2883" xlink:to="Locator_us-gaap_CollateralDomain_2884" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CollateralAxis" xlink:label="Locator_us-gaap_CollateralAxis_2943" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CollateralDomain" xlink:label="Locator_us-gaap_CollateralDomain_2944" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_us-gaap_CollateralAxis_2943" xlink:to="Locator_us-gaap_CollateralDomain_2944" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable" xlink:label="Locator_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_2871" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentAxis" xlink:label="Locator_us-gaap_DebtInstrumentAxis_2872" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_2871" xlink:to="Locator_us-gaap_DebtInstrumentAxis_2872" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentAxis" xlink:label="Locator_us-gaap_DebtInstrumentAxis_2885" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="Locator_us-gaap_DebtInstrumentNameDomain_2886" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_DebtInstrumentAxis_2885" xlink:to="Locator_us-gaap_DebtInstrumentNameDomain_2886" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentAxis" xlink:label="Locator_us-gaap_DebtInstrumentAxis_2941" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="Locator_us-gaap_DebtInstrumentNameDomain_2942" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_us-gaap_DebtInstrumentAxis_2941" xlink:to="Locator_us-gaap_DebtInstrumentNameDomain_2942" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="Locator_us-gaap_DebtInstrumentNameDomain_2887" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_PaycheckProtectionProgramMember" xlink:label="Locator_uscb_PaycheckProtectionProgramMember_2888" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_DebtInstrumentNameDomain_2887" xlink:to="Locator_uscb_PaycheckProtectionProgramMember_2888" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable" xlink:label="Locator_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_2873" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LoanRestructuringModificationNameAxis" xlink:label="Locator_us-gaap_LoanRestructuringModificationNameAxis_2874" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_2873" xlink:to="Locator_us-gaap_LoanRestructuringModificationNameAxis_2874" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LoanRestructuringModificationNameAxis" xlink:label="Locator_us-gaap_LoanRestructuringModificationNameAxis_2893" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LoanRestructuringModificationNameDomain" xlink:label="Locator_us-gaap_LoanRestructuringModificationNameDomain_2894" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_LoanRestructuringModificationNameAxis_2893" xlink:to="Locator_us-gaap_LoanRestructuringModificationNameDomain_2894" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LoanRestructuringModificationNameAxis" xlink:label="Locator_us-gaap_LoanRestructuringModificationNameAxis_2937" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LoanRestructuringModificationNameDomain" xlink:label="Locator_us-gaap_LoanRestructuringModificationNameDomain_2938" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_us-gaap_LoanRestructuringModificationNameAxis_2937" xlink:to="Locator_us-gaap_LoanRestructuringModificationNameDomain_2938" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LoanRestructuringModificationNameDomain" xlink:label="Locator_us-gaap_LoanRestructuringModificationNameDomain_2895" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_CaresActModificationsMember" xlink:label="Locator_uscb_CaresActModificationsMember_2896" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_LoanRestructuringModificationNameDomain_2895" xlink:to="Locator_uscb_CaresActModificationsMember_2896" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LoanRestructuringModificationNameDomain" xlink:label="Locator_us-gaap_LoanRestructuringModificationNameDomain_2897" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_TdrLoansMember" xlink:label="Locator_uscb_TdrLoansMember_2898" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_LoanRestructuringModificationNameDomain_2897" xlink:to="Locator_uscb_TdrLoansMember_2898" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable" xlink:label="Locator_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_2875" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablesPeriodPastDueAxis" xlink:label="Locator_us-gaap_FinancingReceivablesPeriodPastDueAxis_2876" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_2875" xlink:to="Locator_us-gaap_FinancingReceivablesPeriodPastDueAxis_2876" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablesPeriodPastDueAxis" xlink:label="Locator_us-gaap_FinancingReceivablesPeriodPastDueAxis_2899" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablesPeriodPastDueDomain" xlink:label="Locator_us-gaap_FinancingReceivablesPeriodPastDueDomain_2900" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_FinancingReceivablesPeriodPastDueAxis_2899" xlink:to="Locator_us-gaap_FinancingReceivablesPeriodPastDueDomain_2900" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablesPeriodPastDueDomain" xlink:label="Locator_us-gaap_FinancingReceivablesPeriodPastDueDomain_2901" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_FinancialAssetNonAccrualMember" xlink:label="Locator_uscb_FinancialAssetNonAccrualMember_2902" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablesPeriodPastDueDomain_2901" xlink:to="Locator_uscb_FinancialAssetNonAccrualMember_2902" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablesPeriodPastDueDomain" xlink:label="Locator_us-gaap_FinancingReceivablesPeriodPastDueDomain_2903" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialAssetPastDueMember" xlink:label="Locator_us-gaap_FinancialAssetPastDueMember_2904" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablesPeriodPastDueDomain_2903" xlink:to="Locator_us-gaap_FinancialAssetPastDueMember_2904" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable" xlink:label="Locator_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_2877" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PledgingPurposeAxis" xlink:label="Locator_us-gaap_PledgingPurposeAxis_2878" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_2877" xlink:to="Locator_us-gaap_PledgingPurposeAxis_2878" order="6.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PledgingPurposeAxis" xlink:label="Locator_us-gaap_PledgingPurposeAxis_2905" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PledgingPurposeDomain" xlink:label="Locator_us-gaap_PledgingPurposeDomain_2906" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_PledgingPurposeAxis_2905" xlink:to="Locator_us-gaap_PledgingPurposeDomain_2906" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PledgingPurposeDomain" xlink:label="Locator_us-gaap_PledgingPurposeDomain_2907" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FederalHomeLoanBankAdvancesMember" xlink:label="Locator_us-gaap_FederalHomeLoanBankAdvancesMember_2908" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_PledgingPurposeDomain_2907" xlink:to="Locator_us-gaap_FederalHomeLoanBankAdvancesMember_2908" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable" xlink:label="Locator_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_2867" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentAxis" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentAxis_2868" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_2867" xlink:to="Locator_us-gaap_FinancingReceivablePortfolioSegmentAxis_2868" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentAxis" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentAxis_2889" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_2890" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentAxis_2889" xlink:to="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_2890" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentAxis" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentAxis_2939" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_2940" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentAxis_2939" xlink:to="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_2940" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_2891" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_CommercialAndIndustrialMember" xlink:label="Locator_uscb_CommercialAndIndustrialMember_2892" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_2891" xlink:to="Locator_uscb_CommercialAndIndustrialMember_2892" order="1.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/LoansSummaryOfLoansHeldForInvestmentDetails">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsNotesAndLoansReceivableLineItems" xlink:label="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_3001" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable" xlink:label="Locator_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_3002" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_3001" xlink:to="Locator_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_3002" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable" xlink:label="Locator_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_3013" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentAxis" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentAxis_3014" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_3013" xlink:to="Locator_us-gaap_FinancingReceivablePortfolioSegmentAxis_3014" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentAxis" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentAxis_3019" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3020" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentAxis_3019" xlink:to="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3020" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3027" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_ForeignBanksMember" xlink:label="Locator_uscb_ForeignBanksMember_3028" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3027" xlink:to="Locator_uscb_ForeignBanksMember_3028" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3021" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResidentialPortfolioSegmentMember" xlink:label="Locator_us-gaap_ResidentialPortfolioSegmentMember_3022" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3021" xlink:to="Locator_us-gaap_ResidentialPortfolioSegmentMember_3022" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3023" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommercialRealEstatePortfolioSegmentMember" xlink:label="Locator_us-gaap_CommercialRealEstatePortfolioSegmentMember_3024" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3023" xlink:to="Locator_us-gaap_CommercialRealEstatePortfolioSegmentMember_3024" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3025" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_CommercialAndIndustrialMember" xlink:label="Locator_uscb_CommercialAndIndustrialMember_3026" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3025" xlink:to="Locator_uscb_CommercialAndIndustrialMember_3026" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3029" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_ConsumerAndOtherMember" xlink:label="Locator_uscb_ConsumerAndOtherMember_3030" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3029" xlink:to="Locator_uscb_ConsumerAndOtherMember_3030" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable" xlink:label="Locator_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_3015" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis" xlink:label="Locator_us-gaap_ConcentrationRiskByBenchmarkAxis_3016" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_3015" xlink:to="Locator_us-gaap_ConcentrationRiskByBenchmarkAxis_3016" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis" xlink:label="Locator_us-gaap_ConcentrationRiskByBenchmarkAxis_3031" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskBenchmarkDomain" xlink:label="Locator_us-gaap_ConcentrationRiskBenchmarkDomain_3032" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_ConcentrationRiskByBenchmarkAxis_3031" xlink:to="Locator_us-gaap_ConcentrationRiskBenchmarkDomain_3032" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskBenchmarkDomain" xlink:label="Locator_us-gaap_ConcentrationRiskBenchmarkDomain_3033" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsReceivableMember" xlink:label="Locator_us-gaap_AccountsReceivableMember_3034" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ConcentrationRiskBenchmarkDomain_3033" xlink:to="Locator_us-gaap_AccountsReceivableMember_3034" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable" xlink:label="Locator_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_3017" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskByTypeAxis" xlink:label="Locator_us-gaap_ConcentrationRiskByTypeAxis_3018" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_ScheduleOfAccountsNotesLoansAndFinancingReceivableTable_3017" xlink:to="Locator_us-gaap_ConcentrationRiskByTypeAxis_3018" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskByTypeAxis" xlink:label="Locator_us-gaap_ConcentrationRiskByTypeAxis_3035" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskTypeDomain" xlink:label="Locator_us-gaap_ConcentrationRiskTypeDomain_3036" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_ConcentrationRiskByTypeAxis_3035" xlink:to="Locator_us-gaap_ConcentrationRiskTypeDomain_3036" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskTypeDomain" xlink:label="Locator_us-gaap_ConcentrationRiskTypeDomain_3037" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CreditConcentrationRiskMember" xlink:label="Locator_us-gaap_CreditConcentrationRiskMember_3038" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ConcentrationRiskTypeDomain_3037" xlink:to="Locator_us-gaap_CreditConcentrationRiskMember_3038" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsNotesAndLoansReceivableLineItems" xlink:label="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_3039" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LoansAndLeasesReceivableGrossCarryingAmount" xlink:label="Locator_us-gaap_LoansAndLeasesReceivableGrossCarryingAmount_3040" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_3039" xlink:to="Locator_us-gaap_LoansAndLeasesReceivableGrossCarryingAmount_3040" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsNotesAndLoansReceivableLineItems" xlink:label="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_3041" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LoansAndLeasesReceivableDeferredIncome" xlink:label="Locator_us-gaap_LoansAndLeasesReceivableDeferredIncome_3042" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_3041" xlink:to="Locator_us-gaap_LoansAndLeasesReceivableDeferredIncome_3042" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsNotesAndLoansReceivableLineItems" xlink:label="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_3043" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LoansAndLeasesReceivableNetOfDeferredIncome" xlink:label="Locator_us-gaap_LoansAndLeasesReceivableNetOfDeferredIncome_3044" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_3043" xlink:to="Locator_us-gaap_LoansAndLeasesReceivableNetOfDeferredIncome_3044" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsNotesAndLoansReceivableLineItems" xlink:label="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_3045" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LoansAndLeasesReceivableAllowance" xlink:label="Locator_us-gaap_LoansAndLeasesReceivableAllowance_3046" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_3045" xlink:to="Locator_us-gaap_LoansAndLeasesReceivableAllowance_3046" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsNotesAndLoansReceivableLineItems" xlink:label="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_3047" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LoansAndLeasesReceivableNetReportedAmount" xlink:label="Locator_us-gaap_LoansAndLeasesReceivableNetReportedAmount_3048" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_3047" xlink:to="Locator_us-gaap_LoansAndLeasesReceivableNetReportedAmount_3048" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsNotesAndLoansReceivableLineItems" xlink:label="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_3049" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_PercentOfTotalLoans" xlink:label="Locator_uscb_PercentOfTotalLoans_3050" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_AccountsNotesAndLoansReceivableLineItems_3049" xlink:to="Locator_uscb_PercentOfTotalLoans_3050" order="6.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/LoansAllowanceForCreditLossesDetails">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentAxis" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentAxis_3113" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3114" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentAxis_3113" xlink:to="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3114" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3115" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_ForeignBanksMember" xlink:label="Locator_uscb_ForeignBanksMember_3116" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3115" xlink:to="Locator_uscb_ForeignBanksMember_3116" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3119" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResidentialPortfolioSegmentMember" xlink:label="Locator_us-gaap_ResidentialPortfolioSegmentMember_3120" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3119" xlink:to="Locator_us-gaap_ResidentialPortfolioSegmentMember_3120" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3121" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommercialRealEstatePortfolioSegmentMember" xlink:label="Locator_us-gaap_CommercialRealEstatePortfolioSegmentMember_3122" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3121" xlink:to="Locator_us-gaap_CommercialRealEstatePortfolioSegmentMember_3122" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3123" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_CommercialAndIndustrialMember" xlink:label="Locator_uscb_CommercialAndIndustrialMember_3124" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3123" xlink:to="Locator_uscb_CommercialAndIndustrialMember_3124" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3117" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_ConsumerAndOtherMember" xlink:label="Locator_uscb_ConsumerAndOtherMember_3118" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3117" xlink:to="Locator_uscb_ConsumerAndOtherMember_3118" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableAllowanceForCreditLossesLineItems" xlink:label="Locator_us-gaap_FinancingReceivableAllowanceForCreditLossesLineItems_3125" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfFinancingReceivableAllowanceForCreditLossesTable" xlink:label="Locator_us-gaap_ScheduleOfFinancingReceivableAllowanceForCreditLossesTable_3126" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_us-gaap_FinancingReceivableAllowanceForCreditLossesLineItems_3125" xlink:to="Locator_us-gaap_ScheduleOfFinancingReceivableAllowanceForCreditLossesTable_3126" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfFinancingReceivableAllowanceForCreditLossesTable" xlink:label="Locator_us-gaap_ScheduleOfFinancingReceivableAllowanceForCreditLossesTable_3127" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentAxis" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentAxis_3128" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_ScheduleOfFinancingReceivableAllowanceForCreditLossesTable_3127" xlink:to="Locator_us-gaap_FinancingReceivablePortfolioSegmentAxis_3128" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableAllowanceForCreditLossesLineItems" xlink:label="Locator_us-gaap_FinancingReceivableAllowanceForCreditLossesLineItems_3129" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableAllowanceForCreditLosses" xlink:label="Locator_us-gaap_FinancingReceivableAllowanceForCreditLosses_3130" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableAllowanceForCreditLossesLineItems_3129" xlink:to="Locator_us-gaap_FinancingReceivableAllowanceForCreditLosses_3130" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableAllowanceForCreditLossesLineItems" xlink:label="Locator_us-gaap_FinancingReceivableAllowanceForCreditLossesLineItems_3131" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProvisionForLoanLeaseAndOtherLosses" xlink:label="Locator_us-gaap_ProvisionForLoanLeaseAndOtherLosses_3132" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableAllowanceForCreditLossesLineItems_3131" xlink:to="Locator_us-gaap_ProvisionForLoanLeaseAndOtherLosses_3132" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableAllowanceForCreditLossesLineItems" xlink:label="Locator_us-gaap_FinancingReceivableAllowanceForCreditLossesLineItems_3133" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableAllowanceForCreditLossesRecovery" xlink:label="Locator_us-gaap_FinancingReceivableAllowanceForCreditLossesRecovery_3134" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableAllowanceForCreditLossesLineItems_3133" xlink:to="Locator_us-gaap_FinancingReceivableAllowanceForCreditLossesRecovery_3134" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableAllowanceForCreditLossesLineItems" xlink:label="Locator_us-gaap_FinancingReceivableAllowanceForCreditLossesLineItems_3135" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableAllowanceForCreditLossesWriteOffs" xlink:label="Locator_us-gaap_FinancingReceivableAllowanceForCreditLossesWriteOffs_3136" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableAllowanceForCreditLossesLineItems_3135" xlink:to="Locator_us-gaap_FinancingReceivableAllowanceForCreditLossesWriteOffs_3136" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableAllowanceForCreditLossesLineItems" xlink:label="Locator_us-gaap_FinancingReceivableAllowanceForCreditLossesLineItems_3137" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_FinancingReceivableAllowanceForCreditLossAbstract" xlink:label="Locator_uscb_FinancingReceivableAllowanceForCreditLossAbstract_3138" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableAllowanceForCreditLossesLineItems_3137" xlink:to="Locator_uscb_FinancingReceivableAllowanceForCreditLossAbstract_3138" order="6.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_FinancingReceivableAllowanceForCreditLossAbstract" xlink:label="Locator_uscb_FinancingReceivableAllowanceForCreditLossAbstract_3139" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableAllowanceForCreditLossesIndividuallyEvaluatedForImpairment1" xlink:label="Locator_us-gaap_FinancingReceivableAllowanceForCreditLossesIndividuallyEvaluatedForImpairment1_3140" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_FinancingReceivableAllowanceForCreditLossAbstract_3139" xlink:to="Locator_us-gaap_FinancingReceivableAllowanceForCreditLossesIndividuallyEvaluatedForImpairment1_3140" order="1.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_FinancingReceivableAllowanceForCreditLossAbstract" xlink:label="Locator_uscb_FinancingReceivableAllowanceForCreditLossAbstract_3141" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableAllowanceForCreditLossesCollectivelyEvaluatedForImpairment" xlink:label="Locator_us-gaap_FinancingReceivableAllowanceForCreditLossesCollectivelyEvaluatedForImpairment_3142" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_FinancingReceivableAllowanceForCreditLossAbstract_3141" xlink:to="Locator_us-gaap_FinancingReceivableAllowanceForCreditLossesCollectivelyEvaluatedForImpairment_3142" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableAllowanceForCreditLossesLineItems" xlink:label="Locator_us-gaap_FinancingReceivableAllowanceForCreditLossesLineItems_3143" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_FinancingReceivableLoansAbstract" xlink:label="Locator_uscb_FinancingReceivableLoansAbstract_3144" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableAllowanceForCreditLossesLineItems_3143" xlink:to="Locator_uscb_FinancingReceivableLoansAbstract_3144" order="7.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_FinancingReceivableLoansAbstract" xlink:label="Locator_uscb_FinancingReceivableLoansAbstract_3145" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableIndividuallyEvaluatedForImpairment" xlink:label="Locator_us-gaap_FinancingReceivableIndividuallyEvaluatedForImpairment_3146" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_FinancingReceivableLoansAbstract_3145" xlink:to="Locator_us-gaap_FinancingReceivableIndividuallyEvaluatedForImpairment_3146" order="1.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_FinancingReceivableLoansAbstract" xlink:label="Locator_uscb_FinancingReceivableLoansAbstract_3147" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableCollectivelyEvaluatedForImpairment" xlink:label="Locator_us-gaap_FinancingReceivableCollectivelyEvaluatedForImpairment_3148" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_FinancingReceivableLoansAbstract_3147" xlink:to="Locator_us-gaap_FinancingReceivableCollectivelyEvaluatedForImpairment_3148" order="2.0" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_FinancingReceivableLoansAbstract" xlink:label="Locator_uscb_FinancingReceivableLoansAbstract_3149" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NotesReceivableGross" xlink:label="Locator_us-gaap_NotesReceivableGross_3150" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_uscb_FinancingReceivableLoansAbstract_3149" xlink:to="Locator_us-gaap_NotesReceivableGross_3150" order="3.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/LoansLoanCreditExposuresDetails">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentAxis" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentAxis_3181" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3182" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentAxis_3181" xlink:to="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3182" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3189" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_ForeignBanksMember" xlink:label="Locator_uscb_ForeignBanksMember_3190" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3189" xlink:to="Locator_uscb_ForeignBanksMember_3190" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3183" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResidentialPortfolioSegmentMember" xlink:label="Locator_us-gaap_ResidentialPortfolioSegmentMember_3184" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3183" xlink:to="Locator_us-gaap_ResidentialPortfolioSegmentMember_3184" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3185" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommercialRealEstatePortfolioSegmentMember" xlink:label="Locator_us-gaap_CommercialRealEstatePortfolioSegmentMember_3186" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3185" xlink:to="Locator_us-gaap_CommercialRealEstatePortfolioSegmentMember_3186" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3187" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_CommercialAndIndustrialMember" xlink:label="Locator_uscb_CommercialAndIndustrialMember_3188" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3187" xlink:to="Locator_uscb_CommercialAndIndustrialMember_3188" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3191" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_ConsumerAndOtherMember" xlink:label="Locator_uscb_ConsumerAndOtherMember_3192" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3191" xlink:to="Locator_uscb_ConsumerAndOtherMember_3192" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestmentLineItems" xlink:label="Locator_us-gaap_FinancingReceivableRecordedInvestmentLineItems_3171" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfFinancingReceivableRecordedInvestmentCreditQualityIndicatorTable" xlink:label="Locator_us-gaap_ScheduleOfFinancingReceivableRecordedInvestmentCreditQualityIndicatorTable_3172" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_us-gaap_FinancingReceivableRecordedInvestmentLineItems_3171" xlink:to="Locator_us-gaap_ScheduleOfFinancingReceivableRecordedInvestmentCreditQualityIndicatorTable_3172" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfFinancingReceivableRecordedInvestmentCreditQualityIndicatorTable" xlink:label="Locator_us-gaap_ScheduleOfFinancingReceivableRecordedInvestmentCreditQualityIndicatorTable_3175" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InternalCreditAssessmentAxis" xlink:label="Locator_us-gaap_InternalCreditAssessmentAxis_3176" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_ScheduleOfFinancingReceivableRecordedInvestmentCreditQualityIndicatorTable_3175" xlink:to="Locator_us-gaap_InternalCreditAssessmentAxis_3176" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InternalCreditAssessmentAxis" xlink:label="Locator_us-gaap_InternalCreditAssessmentAxis_3215" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InternalCreditAssessmentDomain" xlink:label="Locator_us-gaap_InternalCreditAssessmentDomain_3216" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_InternalCreditAssessmentAxis_3215" xlink:to="Locator_us-gaap_InternalCreditAssessmentDomain_3216" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InternalCreditAssessmentAxis" xlink:label="Locator_us-gaap_InternalCreditAssessmentAxis_3227" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InternalCreditAssessmentDomain" xlink:label="Locator_us-gaap_InternalCreditAssessmentDomain_3228" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_us-gaap_InternalCreditAssessmentAxis_3227" xlink:to="Locator_us-gaap_InternalCreditAssessmentDomain_3228" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InternalCreditAssessmentDomain" xlink:label="Locator_us-gaap_InternalCreditAssessmentDomain_3217" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PassMember" xlink:label="Locator_us-gaap_PassMember_3218" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_InternalCreditAssessmentDomain_3217" xlink:to="Locator_us-gaap_PassMember_3218" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InternalCreditAssessmentDomain" xlink:label="Locator_us-gaap_InternalCreditAssessmentDomain_3219" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SpecialMentionMember" xlink:label="Locator_us-gaap_SpecialMentionMember_3220" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_InternalCreditAssessmentDomain_3219" xlink:to="Locator_us-gaap_SpecialMentionMember_3220" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InternalCreditAssessmentDomain" xlink:label="Locator_us-gaap_InternalCreditAssessmentDomain_3221" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubstandardMember" xlink:label="Locator_us-gaap_SubstandardMember_3222" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_InternalCreditAssessmentDomain_3221" xlink:to="Locator_us-gaap_SubstandardMember_3222" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InternalCreditAssessmentDomain" xlink:label="Locator_us-gaap_InternalCreditAssessmentDomain_3223" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DoubtfulMember" xlink:label="Locator_us-gaap_DoubtfulMember_3224" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_InternalCreditAssessmentDomain_3223" xlink:to="Locator_us-gaap_DoubtfulMember_3224" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfFinancingReceivableRecordedInvestmentCreditQualityIndicatorTable" xlink:label="Locator_us-gaap_ScheduleOfFinancingReceivableRecordedInvestmentCreditQualityIndicatorTable_3177" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentAxis" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentAxis_3178" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_ScheduleOfFinancingReceivableRecordedInvestmentCreditQualityIndicatorTable_3177" xlink:to="Locator_us-gaap_FinancingReceivablePortfolioSegmentAxis_3178" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfFinancingReceivableRecordedInvestmentCreditQualityIndicatorTable" xlink:label="Locator_us-gaap_ScheduleOfFinancingReceivableRecordedInvestmentCreditQualityIndicatorTable_3179" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis" xlink:label="Locator_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_3180" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_ScheduleOfFinancingReceivableRecordedInvestmentCreditQualityIndicatorTable_3179" xlink:to="Locator_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_3180" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis" xlink:label="Locator_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_3193" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain" xlink:label="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3194" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_3193" xlink:to="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3194" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis" xlink:label="Locator_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_3229" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain" xlink:label="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3230" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_3229" xlink:to="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3230" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain" xlink:label="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3195" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_HomeEquityLineOfCreditAndOtherMember" xlink:label="Locator_uscb_HomeEquityLineOfCreditAndOtherMember_3196" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3195" xlink:to="Locator_uscb_HomeEquityLineOfCreditAndOtherMember_3196" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain" xlink:label="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3197" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_OneToFourFamilyResidentialMember" xlink:label="Locator_uscb_OneToFourFamilyResidentialMember_3198" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3197" xlink:to="Locator_uscb_OneToFourFamilyResidentialMember_3198" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain" xlink:label="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3199" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_CondoResidentialMember" xlink:label="Locator_uscb_CondoResidentialMember_3200" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3199" xlink:to="Locator_uscb_CondoResidentialMember_3200" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain" xlink:label="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3201" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_LandAndConstructionMember" xlink:label="Locator_uscb_LandAndConstructionMember_3202" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3201" xlink:to="Locator_uscb_LandAndConstructionMember_3202" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain" xlink:label="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3203" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_MultifamilyResidentialMember" xlink:label="Locator_uscb_MultifamilyResidentialMember_3204" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3203" xlink:to="Locator_uscb_MultifamilyResidentialMember_3204" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain" xlink:label="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3205" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_CondoCommercialMember" xlink:label="Locator_uscb_CondoCommercialMember_3206" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3205" xlink:to="Locator_uscb_CondoCommercialMember_3206" order="6.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain" xlink:label="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3207" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_CommercialPropertyMember" xlink:label="Locator_uscb_CommercialPropertyMember_3208" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3207" xlink:to="Locator_uscb_CommercialPropertyMember_3208" order="7.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain" xlink:label="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3209" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeaseholdImprovementsMember" xlink:label="Locator_us-gaap_LeaseholdImprovementsMember_3210" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3209" xlink:to="Locator_us-gaap_LeaseholdImprovementsMember_3210" order="8.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain" xlink:label="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3211" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_SecuredMember" xlink:label="Locator_uscb_SecuredMember_3212" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3211" xlink:to="Locator_uscb_SecuredMember_3212" order="9.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain" xlink:label="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3213" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_UnsecuredMember" xlink:label="Locator_uscb_UnsecuredMember_3214" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3213" xlink:to="Locator_uscb_UnsecuredMember_3214" order="10.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestmentLineItems" xlink:label="Locator_us-gaap_FinancingReceivableRecordedInvestmentLineItems_3225" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NotesReceivableGross" xlink:label="Locator_us-gaap_NotesReceivableGross_3226" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableRecordedInvestmentLineItems_3225" xlink:to="Locator_us-gaap_NotesReceivableGross_3226" order="1.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/LoansAgingAnalysisOfAccruingAndTotalNonAccruingLoansDetails">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablesPeriodPastDueAxis" xlink:label="Locator_us-gaap_FinancingReceivablesPeriodPastDueAxis_3323" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablesPeriodPastDueDomain" xlink:label="Locator_us-gaap_FinancingReceivablesPeriodPastDueDomain_3324" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_FinancingReceivablesPeriodPastDueAxis_3323" xlink:to="Locator_us-gaap_FinancingReceivablesPeriodPastDueDomain_3324" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablesPeriodPastDueAxis" xlink:label="Locator_us-gaap_FinancingReceivablesPeriodPastDueAxis_3361" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablesPeriodPastDueDomain" xlink:label="Locator_us-gaap_FinancingReceivablesPeriodPastDueDomain_3362" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_us-gaap_FinancingReceivablesPeriodPastDueAxis_3361" xlink:to="Locator_us-gaap_FinancingReceivablesPeriodPastDueDomain_3362" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablesPeriodPastDueDomain" xlink:label="Locator_us-gaap_FinancingReceivablesPeriodPastDueDomain_3325" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialAssetNotPastDueMember" xlink:label="Locator_us-gaap_FinancialAssetNotPastDueMember_3326" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablesPeriodPastDueDomain_3325" xlink:to="Locator_us-gaap_FinancialAssetNotPastDueMember_3326" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablesPeriodPastDueDomain" xlink:label="Locator_us-gaap_FinancingReceivablesPeriodPastDueDomain_3327" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_FinancialAsset30To89DaysPastDueMember" xlink:label="Locator_uscb_FinancialAsset30To89DaysPastDueMember_3328" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablesPeriodPastDueDomain_3327" xlink:to="Locator_uscb_FinancialAsset30To89DaysPastDueMember_3328" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentAxis" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentAxis_3311" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3312" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentAxis_3311" xlink:to="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3312" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3319" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_ForeignBanksMember" xlink:label="Locator_uscb_ForeignBanksMember_3320" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3319" xlink:to="Locator_uscb_ForeignBanksMember_3320" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3313" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResidentialPortfolioSegmentMember" xlink:label="Locator_us-gaap_ResidentialPortfolioSegmentMember_3314" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3313" xlink:to="Locator_us-gaap_ResidentialPortfolioSegmentMember_3314" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3315" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommercialRealEstatePortfolioSegmentMember" xlink:label="Locator_us-gaap_CommercialRealEstatePortfolioSegmentMember_3316" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3315" xlink:to="Locator_us-gaap_CommercialRealEstatePortfolioSegmentMember_3316" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3317" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_CommercialAndIndustrialMember" xlink:label="Locator_uscb_CommercialAndIndustrialMember_3318" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3317" xlink:to="Locator_uscb_CommercialAndIndustrialMember_3318" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3321" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_ConsumerAndOtherMember" xlink:label="Locator_uscb_ConsumerAndOtherMember_3322" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3321" xlink:to="Locator_uscb_ConsumerAndOtherMember_3322" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis" xlink:label="Locator_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_3329" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain" xlink:label="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3330" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_3329" xlink:to="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3330" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain" xlink:label="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3331" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_HomeEquityLineOfCreditAndOtherMember" xlink:label="Locator_uscb_HomeEquityLineOfCreditAndOtherMember_3332" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3331" xlink:to="Locator_uscb_HomeEquityLineOfCreditAndOtherMember_3332" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain" xlink:label="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3333" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_OneToFourFamilyResidentialMember" xlink:label="Locator_uscb_OneToFourFamilyResidentialMember_3334" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3333" xlink:to="Locator_uscb_OneToFourFamilyResidentialMember_3334" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain" xlink:label="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3335" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_CondoResidentialMember" xlink:label="Locator_uscb_CondoResidentialMember_3336" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3335" xlink:to="Locator_uscb_CondoResidentialMember_3336" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain" xlink:label="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3337" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_LandAndConstructionMember" xlink:label="Locator_uscb_LandAndConstructionMember_3338" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3337" xlink:to="Locator_uscb_LandAndConstructionMember_3338" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain" xlink:label="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3339" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_MultifamilyResidentialMember" xlink:label="Locator_uscb_MultifamilyResidentialMember_3340" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3339" xlink:to="Locator_uscb_MultifamilyResidentialMember_3340" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain" xlink:label="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3341" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_CondoCommercialMember" xlink:label="Locator_uscb_CondoCommercialMember_3342" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3341" xlink:to="Locator_uscb_CondoCommercialMember_3342" order="6.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain" xlink:label="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3343" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_CommercialPropertyMember" xlink:label="Locator_uscb_CommercialPropertyMember_3344" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3343" xlink:to="Locator_uscb_CommercialPropertyMember_3344" order="7.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain" xlink:label="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3345" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeaseholdImprovementsMember" xlink:label="Locator_us-gaap_LeaseholdImprovementsMember_3346" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3345" xlink:to="Locator_us-gaap_LeaseholdImprovementsMember_3346" order="8.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain" xlink:label="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3347" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_SecuredMember" xlink:label="Locator_uscb_SecuredMember_3348" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3347" xlink:to="Locator_uscb_SecuredMember_3348" order="9.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain" xlink:label="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3349" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_UnsecuredMember" xlink:label="Locator_uscb_UnsecuredMember_3350" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableRecordedInvestmentClassOfFinancingReceivableDomain_3349" xlink:to="Locator_uscb_UnsecuredMember_3350" order="10.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestmentPastDueLineItems" xlink:label="Locator_us-gaap_FinancingReceivableRecordedInvestmentPastDueLineItems_3293" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfFinancingReceivablesPastDueTable" xlink:label="Locator_us-gaap_ScheduleOfFinancingReceivablesPastDueTable_3294" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_us-gaap_FinancingReceivableRecordedInvestmentPastDueLineItems_3293" xlink:to="Locator_us-gaap_ScheduleOfFinancingReceivablesPastDueTable_3294" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfFinancingReceivablesPastDueTable" xlink:label="Locator_us-gaap_ScheduleOfFinancingReceivablesPastDueTable_3305" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablesPeriodPastDueAxis" xlink:label="Locator_us-gaap_FinancingReceivablesPeriodPastDueAxis_3306" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_ScheduleOfFinancingReceivablesPastDueTable_3305" xlink:to="Locator_us-gaap_FinancingReceivablesPeriodPastDueAxis_3306" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfFinancingReceivablesPastDueTable" xlink:label="Locator_us-gaap_ScheduleOfFinancingReceivablesPastDueTable_3307" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentAxis" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentAxis_3308" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_ScheduleOfFinancingReceivablesPastDueTable_3307" xlink:to="Locator_us-gaap_FinancingReceivablePortfolioSegmentAxis_3308" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfFinancingReceivablesPastDueTable" xlink:label="Locator_us-gaap_ScheduleOfFinancingReceivablesPastDueTable_3309" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis" xlink:label="Locator_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_3310" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_ScheduleOfFinancingReceivablesPastDueTable_3309" xlink:to="Locator_us-gaap_FinancingReceivableRecordedInvestmentByClassOfFinancingReceivableAxis_3310" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestmentPastDueLineItems" xlink:label="Locator_us-gaap_FinancingReceivableRecordedInvestmentPastDueLineItems_3351" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_FinancingReceivableExcludingNonAccrualBeforeAllowanceForCreditLoss" xlink:label="Locator_uscb_FinancingReceivableExcludingNonAccrualBeforeAllowanceForCreditLoss_3352" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableRecordedInvestmentPastDueLineItems_3351" xlink:to="Locator_uscb_FinancingReceivableExcludingNonAccrualBeforeAllowanceForCreditLoss_3352" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestmentPastDueLineItems" xlink:label="Locator_us-gaap_FinancingReceivableRecordedInvestmentPastDueLineItems_3353" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestment90DaysPastDueAndStillAccruing" xlink:label="Locator_us-gaap_FinancingReceivableRecordedInvestment90DaysPastDueAndStillAccruing_3354" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableRecordedInvestmentPastDueLineItems_3353" xlink:to="Locator_us-gaap_FinancingReceivableRecordedInvestment90DaysPastDueAndStillAccruing_3354" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestmentPastDueLineItems" xlink:label="Locator_us-gaap_FinancingReceivableRecordedInvestmentPastDueLineItems_3355" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_FinancingReceivableIncluding90DaysOrMorePastDueStillAccruingAndExcludingNonAccrualBeforeAllowanceForCreditLoss" xlink:label="Locator_uscb_FinancingReceivableIncluding90DaysOrMorePastDueStillAccruingAndExcludingNonAccrualBeforeAllowanceForCreditLoss_3356" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableRecordedInvestmentPastDueLineItems_3355" xlink:to="Locator_uscb_FinancingReceivableIncluding90DaysOrMorePastDueStillAccruingAndExcludingNonAccrualBeforeAllowanceForCreditLoss_3356" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestmentPastDueLineItems" xlink:label="Locator_us-gaap_FinancingReceivableRecordedInvestmentPastDueLineItems_3357" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestmentNonaccrualStatus" xlink:label="Locator_us-gaap_FinancingReceivableRecordedInvestmentNonaccrualStatus_3358" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableRecordedInvestmentPastDueLineItems_3357" xlink:to="Locator_us-gaap_FinancingReceivableRecordedInvestmentNonaccrualStatus_3358" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableRecordedInvestmentPastDueLineItems" xlink:label="Locator_us-gaap_FinancingReceivableRecordedInvestmentPastDueLineItems_3359" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NotesReceivableGross" xlink:label="Locator_us-gaap_NotesReceivableGross_3360" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableRecordedInvestmentPastDueLineItems_3359" xlink:to="Locator_us-gaap_NotesReceivableGross_3360" order="5.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/LoansImpairedLoansDetails">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentAxis" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentAxis_3435" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3436" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentAxis_3435" xlink:to="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3436" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3437" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_ForeignBanksMember" xlink:label="Locator_uscb_ForeignBanksMember_3438" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3437" xlink:to="Locator_uscb_ForeignBanksMember_3438" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3441" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResidentialPortfolioSegmentMember" xlink:label="Locator_us-gaap_ResidentialPortfolioSegmentMember_3442" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3441" xlink:to="Locator_us-gaap_ResidentialPortfolioSegmentMember_3442" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3443" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommercialRealEstatePortfolioSegmentMember" xlink:label="Locator_us-gaap_CommercialRealEstatePortfolioSegmentMember_3444" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3443" xlink:to="Locator_us-gaap_CommercialRealEstatePortfolioSegmentMember_3444" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3445" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_CommercialAndIndustrialMember" xlink:label="Locator_uscb_CommercialAndIndustrialMember_3446" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3445" xlink:to="Locator_uscb_CommercialAndIndustrialMember_3446" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3439" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_ConsumerAndOtherMember" xlink:label="Locator_uscb_ConsumerAndOtherMember_3440" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3439" xlink:to="Locator_uscb_ConsumerAndOtherMember_3440" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfImpairedFinancingReceivableTable" xlink:label="Locator_us-gaap_ScheduleOfImpairedFinancingReceivableTable_3447" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentAxis" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentAxis_3448" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_ScheduleOfImpairedFinancingReceivableTable_3447" xlink:to="Locator_us-gaap_FinancingReceivablePortfolioSegmentAxis_3448" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableImpairedLineItems" xlink:label="Locator_us-gaap_FinancingReceivableImpairedLineItems_3449" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfImpairedFinancingReceivableTable" xlink:label="Locator_us-gaap_ScheduleOfImpairedFinancingReceivableTable_3450" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_us-gaap_FinancingReceivableImpairedLineItems_3449" xlink:to="Locator_us-gaap_ScheduleOfImpairedFinancingReceivableTable_3450" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableImpairedLineItems" xlink:label="Locator_us-gaap_FinancingReceivableImpairedLineItems_3451" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ImpairedFinancingReceivableWithNoRelatedAllowanceUnpaidPrincipalBalance" xlink:label="Locator_us-gaap_ImpairedFinancingReceivableWithNoRelatedAllowanceUnpaidPrincipalBalance_3452" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableImpairedLineItems_3451" xlink:to="Locator_us-gaap_ImpairedFinancingReceivableWithNoRelatedAllowanceUnpaidPrincipalBalance_3452" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableImpairedLineItems" xlink:label="Locator_us-gaap_FinancingReceivableImpairedLineItems_3453" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ImpairedFinancingReceivableWithRelatedAllowanceUnpaidPrincipalBalance" xlink:label="Locator_us-gaap_ImpairedFinancingReceivableWithRelatedAllowanceUnpaidPrincipalBalance_3454" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableImpairedLineItems_3453" xlink:to="Locator_us-gaap_ImpairedFinancingReceivableWithRelatedAllowanceUnpaidPrincipalBalance_3454" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableImpairedLineItems" xlink:label="Locator_us-gaap_FinancingReceivableImpairedLineItems_3455" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ImpairedFinancingReceivableUnpaidPrincipalBalance" xlink:label="Locator_us-gaap_ImpairedFinancingReceivableUnpaidPrincipalBalance_3456" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableImpairedLineItems_3455" xlink:to="Locator_us-gaap_ImpairedFinancingReceivableUnpaidPrincipalBalance_3456" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableImpairedLineItems" xlink:label="Locator_us-gaap_FinancingReceivableImpairedLineItems_3457" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ImpairedFinancingReceivableWithRelatedAllowanceRecordedInvestment" xlink:label="Locator_us-gaap_ImpairedFinancingReceivableWithRelatedAllowanceRecordedInvestment_3458" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableImpairedLineItems_3457" xlink:to="Locator_us-gaap_ImpairedFinancingReceivableWithRelatedAllowanceRecordedInvestment_3458" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableImpairedLineItems" xlink:label="Locator_us-gaap_FinancingReceivableImpairedLineItems_3459" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ImpairedFinancingReceivableWithNoRelatedAllowanceRecordedInvestment" xlink:label="Locator_us-gaap_ImpairedFinancingReceivableWithNoRelatedAllowanceRecordedInvestment_3460" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableImpairedLineItems_3459" xlink:to="Locator_us-gaap_ImpairedFinancingReceivableWithNoRelatedAllowanceRecordedInvestment_3460" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableImpairedLineItems" xlink:label="Locator_us-gaap_FinancingReceivableImpairedLineItems_3461" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ImpairedFinancingReceivableRecordedInvestment" xlink:label="Locator_us-gaap_ImpairedFinancingReceivableRecordedInvestment_3462" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableImpairedLineItems_3461" xlink:to="Locator_us-gaap_ImpairedFinancingReceivableRecordedInvestment_3462" order="6.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableImpairedLineItems" xlink:label="Locator_us-gaap_FinancingReceivableImpairedLineItems_3463" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ImpairedFinancingReceivableRelatedAllowance" xlink:label="Locator_us-gaap_ImpairedFinancingReceivableRelatedAllowance_3464" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableImpairedLineItems_3463" xlink:to="Locator_us-gaap_ImpairedFinancingReceivableRelatedAllowance_3464" order="7.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableImpairedLineItems" xlink:label="Locator_us-gaap_FinancingReceivableImpairedLineItems_3465" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ImpairedFinancingReceivableAverageRecordedInvestment" xlink:label="Locator_us-gaap_ImpairedFinancingReceivableAverageRecordedInvestment_3466" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableImpairedLineItems_3465" xlink:to="Locator_us-gaap_ImpairedFinancingReceivableAverageRecordedInvestment_3466" order="8.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/LoansPerformingAndNonPerformingTroubledDebtRestructuringsDetails">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentAxis" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentAxis_3487" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3488" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentAxis_3487" xlink:to="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3488" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3489" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_ForeignBanksMember" xlink:label="Locator_uscb_ForeignBanksMember_3490" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3489" xlink:to="Locator_uscb_ForeignBanksMember_3490" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3493" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResidentialPortfolioSegmentMember" xlink:label="Locator_us-gaap_ResidentialPortfolioSegmentMember_3494" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3493" xlink:to="Locator_us-gaap_ResidentialPortfolioSegmentMember_3494" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3495" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommercialRealEstatePortfolioSegmentMember" xlink:label="Locator_us-gaap_CommercialRealEstatePortfolioSegmentMember_3496" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3495" xlink:to="Locator_us-gaap_CommercialRealEstatePortfolioSegmentMember_3496" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3497" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_CommercialAndIndustrialMember" xlink:label="Locator_uscb_CommercialAndIndustrialMember_3498" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3497" xlink:to="Locator_uscb_CommercialAndIndustrialMember_3498" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3491" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_ConsumerAndOtherMember" xlink:label="Locator_uscb_ConsumerAndOtherMember_3492" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3491" xlink:to="Locator_uscb_ConsumerAndOtherMember_3492" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableModificationsLineItems" xlink:label="Locator_us-gaap_FinancingReceivableModificationsLineItems_3499" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableModificationsRecordedInvestment" xlink:label="Locator_us-gaap_FinancingReceivableModificationsRecordedInvestment_3500" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableModificationsLineItems_3499" xlink:to="Locator_us-gaap_FinancingReceivableModificationsRecordedInvestment_3500" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableModificationsLineItems" xlink:label="Locator_us-gaap_FinancingReceivableModificationsLineItems_3501" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfImpairedFinancingReceivableTable" xlink:label="Locator_us-gaap_ScheduleOfImpairedFinancingReceivableTable_3502" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_us-gaap_FinancingReceivableModificationsLineItems_3501" xlink:to="Locator_us-gaap_ScheduleOfImpairedFinancingReceivableTable_3502" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfImpairedFinancingReceivableTable" xlink:label="Locator_us-gaap_ScheduleOfImpairedFinancingReceivableTable_3503" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentPerformanceStatusAxis" xlink:label="Locator_us-gaap_FinancialInstrumentPerformanceStatusAxis_3504" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_ScheduleOfImpairedFinancingReceivableTable_3503" xlink:to="Locator_us-gaap_FinancialInstrumentPerformanceStatusAxis_3504" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentPerformanceStatusAxis" xlink:label="Locator_us-gaap_FinancialInstrumentPerformanceStatusAxis_3505" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentPerformanceStatusDomain" xlink:label="Locator_us-gaap_FinancialInstrumentPerformanceStatusDomain_3506" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_FinancialInstrumentPerformanceStatusAxis_3505" xlink:to="Locator_us-gaap_FinancialInstrumentPerformanceStatusDomain_3506" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentPerformanceStatusAxis" xlink:label="Locator_us-gaap_FinancialInstrumentPerformanceStatusAxis_3507" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentPerformanceStatusDomain" xlink:label="Locator_us-gaap_FinancialInstrumentPerformanceStatusDomain_3508" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_us-gaap_FinancialInstrumentPerformanceStatusAxis_3507" xlink:to="Locator_us-gaap_FinancialInstrumentPerformanceStatusDomain_3508" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentPerformanceStatusDomain" xlink:label="Locator_us-gaap_FinancialInstrumentPerformanceStatusDomain_3509" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PerformingFinancingReceivableMember" xlink:label="Locator_us-gaap_PerformingFinancingReceivableMember_3510" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancialInstrumentPerformanceStatusDomain_3509" xlink:to="Locator_us-gaap_PerformingFinancingReceivableMember_3510" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentPerformanceStatusDomain" xlink:label="Locator_us-gaap_FinancialInstrumentPerformanceStatusDomain_3511" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NonperformingFinancingReceivableMember" xlink:label="Locator_us-gaap_NonperformingFinancingReceivableMember_3512" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancialInstrumentPerformanceStatusDomain_3511" xlink:to="Locator_us-gaap_NonperformingFinancingReceivableMember_3512" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfImpairedFinancingReceivableTable" xlink:label="Locator_us-gaap_ScheduleOfImpairedFinancingReceivableTable_3513" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentAxis" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentAxis_3514" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_ScheduleOfImpairedFinancingReceivableTable_3513" xlink:to="Locator_us-gaap_FinancingReceivablePortfolioSegmentAxis_3514" order="2.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/LoansTroubledDebtRestructuringLoansDetails">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentAxis" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentAxis_3555" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3556" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentAxis_3555" xlink:to="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3556" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3557" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResidentialPortfolioSegmentMember" xlink:label="Locator_us-gaap_ResidentialPortfolioSegmentMember_3558" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3557" xlink:to="Locator_us-gaap_ResidentialPortfolioSegmentMember_3558" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3559" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommercialRealEstatePortfolioSegmentMember" xlink:label="Locator_us-gaap_CommercialRealEstatePortfolioSegmentMember_3560" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3559" xlink:to="Locator_us-gaap_CommercialRealEstatePortfolioSegmentMember_3560" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3561" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_CommercialAndIndustrialMember" xlink:label="Locator_uscb_CommercialAndIndustrialMember_3562" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3561" xlink:to="Locator_uscb_CommercialAndIndustrialMember_3562" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentDomain" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3563" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_ConsumerAndOtherMember" xlink:label="Locator_uscb_ConsumerAndOtherMember_3564" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivablePortfolioSegmentDomain_3563" xlink:to="Locator_uscb_ConsumerAndOtherMember_3564" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableModificationsLineItems" xlink:label="Locator_us-gaap_FinancingReceivableModificationsLineItems_3547" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfImpairedFinancingReceivableTable" xlink:label="Locator_us-gaap_ScheduleOfImpairedFinancingReceivableTable_3548" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_us-gaap_FinancingReceivableModificationsLineItems_3547" xlink:to="Locator_us-gaap_ScheduleOfImpairedFinancingReceivableTable_3548" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfImpairedFinancingReceivableTable" xlink:label="Locator_us-gaap_ScheduleOfImpairedFinancingReceivableTable_3551" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LoanRestructuringModificationAxis" xlink:label="Locator_us-gaap_LoanRestructuringModificationAxis_3552" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_ScheduleOfImpairedFinancingReceivableTable_3551" xlink:to="Locator_us-gaap_LoanRestructuringModificationAxis_3552" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LoanRestructuringModificationAxis" xlink:label="Locator_us-gaap_LoanRestructuringModificationAxis_3565" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LoanRestructuringModificationDomain" xlink:label="Locator_us-gaap_LoanRestructuringModificationDomain_3566" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_LoanRestructuringModificationAxis_3565" xlink:to="Locator_us-gaap_LoanRestructuringModificationDomain_3566" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LoanRestructuringModificationAxis" xlink:label="Locator_us-gaap_LoanRestructuringModificationAxis_3577" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LoanRestructuringModificationDomain" xlink:label="Locator_us-gaap_LoanRestructuringModificationDomain_3578" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_us-gaap_LoanRestructuringModificationAxis_3577" xlink:to="Locator_us-gaap_LoanRestructuringModificationDomain_3578" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LoanRestructuringModificationDomain" xlink:label="Locator_us-gaap_LoanRestructuringModificationDomain_3567" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_PaymentModificationsMember" xlink:label="Locator_uscb_PaymentModificationsMember_3568" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_LoanRestructuringModificationDomain_3567" xlink:to="Locator_uscb_PaymentModificationsMember_3568" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LoanRestructuringModificationDomain" xlink:label="Locator_us-gaap_LoanRestructuringModificationDomain_3569" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_CombinationModificationsMember" xlink:label="Locator_uscb_CombinationModificationsMember_3570" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_LoanRestructuringModificationDomain_3569" xlink:to="Locator_uscb_CombinationModificationsMember_3570" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfImpairedFinancingReceivableTable" xlink:label="Locator_us-gaap_ScheduleOfImpairedFinancingReceivableTable_3553" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivablePortfolioSegmentAxis" xlink:label="Locator_us-gaap_FinancingReceivablePortfolioSegmentAxis_3554" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_ScheduleOfImpairedFinancingReceivableTable_3553" xlink:to="Locator_us-gaap_FinancingReceivablePortfolioSegmentAxis_3554" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableModificationsLineItems" xlink:label="Locator_us-gaap_FinancingReceivableModificationsLineItems_3571" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableModificationsNumberOfContracts2" xlink:label="Locator_us-gaap_FinancingReceivableModificationsNumberOfContracts2_3572" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableModificationsLineItems_3571" xlink:to="Locator_us-gaap_FinancingReceivableModificationsNumberOfContracts2_3572" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableModificationsLineItems" xlink:label="Locator_us-gaap_FinancingReceivableModificationsLineItems_3573" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableModificationsPreModificationRecordedInvestment2" xlink:label="Locator_us-gaap_FinancingReceivableModificationsPreModificationRecordedInvestment2_3574" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableModificationsLineItems_3573" xlink:to="Locator_us-gaap_FinancingReceivableModificationsPreModificationRecordedInvestment2_3574" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableModificationsLineItems" xlink:label="Locator_us-gaap_FinancingReceivableModificationsLineItems_3575" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancingReceivableModificationsPostModificationRecordedInvestment2" xlink:label="Locator_us-gaap_FinancingReceivableModificationsPostModificationRecordedInvestment2_3576" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancingReceivableModificationsLineItems_3575" xlink:to="Locator_us-gaap_FinancingReceivableModificationsPostModificationRecordedInvestment2_3576" order="3.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/FairValueMeasurementsScheduleOfAssetsMeasuredAtFairValueOnRecurringAndNonrecurringBasisDetails">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="Locator_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3629" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel1Member" xlink:label="Locator_us-gaap_FairValueInputsLevel1Member_3630" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3629" xlink:to="Locator_us-gaap_FairValueInputsLevel1Member_3630" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="Locator_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3631" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="Locator_us-gaap_FairValueInputsLevel2Member_3632" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3631" xlink:to="Locator_us-gaap_FairValueInputsLevel2Member_3632" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="Locator_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3633" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel3Member" xlink:label="Locator_us-gaap_FairValueInputsLevel3Member_3634" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3633" xlink:to="Locator_us-gaap_FairValueInputsLevel3Member_3634" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:label="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_3615" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:label="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3616" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_3615" xlink:to="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3616" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:label="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3623" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="Locator_us-gaap_FairValueByFairValueHierarchyLevelAxis_3624" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3623" xlink:to="Locator_us-gaap_FairValueByFairValueHierarchyLevelAxis_3624" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="Locator_us-gaap_FairValueByFairValueHierarchyLevelAxis_3635" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="Locator_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3636" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_FairValueByFairValueHierarchyLevelAxis_3635" xlink:to="Locator_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3636" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:label="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3625" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByAssetClassAxis" xlink:label="Locator_us-gaap_FairValueByAssetClassAxis_3626" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3625" xlink:to="Locator_us-gaap_FairValueByAssetClassAxis_3626" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByAssetClassAxis" xlink:label="Locator_us-gaap_FairValueByAssetClassAxis_3637" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="Locator_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_3638" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_FairValueByAssetClassAxis_3637" xlink:to="Locator_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_3638" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="Locator_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_3639" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember" xlink:label="Locator_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_3640" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_3639" xlink:to="Locator_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_3640" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="Locator_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_3641" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USTreasurySecuritiesMember" xlink:label="Locator_us-gaap_USTreasurySecuritiesMember_3642" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_3641" xlink:to="Locator_us-gaap_USTreasurySecuritiesMember_3642" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="Locator_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_3643" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CollateralizedMortgageObligationsMember" xlink:label="Locator_us-gaap_CollateralizedMortgageObligationsMember_3644" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_3643" xlink:to="Locator_us-gaap_CollateralizedMortgageObligationsMember_3644" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="Locator_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_3645" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResidentialMortgageBackedSecuritiesMember" xlink:label="Locator_us-gaap_ResidentialMortgageBackedSecuritiesMember_3646" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_3645" xlink:to="Locator_us-gaap_ResidentialMortgageBackedSecuritiesMember_3646" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="Locator_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_3647" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommercialMortgageBackedSecuritiesMember" xlink:label="Locator_us-gaap_CommercialMortgageBackedSecuritiesMember_3648" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_3647" xlink:to="Locator_us-gaap_CommercialMortgageBackedSecuritiesMember_3648" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="Locator_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_3649" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_USStatesAndPoliticalSubdivisionsMember" xlink:label="Locator_us-gaap_USStatesAndPoliticalSubdivisionsMember_3650" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_3649" xlink:to="Locator_us-gaap_USStatesAndPoliticalSubdivisionsMember_3650" order="6.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="Locator_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_3651" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_BankSubordinatedDebtSecuritiesMember" xlink:label="Locator_uscb_BankSubordinatedDebtSecuritiesMember_3652" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_3651" xlink:to="Locator_uscb_BankSubordinatedDebtSecuritiesMember_3652" order="7.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="Locator_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_3653" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CorporateBondSecuritiesMember" xlink:label="Locator_us-gaap_CorporateBondSecuritiesMember_3654" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_3653" xlink:to="Locator_us-gaap_CorporateBondSecuritiesMember_3654" order="8.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="Locator_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_3655" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_ImpairedLoansMember" xlink:label="Locator_uscb_ImpairedLoansMember_3656" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_3655" xlink:to="Locator_uscb_ImpairedLoansMember_3656" order="9.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:label="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3627" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByMeasurementFrequencyAxis" xlink:label="Locator_us-gaap_FairValueByMeasurementFrequencyAxis_3628" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3627" xlink:to="Locator_us-gaap_FairValueByMeasurementFrequencyAxis_3628" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByMeasurementFrequencyAxis" xlink:label="Locator_us-gaap_FairValueByMeasurementFrequencyAxis_3657" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementFrequencyDomain" xlink:label="Locator_us-gaap_FairValueMeasurementFrequencyDomain_3658" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_FairValueByMeasurementFrequencyAxis_3657" xlink:to="Locator_us-gaap_FairValueMeasurementFrequencyDomain_3658" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementFrequencyDomain" xlink:label="Locator_us-gaap_FairValueMeasurementFrequencyDomain_3659" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsRecurringMember" xlink:label="Locator_us-gaap_FairValueMeasurementsRecurringMember_3660" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FairValueMeasurementFrequencyDomain_3659" xlink:to="Locator_us-gaap_FairValueMeasurementsRecurringMember_3660" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementFrequencyDomain" xlink:label="Locator_us-gaap_FairValueMeasurementFrequencyDomain_3661" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsNonrecurringMember" xlink:label="Locator_us-gaap_FairValueMeasurementsNonrecurringMember_3662" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FairValueMeasurementFrequencyDomain_3661" xlink:to="Locator_us-gaap_FairValueMeasurementsNonrecurringMember_3662" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:label="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_3663" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:label="Locator_us-gaap_AvailableForSaleSecuritiesDebtSecurities_3664" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_3663" xlink:to="Locator_us-gaap_AvailableForSaleSecuritiesDebtSecurities_3664" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:label="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_3665" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeAssets" xlink:label="Locator_us-gaap_DerivativeAssets_3666" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_3665" xlink:to="Locator_us-gaap_DerivativeAssets_3666" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:label="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_3667" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsFairValueDisclosure" xlink:label="Locator_us-gaap_AssetsFairValueDisclosure_3668" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_3667" xlink:to="Locator_us-gaap_AssetsFairValueDisclosure_3668" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:label="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_3669" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DerivativeLiabilities" xlink:label="Locator_us-gaap_DerivativeLiabilities_3670" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_3669" xlink:to="Locator_us-gaap_DerivativeLiabilities_3670" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:label="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_3671" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialLiabilitiesFairValueDisclosure" xlink:label="Locator_us-gaap_FinancialLiabilitiesFairValueDisclosure_3672" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_3671" xlink:to="Locator_us-gaap_FinancialLiabilitiesFairValueDisclosure_3672" order="5.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/FairValueMeasurementsQuantifiedInformationAboutLevel3FairValueMeasurementsForAssetsMeasuredAtFairValueOnANonrecurringBasisDetails">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="Locator_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3717" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel3Member" xlink:label="Locator_us-gaap_FairValueInputsLevel3Member_3718" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3717" xlink:to="Locator_us-gaap_FairValueInputsLevel3Member_3718" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_3719" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResidentialRealEstateMember" xlink:label="Locator_us-gaap_ResidentialRealEstateMember_3720" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_3719" xlink:to="Locator_us-gaap_ResidentialRealEstateMember_3720" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_3721" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_CommercialAndIndustrialLoansMember" xlink:label="Locator_uscb_CommercialAndIndustrialLoansMember_3722" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_3721" xlink:to="Locator_uscb_CommercialAndIndustrialLoansMember_3722" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_3723" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_OtherImpairedLoansMember" xlink:label="Locator_uscb_OtherImpairedLoansMember_3724" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_3723" xlink:to="Locator_uscb_OtherImpairedLoansMember_3724" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationTechniqueDomain" xlink:label="Locator_us-gaap_ValuationTechniqueDomain_3725" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_SalesComparisonApproachMember" xlink:label="Locator_uscb_SalesComparisonApproachMember_3726" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ValuationTechniqueDomain_3725" xlink:to="Locator_uscb_SalesComparisonApproachMember_3726" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationTechniqueDomain" xlink:label="Locator_us-gaap_ValuationTechniqueDomain_3727" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationTechniqueDiscountedCashFlowMember" xlink:label="Locator_us-gaap_ValuationTechniqueDiscountedCashFlowMember_3728" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ValuationTechniqueDomain_3727" xlink:to="Locator_us-gaap_ValuationTechniqueDiscountedCashFlowMember_3728" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="Locator_us-gaap_FinancialInstrumentAxis_3729" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_3730" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_FinancialInstrumentAxis_3729" xlink:to="Locator_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_3730" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="Locator_us-gaap_FairValueByFairValueHierarchyLevelAxis_3731" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="Locator_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3732" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_FairValueByFairValueHierarchyLevelAxis_3731" xlink:to="Locator_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3732" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByAssetClassAxis" xlink:label="Locator_us-gaap_FairValueByAssetClassAxis_3733" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="Locator_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_3734" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_FairValueByAssetClassAxis_3733" xlink:to="Locator_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_3734" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:label="Locator_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_3735" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_ImpairedLoansMember" xlink:label="Locator_uscb_ImpairedLoansMember_3736" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_3735" xlink:to="Locator_uscb_ImpairedLoansMember_3736" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByMeasurementFrequencyAxis" xlink:label="Locator_us-gaap_FairValueByMeasurementFrequencyAxis_3737" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementFrequencyDomain" xlink:label="Locator_us-gaap_FairValueMeasurementFrequencyDomain_3738" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_FairValueByMeasurementFrequencyAxis_3737" xlink:to="Locator_us-gaap_FairValueMeasurementFrequencyDomain_3738" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementFrequencyDomain" xlink:label="Locator_us-gaap_FairValueMeasurementFrequencyDomain_3739" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsNonrecurringMember" xlink:label="Locator_us-gaap_FairValueMeasurementsNonrecurringMember_3740" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FairValueMeasurementFrequencyDomain_3739" xlink:to="Locator_us-gaap_FairValueMeasurementsNonrecurringMember_3740" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesLineItems" xlink:label="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesLineItems_3741" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable" xlink:label="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable_3742" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesLineItems_3741" xlink:to="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable_3742" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable" xlink:label="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable_3743" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByMeasurementFrequencyAxis" xlink:label="Locator_us-gaap_FairValueByMeasurementFrequencyAxis_3744" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable_3743" xlink:to="Locator_us-gaap_FairValueByMeasurementFrequencyAxis_3744" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable" xlink:label="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable_3745" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="Locator_us-gaap_FairValueByFairValueHierarchyLevelAxis_3746" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable_3745" xlink:to="Locator_us-gaap_FairValueByFairValueHierarchyLevelAxis_3746" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable" xlink:label="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable_3747" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByAssetClassAxis" xlink:label="Locator_us-gaap_FairValueByAssetClassAxis_3748" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable_3747" xlink:to="Locator_us-gaap_FairValueByAssetClassAxis_3748" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable" xlink:label="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable_3749" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="Locator_us-gaap_FinancialInstrumentAxis_3750" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable_3749" xlink:to="Locator_us-gaap_FinancialInstrumentAxis_3750" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable" xlink:label="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable_3751" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationTechniqueAxis" xlink:label="Locator_us-gaap_ValuationTechniqueAxis_3752" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTable_3751" xlink:to="Locator_us-gaap_ValuationTechniqueAxis_3752" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationTechniqueAxis" xlink:label="Locator_us-gaap_ValuationTechniqueAxis_3753" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationTechniqueDomain" xlink:label="Locator_us-gaap_ValuationTechniqueDomain_3754" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_ValuationTechniqueAxis_3753" xlink:to="Locator_us-gaap_ValuationTechniqueDomain_3754" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationTechniqueAxis" xlink:label="Locator_us-gaap_ValuationTechniqueAxis_3755" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationTechniqueDomain" xlink:label="Locator_us-gaap_ValuationTechniqueDomain_3756" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_us-gaap_ValuationTechniqueAxis_3755" xlink:to="Locator_us-gaap_ValuationTechniqueDomain_3756" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesLineItems" xlink:label="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesLineItems_3757" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsFairValueDisclosure" xlink:label="Locator_us-gaap_AssetsFairValueDisclosure_3758" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesLineItems_3757" xlink:to="Locator_us-gaap_AssetsFairValueDisclosure_3758" order="1.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/FairValueMeasurementsCarryingAmountsAndEstimatedFairValuesOfFinancialInstrumentsNotCarriedAtFairValueDetails">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="Locator_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3833" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel1Member" xlink:label="Locator_us-gaap_FairValueInputsLevel1Member_3834" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3833" xlink:to="Locator_us-gaap_FairValueInputsLevel1Member_3834" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="Locator_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3835" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="Locator_us-gaap_FairValueInputsLevel2Member_3836" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3835" xlink:to="Locator_us-gaap_FairValueInputsLevel2Member_3836" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="Locator_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3837" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel3Member" xlink:label="Locator_us-gaap_FairValueInputsLevel3Member_3838" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3837" xlink:to="Locator_us-gaap_FairValueInputsLevel3Member_3838" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="Locator_us-gaap_FairValueByFairValueHierarchyLevelAxis_3839" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="Locator_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3840" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_FairValueByFairValueHierarchyLevelAxis_3839" xlink:to="Locator_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_3840" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems" xlink:label="Locator_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_3803" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByBalanceSheetGroupingTable" xlink:label="Locator_us-gaap_FairValueByBalanceSheetGroupingTable_3804" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_3803" xlink:to="Locator_us-gaap_FairValueByBalanceSheetGroupingTable_3804" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByBalanceSheetGroupingTable" xlink:label="Locator_us-gaap_FairValueByBalanceSheetGroupingTable_3829" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByMeasurementBasisAxis" xlink:label="Locator_us-gaap_FairValueByMeasurementBasisAxis_3830" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_FairValueByBalanceSheetGroupingTable_3829" xlink:to="Locator_us-gaap_FairValueByMeasurementBasisAxis_3830" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByMeasurementBasisAxis" xlink:label="Locator_us-gaap_FairValueByMeasurementBasisAxis_3841" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember" xlink:label="Locator_us-gaap_PortionAtFairValueFairValueDisclosureMember_3842" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_FairValueByMeasurementBasisAxis_3841" xlink:to="Locator_us-gaap_PortionAtFairValueFairValueDisclosureMember_3842" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByMeasurementBasisAxis" xlink:label="Locator_us-gaap_FairValueByMeasurementBasisAxis_3873" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember" xlink:label="Locator_us-gaap_PortionAtFairValueFairValueDisclosureMember_3874" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_us-gaap_FairValueByMeasurementBasisAxis_3873" xlink:to="Locator_us-gaap_PortionAtFairValueFairValueDisclosureMember_3874" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember" xlink:label="Locator_us-gaap_PortionAtFairValueFairValueDisclosureMember_3843" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CarryingReportedAmountFairValueDisclosureMember" xlink:label="Locator_us-gaap_CarryingReportedAmountFairValueDisclosureMember_3844" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_PortionAtFairValueFairValueDisclosureMember_3843" xlink:to="Locator_us-gaap_CarryingReportedAmountFairValueDisclosureMember_3844" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember" xlink:label="Locator_us-gaap_PortionAtFairValueFairValueDisclosureMember_3845" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EstimateOfFairValueFairValueDisclosureMember" xlink:label="Locator_us-gaap_EstimateOfFairValueFairValueDisclosureMember_3846" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_PortionAtFairValueFairValueDisclosureMember_3845" xlink:to="Locator_us-gaap_EstimateOfFairValueFairValueDisclosureMember_3846" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByBalanceSheetGroupingTable" xlink:label="Locator_us-gaap_FairValueByBalanceSheetGroupingTable_3831" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="Locator_us-gaap_FairValueByFairValueHierarchyLevelAxis_3832" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_FairValueByBalanceSheetGroupingTable_3831" xlink:to="Locator_us-gaap_FairValueByFairValueHierarchyLevelAxis_3832" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems" xlink:label="Locator_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_3847" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract" xlink:label="Locator_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_3848" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_3847" xlink:to="Locator_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_3848" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract" xlink:label="Locator_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_3849" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure" xlink:label="Locator_us-gaap_CashAndCashEquivalentsFairValueDisclosure_3850" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_3849" xlink:to="Locator_us-gaap_CashAndCashEquivalentsFairValueDisclosure_3850" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract" xlink:label="Locator_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_3851" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_InterestBearingDepositsInBanksFairValue" xlink:label="Locator_uscb_InterestBearingDepositsInBanksFairValue_3852" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_3851" xlink:to="Locator_uscb_InterestBearingDepositsInBanksFairValue_3852" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract" xlink:label="Locator_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_3853" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_HeldToMaturitySecuritiesFairValue" xlink:label="Locator_us-gaap_HeldToMaturitySecuritiesFairValue_3854" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_3853" xlink:to="Locator_us-gaap_HeldToMaturitySecuritiesFairValue_3854" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract" xlink:label="Locator_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_3855" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LoansReceivableFairValueDisclosure" xlink:label="Locator_us-gaap_LoansReceivableFairValueDisclosure_3856" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_3855" xlink:to="Locator_us-gaap_LoansReceivableFairValueDisclosure_3856" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract" xlink:label="Locator_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_3857" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_AccruedInterestReceivableFairValueDisclosure" xlink:label="Locator_uscb_AccruedInterestReceivableFairValueDisclosure_3858" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancialInstrumentsFinancialAssetsBalanceSheetGroupingsAbstract_3857" xlink:to="Locator_uscb_AccruedInterestReceivableFairValueDisclosure_3858" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems" xlink:label="Locator_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_3859" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentsFinancialLiabilitiesBalanceSheetGroupingsAbstract" xlink:label="Locator_us-gaap_FinancialInstrumentsFinancialLiabilitiesBalanceSheetGroupingsAbstract_3860" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FairValueBalanceSheetGroupingFinancialStatementCaptionsLineItems_3859" xlink:to="Locator_us-gaap_FinancialInstrumentsFinancialLiabilitiesBalanceSheetGroupingsAbstract_3860" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentsFinancialLiabilitiesBalanceSheetGroupingsAbstract" xlink:label="Locator_us-gaap_FinancialInstrumentsFinancialLiabilitiesBalanceSheetGroupingsAbstract_3861" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DemandDepositsFairValueDisclosure" xlink:label="Locator_uscb_DemandDepositsFairValueDisclosure_3862" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancialInstrumentsFinancialLiabilitiesBalanceSheetGroupingsAbstract_3861" xlink:to="Locator_uscb_DemandDepositsFairValueDisclosure_3862" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentsFinancialLiabilitiesBalanceSheetGroupingsAbstract" xlink:label="Locator_us-gaap_FinancialInstrumentsFinancialLiabilitiesBalanceSheetGroupingsAbstract_3863" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_MoneyMarketAndSavingsAccountFairValueDisclosure" xlink:label="Locator_uscb_MoneyMarketAndSavingsAccountFairValueDisclosure_3864" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancialInstrumentsFinancialLiabilitiesBalanceSheetGroupingsAbstract_3863" xlink:to="Locator_uscb_MoneyMarketAndSavingsAccountFairValueDisclosure_3864" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentsFinancialLiabilitiesBalanceSheetGroupingsAbstract" xlink:label="Locator_us-gaap_FinancialInstrumentsFinancialLiabilitiesBalanceSheetGroupingsAbstract_3865" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_InterestBearingCheckingAccountsFairValueDisclosure" xlink:label="Locator_uscb_InterestBearingCheckingAccountsFairValueDisclosure_3866" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancialInstrumentsFinancialLiabilitiesBalanceSheetGroupingsAbstract_3865" xlink:to="Locator_uscb_InterestBearingCheckingAccountsFairValueDisclosure_3866" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentsFinancialLiabilitiesBalanceSheetGroupingsAbstract" xlink:label="Locator_us-gaap_FinancialInstrumentsFinancialLiabilitiesBalanceSheetGroupingsAbstract_3867" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_TimeDepositsFairValueDisclosure" xlink:label="Locator_uscb_TimeDepositsFairValueDisclosure_3868" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancialInstrumentsFinancialLiabilitiesBalanceSheetGroupingsAbstract_3867" xlink:to="Locator_uscb_TimeDepositsFairValueDisclosure_3868" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentsFinancialLiabilitiesBalanceSheetGroupingsAbstract" xlink:label="Locator_us-gaap_FinancialInstrumentsFinancialLiabilitiesBalanceSheetGroupingsAbstract_3869" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentInFederalHomeLoanBankStockFairValueDisclosure" xlink:label="Locator_us-gaap_InvestmentInFederalHomeLoanBankStockFairValueDisclosure_3870" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancialInstrumentsFinancialLiabilitiesBalanceSheetGroupingsAbstract_3869" xlink:to="Locator_us-gaap_InvestmentInFederalHomeLoanBankStockFairValueDisclosure_3870" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialInstrumentsFinancialLiabilitiesBalanceSheetGroupingsAbstract" xlink:label="Locator_us-gaap_FinancialInstrumentsFinancialLiabilitiesBalanceSheetGroupingsAbstract_3871" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_AccruedInterestPayableFairValueDisclosure" xlink:label="Locator_uscb_AccruedInterestPayableFairValueDisclosure_3872" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_FinancialInstrumentsFinancialLiabilitiesBalanceSheetGroupingsAbstract_3871" xlink:to="Locator_uscb_AccruedInterestPayableFairValueDisclosure_3872" order="6.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/EquityBasedAndOtherCompensationPlansNarrativeDetails">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="Locator_us-gaap_StatementClassOfStockAxis_3937" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_3938" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_StatementClassOfStockAxis_3937" xlink:to="Locator_us-gaap_ClassOfStockDomain_3938" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_3939" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassAMember" xlink:label="Locator_us-gaap_CommonClassAMember_3940" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockDomain_3939" xlink:to="Locator_us-gaap_CommonClassAMember_3940" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3949" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DefinedContributionPlanCostRecognized" xlink:label="Locator_us-gaap_DefinedContributionPlanCostRecognized_3950" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3949" xlink:to="Locator_us-gaap_DefinedContributionPlanCostRecognized_3950" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3951" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityReverseStockSplit" xlink:label="Locator_us-gaap_StockholdersEquityReverseStockSplit_3952" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3951" xlink:to="Locator_us-gaap_StockholdersEquityReverseStockSplit_3952" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3953" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_3954" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3953" xlink:to="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_3954" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3955" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardRequisiteServicePeriod1" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardRequisiteServicePeriod1_3956" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3955" xlink:to="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardRequisiteServicePeriod1_3956" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3957" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod" xlink:label="Locator_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_3958" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3957" xlink:to="Locator_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_3958" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3959" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardExpirationDate" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardExpirationDate_3960" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3959" xlink:to="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardExpirationDate_3960" order="6.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3961" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized_3962" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3961" xlink:to="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized_3962" order="7.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3963" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_ShareBasedCompensationArrangementByShareBasedPaymentAwardExtendedLifeOfOptionPlan" xlink:label="Locator_uscb_ShareBasedCompensationArrangementByShareBasedPaymentAwardExtendedLifeOfOptionPlan_3964" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3963" xlink:to="Locator_uscb_ShareBasedCompensationArrangementByShareBasedPaymentAwardExtendedLifeOfOptionPlan_3964" order="8.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3965" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_3966" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3965" xlink:to="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_3966" order="9.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3967" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AllocatedShareBasedCompensationExpense" xlink:label="Locator_us-gaap_AllocatedShareBasedCompensationExpense_3968" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3967" xlink:to="Locator_us-gaap_AllocatedShareBasedCompensationExpense_3968" order="10.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3969" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense" xlink:label="Locator_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_3970" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3969" xlink:to="Locator_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_3970" order="11.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3971" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions" xlink:label="Locator_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_3972" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3971" xlink:to="Locator_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_3972" order="12.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3973" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_3974" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3973" xlink:to="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_3974" order="13.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3977" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber_3978" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3977" xlink:to="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber_3978" order="15.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3979" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfEquityCompensationPlansNotApprovedByShareholders" xlink:label="Locator_uscb_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfEquityCompensationPlansNotApprovedByShareholders_3980" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3979" xlink:to="Locator_uscb_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfEquityCompensationPlansNotApprovedByShareholders_3980" order="16.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3927" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="Locator_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_3928" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3927" xlink:to="Locator_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_3928" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="Locator_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_3933" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameAxis" xlink:label="Locator_us-gaap_PlanNameAxis_3934" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_3933" xlink:to="Locator_us-gaap_PlanNameAxis_3934" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameAxis" xlink:label="Locator_us-gaap_PlanNameAxis_3941" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameDomain" xlink:label="Locator_us-gaap_PlanNameDomain_3942" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_PlanNameAxis_3941" xlink:to="Locator_us-gaap_PlanNameDomain_3942" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameAxis" xlink:label="Locator_us-gaap_PlanNameAxis_3981" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameDomain" xlink:label="Locator_us-gaap_PlanNameDomain_3982" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_us-gaap_PlanNameAxis_3981" xlink:to="Locator_us-gaap_PlanNameDomain_3982" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameDomain" xlink:label="Locator_us-gaap_PlanNameDomain_3943" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_EquityIncentive2015PlanMember" xlink:label="Locator_uscb_EquityIncentive2015PlanMember_3944" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_PlanNameDomain_3943" xlink:to="Locator_uscb_EquityIncentive2015PlanMember_3944" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="Locator_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_3935" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis" xlink:label="Locator_us-gaap_AwardTypeAxis_3936" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_3935" xlink:to="Locator_us-gaap_AwardTypeAxis_3936" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis" xlink:label="Locator_us-gaap_AwardTypeAxis_3945" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_3946" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_AwardTypeAxis_3945" xlink:to="Locator_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_3946" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_3947" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedStockMember" xlink:label="Locator_us-gaap_RestrictedStockMember_3948" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_3947" xlink:to="Locator_us-gaap_RestrictedStockMember_3948" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="Locator_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_3931" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="Locator_us-gaap_StatementClassOfStockAxis_3932" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_3931" xlink:to="Locator_us-gaap_StatementClassOfStockAxis_3932" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3975" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityNoteStockSplitConversionRatio1" xlink:label="Locator_us-gaap_StockholdersEquityNoteStockSplitConversionRatio1_3976" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_3975" xlink:to="Locator_us-gaap_StockholdersEquityNoteStockSplitConversionRatio1_3976" order="14.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/EquityBasedAndOtherCompensationPlansScheduleOfStockOptionsValuationAssumptionsDetails">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4011" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_4012" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4011" xlink:to="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_4012" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4013" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1" xlink:label="Locator_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_4014" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4013" xlink:to="Locator_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_4014" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4015" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_4016" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4015" xlink:to="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_4016" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4017" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_4018" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4017" xlink:to="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_4018" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4019" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="Locator_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_4020" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4019" xlink:to="Locator_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_4020" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="Locator_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_4021" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis" xlink:label="Locator_us-gaap_AwardTypeAxis_4022" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_4021" xlink:to="Locator_us-gaap_AwardTypeAxis_4022" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis" xlink:label="Locator_us-gaap_AwardTypeAxis_4023" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_4024" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_AwardTypeAxis_4023" xlink:to="Locator_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_4024" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis" xlink:label="Locator_us-gaap_AwardTypeAxis_4025" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_4026" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_us-gaap_AwardTypeAxis_4025" xlink:to="Locator_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_4026" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_4027" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockOptionMember" xlink:label="Locator_us-gaap_EmployeeStockOptionMember_4028" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_4027" xlink:to="Locator_us-gaap_EmployeeStockOptionMember_4028" order="1.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/EquityBasedAndOtherCompensationPlansScheduleOfStockOptionsActivityDetails">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="Locator_us-gaap_StatementClassOfStockAxis_4071" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_4072" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_StatementClassOfStockAxis_4071" xlink:to="Locator_us-gaap_ClassOfStockDomain_4072" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_4073" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassAMember" xlink:label="Locator_us-gaap_CommonClassAMember_4074" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockDomain_4073" xlink:to="Locator_us-gaap_CommonClassAMember_4074" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4075" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="Locator_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_4076" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4075" xlink:to="Locator_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_4076" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="Locator_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_4077" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="Locator_us-gaap_StatementClassOfStockAxis_4078" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_4077" xlink:to="Locator_us-gaap_StatementClassOfStockAxis_4078" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4079" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityNoteStockSplitConversionRatio1" xlink:label="Locator_us-gaap_StockholdersEquityNoteStockSplitConversionRatio1_4080" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_4079" xlink:to="Locator_us-gaap_StockholdersEquityNoteStockSplitConversionRatio1_4080" order="1.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/PremisesAndEquipmentSummaryOfPremisesAndEquipmentDetails">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentLineItems" xlink:label="Locator_us-gaap_PropertyPlantAndEquipmentLineItems_4157" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentGross" xlink:label="Locator_us-gaap_PropertyPlantAndEquipmentGross_4158" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_PropertyPlantAndEquipmentLineItems_4157" xlink:to="Locator_us-gaap_PropertyPlantAndEquipmentGross_4158" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentLineItems" xlink:label="Locator_us-gaap_PropertyPlantAndEquipmentLineItems_4159" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" xlink:label="Locator_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_4160" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_PropertyPlantAndEquipmentLineItems_4159" xlink:to="Locator_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_4160" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentLineItems" xlink:label="Locator_us-gaap_PropertyPlantAndEquipmentLineItems_4161" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="Locator_us-gaap_PropertyPlantAndEquipmentNet_4162" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_PropertyPlantAndEquipmentLineItems_4161" xlink:to="Locator_us-gaap_PropertyPlantAndEquipmentNet_4162" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentLineItems" xlink:label="Locator_us-gaap_PropertyPlantAndEquipmentLineItems_4163" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable" xlink:label="Locator_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_4164" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_us-gaap_PropertyPlantAndEquipmentLineItems_4163" xlink:to="Locator_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_4164" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable" xlink:label="Locator_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_4165" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:label="Locator_us-gaap_PropertyPlantAndEquipmentByTypeAxis_4166" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_4165" xlink:to="Locator_us-gaap_PropertyPlantAndEquipmentByTypeAxis_4166" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:label="Locator_us-gaap_PropertyPlantAndEquipmentByTypeAxis_4167" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="Locator_us-gaap_PropertyPlantAndEquipmentTypeDomain_4168" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_PropertyPlantAndEquipmentByTypeAxis_4167" xlink:to="Locator_us-gaap_PropertyPlantAndEquipmentTypeDomain_4168" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:label="Locator_us-gaap_PropertyPlantAndEquipmentByTypeAxis_4169" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="Locator_us-gaap_PropertyPlantAndEquipmentTypeDomain_4170" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_us-gaap_PropertyPlantAndEquipmentByTypeAxis_4169" xlink:to="Locator_us-gaap_PropertyPlantAndEquipmentTypeDomain_4170" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="Locator_us-gaap_PropertyPlantAndEquipmentTypeDomain_4171" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LandMember" xlink:label="Locator_us-gaap_LandMember_4172" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_PropertyPlantAndEquipmentTypeDomain_4171" xlink:to="Locator_us-gaap_LandMember_4172" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="Locator_us-gaap_PropertyPlantAndEquipmentTypeDomain_4173" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BuildingMember" xlink:label="Locator_us-gaap_BuildingMember_4174" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_PropertyPlantAndEquipmentTypeDomain_4173" xlink:to="Locator_us-gaap_BuildingMember_4174" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="Locator_us-gaap_PropertyPlantAndEquipmentTypeDomain_4175" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FurnitureAndFixturesMember" xlink:label="Locator_us-gaap_FurnitureAndFixturesMember_4176" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_PropertyPlantAndEquipmentTypeDomain_4175" xlink:to="Locator_us-gaap_FurnitureAndFixturesMember_4176" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="Locator_us-gaap_PropertyPlantAndEquipmentTypeDomain_4177" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComputerEquipmentMember" xlink:label="Locator_us-gaap_ComputerEquipmentMember_4178" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_PropertyPlantAndEquipmentTypeDomain_4177" xlink:to="Locator_us-gaap_ComputerEquipmentMember_4178" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="Locator_us-gaap_PropertyPlantAndEquipmentTypeDomain_4179" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeaseholdImprovementsMember" xlink:label="Locator_us-gaap_LeaseholdImprovementsMember_4180" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_PropertyPlantAndEquipmentTypeDomain_4179" xlink:to="Locator_us-gaap_LeaseholdImprovementsMember_4180" order="5.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/PremisesAndEquipmentNarrativeDetails">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentLineItems" xlink:label="Locator_us-gaap_PropertyPlantAndEquipmentLineItems_4203" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable" xlink:label="Locator_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_4204" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_us-gaap_PropertyPlantAndEquipmentLineItems_4203" xlink:to="Locator_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_4204" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable" xlink:label="Locator_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_4205" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:label="Locator_us-gaap_PropertyPlantAndEquipmentByTypeAxis_4206" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_4205" xlink:to="Locator_us-gaap_PropertyPlantAndEquipmentByTypeAxis_4206" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:label="Locator_us-gaap_PropertyPlantAndEquipmentByTypeAxis_4207" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="Locator_us-gaap_PropertyPlantAndEquipmentTypeDomain_4208" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_PropertyPlantAndEquipmentByTypeAxis_4207" xlink:to="Locator_us-gaap_PropertyPlantAndEquipmentTypeDomain_4208" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="Locator_us-gaap_PropertyPlantAndEquipmentTypeDomain_4209" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_BranchSaleAndRelocationMember" xlink:label="Locator_uscb_BranchSaleAndRelocationMember_4210" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_PropertyPlantAndEquipmentTypeDomain_4209" xlink:to="Locator_uscb_BranchSaleAndRelocationMember_4210" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentLineItems" xlink:label="Locator_us-gaap_PropertyPlantAndEquipmentLineItems_4211" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DepreciationDepletionAndAmortization" xlink:label="Locator_us-gaap_DepreciationDepletionAndAmortization_4212" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_PropertyPlantAndEquipmentLineItems_4211" xlink:to="Locator_us-gaap_DepreciationDepletionAndAmortization_4212" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentLineItems" xlink:label="Locator_us-gaap_PropertyPlantAndEquipmentLineItems_4213" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentDisposals" xlink:label="Locator_us-gaap_PropertyPlantAndEquipmentDisposals_4214" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_PropertyPlantAndEquipmentLineItems_4213" xlink:to="Locator_us-gaap_PropertyPlantAndEquipmentDisposals_4214" order="2.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/BorrowingsScheduleOfFixedInterestRatesAndExpectedMaturitiesDetails">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentAxis" xlink:label="Locator_us-gaap_DebtInstrumentAxis_4297" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="Locator_us-gaap_DebtInstrumentNameDomain_4298" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_DebtInstrumentAxis_4297" xlink:to="Locator_us-gaap_DebtInstrumentNameDomain_4298" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="Locator_us-gaap_DebtInstrumentNameDomain_4299" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_FhlbInstrument1Member" xlink:label="Locator_uscb_FhlbInstrument1Member_4300" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_DebtInstrumentNameDomain_4299" xlink:to="Locator_uscb_FhlbInstrument1Member_4300" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="Locator_us-gaap_DebtInstrumentNameDomain_4301" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_FhlbInstrument2Member" xlink:label="Locator_uscb_FhlbInstrument2Member_4302" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_DebtInstrumentNameDomain_4301" xlink:to="Locator_uscb_FhlbInstrument2Member_4302" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="Locator_us-gaap_DebtInstrumentNameDomain_4303" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_FhlbInstrument3Member" xlink:label="Locator_uscb_FhlbInstrument3Member_4304" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_DebtInstrumentNameDomain_4303" xlink:to="Locator_uscb_FhlbInstrument3Member_4304" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="Locator_us-gaap_DebtInstrumentNameDomain_4305" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_FhlbInstrument4Member" xlink:label="Locator_uscb_FhlbInstrument4Member_4306" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_DebtInstrumentNameDomain_4305" xlink:to="Locator_uscb_FhlbInstrument4Member_4306" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="Locator_us-gaap_DebtInstrumentNameDomain_4307" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_FhlbInstrument5Member" xlink:label="Locator_uscb_FhlbInstrument5Member_4308" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_DebtInstrumentNameDomain_4307" xlink:to="Locator_uscb_FhlbInstrument5Member_4308" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="Locator_us-gaap_DebtInstrumentNameDomain_4309" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_FhlbInstrument6Member" xlink:label="Locator_uscb_FhlbInstrument6Member_4310" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_DebtInstrumentNameDomain_4309" xlink:to="Locator_uscb_FhlbInstrument6Member_4310" order="6.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="Locator_us-gaap_DebtInstrumentNameDomain_4311" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_FhlbInstrument7Member" xlink:label="Locator_uscb_FhlbInstrument7Member_4312" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_DebtInstrumentNameDomain_4311" xlink:to="Locator_uscb_FhlbInstrument7Member_4312" order="7.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentLineItems" xlink:label="Locator_us-gaap_DebtInstrumentLineItems_4291" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentTable" xlink:label="Locator_us-gaap_DebtInstrumentTable_4292" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_us-gaap_DebtInstrumentLineItems_4291" xlink:to="Locator_us-gaap_DebtInstrumentTable_4292" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentTable" xlink:label="Locator_us-gaap_DebtInstrumentTable_4295" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentAxis" xlink:label="Locator_us-gaap_DebtInstrumentAxis_4296" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_DebtInstrumentTable_4295" xlink:to="Locator_us-gaap_DebtInstrumentAxis_4296" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentLineItems" xlink:label="Locator_us-gaap_DebtInstrumentLineItems_4313" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FederalHomeLoanBankAdvancesInterestRate" xlink:label="Locator_us-gaap_FederalHomeLoanBankAdvancesInterestRate_4314" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_DebtInstrumentLineItems_4313" xlink:to="Locator_us-gaap_FederalHomeLoanBankAdvancesInterestRate_4314" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentLineItems" xlink:label="Locator_us-gaap_DebtInstrumentLineItems_4315" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentMaturityDate" xlink:label="Locator_us-gaap_DebtInstrumentMaturityDate_4316" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_DebtInstrumentLineItems_4315" xlink:to="Locator_us-gaap_DebtInstrumentMaturityDate_4316" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentLineItems" xlink:label="Locator_us-gaap_DebtInstrumentLineItems_4317" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdvancesFromFederalHomeLoanBanks" xlink:label="Locator_us-gaap_AdvancesFromFederalHomeLoanBanks_4318" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_DebtInstrumentLineItems_4317" xlink:to="Locator_us-gaap_AdvancesFromFederalHomeLoanBanks_4318" order="3.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/ParentCompanyCondensedFinancialInformationScheduleOfCondensedBalanceSheetsDetails">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesAxis" xlink:label="Locator_srt_ConsolidatedEntitiesAxis_4385" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesDomain" xlink:label="Locator_srt_ConsolidatedEntitiesDomain_4386" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_srt_ConsolidatedEntitiesAxis_4385" xlink:to="Locator_srt_ConsolidatedEntitiesDomain_4386" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesAxis" xlink:label="Locator_srt_ConsolidatedEntitiesAxis_4403" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesDomain" xlink:label="Locator_srt_ConsolidatedEntitiesDomain_4404" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_srt_ConsolidatedEntitiesAxis_4403" xlink:to="Locator_srt_ConsolidatedEntitiesDomain_4404" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesDomain" xlink:label="Locator_srt_ConsolidatedEntitiesDomain_4387" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ParentCompanyMember" xlink:label="Locator_srt_ParentCompanyMember_4388" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_srt_ConsolidatedEntitiesDomain_4387" xlink:to="Locator_srt_ParentCompanyMember_4388" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CondensedBalanceSheetStatementsCaptionsLineItems" xlink:label="Locator_srt_CondensedBalanceSheetStatementsCaptionsLineItems_4373" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CondensedBalanceSheetStatementTable" xlink:label="Locator_srt_CondensedBalanceSheetStatementTable_4374" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_srt_CondensedBalanceSheetStatementsCaptionsLineItems_4373" xlink:to="Locator_srt_CondensedBalanceSheetStatementTable_4374" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CondensedBalanceSheetStatementTable" xlink:label="Locator_srt_CondensedBalanceSheetStatementTable_4383" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesAxis" xlink:label="Locator_srt_ConsolidatedEntitiesAxis_4384" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_srt_CondensedBalanceSheetStatementTable_4383" xlink:to="Locator_srt_ConsolidatedEntitiesAxis_4384" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CondensedBalanceSheetStatementsCaptionsLineItems" xlink:label="Locator_srt_CondensedBalanceSheetStatementsCaptionsLineItems_4389" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="Locator_us-gaap_CashAndCashEquivalentsAtCarryingValue_4390" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_srt_CondensedBalanceSheetStatementsCaptionsLineItems_4389" xlink:to="Locator_us-gaap_CashAndCashEquivalentsAtCarryingValue_4390" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CondensedBalanceSheetStatementsCaptionsLineItems" xlink:label="Locator_srt_CondensedBalanceSheetStatementsCaptionsLineItems_4391" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentsInAffiliatesSubsidiariesAssociatesAndJointVentures" xlink:label="Locator_us-gaap_InvestmentsInAffiliatesSubsidiariesAssociatesAndJointVentures_4392" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_srt_CondensedBalanceSheetStatementsCaptionsLineItems_4391" xlink:to="Locator_us-gaap_InvestmentsInAffiliatesSubsidiariesAssociatesAndJointVentures_4392" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CondensedBalanceSheetStatementsCaptionsLineItems" xlink:label="Locator_srt_CondensedBalanceSheetStatementsCaptionsLineItems_4393" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAssets" xlink:label="Locator_us-gaap_OtherAssets_4394" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_srt_CondensedBalanceSheetStatementsCaptionsLineItems_4393" xlink:to="Locator_us-gaap_OtherAssets_4394" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CondensedBalanceSheetStatementsCaptionsLineItems" xlink:label="Locator_srt_CondensedBalanceSheetStatementsCaptionsLineItems_4395" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Assets" xlink:label="Locator_us-gaap_Assets_4396" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_srt_CondensedBalanceSheetStatementsCaptionsLineItems_4395" xlink:to="Locator_us-gaap_Assets_4396" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CondensedBalanceSheetStatementsCaptionsLineItems" xlink:label="Locator_srt_CondensedBalanceSheetStatementsCaptionsLineItems_4397" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherLiabilities" xlink:label="Locator_us-gaap_OtherLiabilities_4398" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_srt_CondensedBalanceSheetStatementsCaptionsLineItems_4397" xlink:to="Locator_us-gaap_OtherLiabilities_4398" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CondensedBalanceSheetStatementsCaptionsLineItems" xlink:label="Locator_srt_CondensedBalanceSheetStatementsCaptionsLineItems_4399" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity" xlink:label="Locator_us-gaap_StockholdersEquity_4400" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_srt_CondensedBalanceSheetStatementsCaptionsLineItems_4399" xlink:to="Locator_us-gaap_StockholdersEquity_4400" order="6.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CondensedBalanceSheetStatementsCaptionsLineItems" xlink:label="Locator_srt_CondensedBalanceSheetStatementsCaptionsLineItems_4401" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="Locator_us-gaap_LiabilitiesAndStockholdersEquity_4402" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_srt_CondensedBalanceSheetStatementsCaptionsLineItems_4401" xlink:to="Locator_us-gaap_LiabilitiesAndStockholdersEquity_4402" order="7.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/SubsequentEventsNarrativeDetails">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="Locator_us-gaap_StatementClassOfStockAxis_4431" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_4432" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_StatementClassOfStockAxis_4431" xlink:to="Locator_us-gaap_ClassOfStockDomain_4432" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain" xlink:label="Locator_us-gaap_ClassOfStockDomain_4433" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonClassAMember" xlink:label="Locator_us-gaap_CommonClassAMember_4434" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_ClassOfStockDomain_4433" xlink:to="Locator_us-gaap_CommonClassAMember_4434" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="Locator_us-gaap_SubsequentEventTypeAxis_4427" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="Locator_us-gaap_SubsequentEventTypeDomain_4428" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_SubsequentEventTypeAxis_4427" xlink:to="Locator_us-gaap_SubsequentEventTypeDomain_4428" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="Locator_us-gaap_SubsequentEventTypeAxis_4439" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="Locator_us-gaap_SubsequentEventTypeDomain_4440" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_us-gaap_SubsequentEventTypeAxis_4439" xlink:to="Locator_us-gaap_SubsequentEventTypeDomain_4440" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="Locator_us-gaap_SubsequentEventTypeDomain_4429" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventMember" xlink:label="Locator_us-gaap_SubsequentEventMember_4430" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_SubsequentEventTypeDomain_4429" xlink:to="Locator_us-gaap_SubsequentEventMember_4430" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventLineItems" xlink:label="Locator_us-gaap_SubsequentEventLineItems_4419" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTable" xlink:label="Locator_us-gaap_SubsequentEventTable_4420" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_us-gaap_SubsequentEventLineItems_4419" xlink:to="Locator_us-gaap_SubsequentEventTable_4420" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTable" xlink:label="Locator_us-gaap_SubsequentEventTable_4423" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="Locator_us-gaap_SubsequentEventTypeAxis_4424" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_SubsequentEventTable_4423" xlink:to="Locator_us-gaap_SubsequentEventTypeAxis_4424" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTable" xlink:label="Locator_us-gaap_SubsequentEventTable_4425" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="Locator_us-gaap_StatementClassOfStockAxis_4426" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_SubsequentEventTable_4425" xlink:to="Locator_us-gaap_StatementClassOfStockAxis_4426" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventLineItems" xlink:label="Locator_us-gaap_SubsequentEventLineItems_4435" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TreasuryStockSharesAcquired" xlink:label="Locator_us-gaap_TreasuryStockSharesAcquired_4436" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_SubsequentEventLineItems_4435" xlink:to="Locator_us-gaap_TreasuryStockSharesAcquired_4436" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventLineItems" xlink:label="Locator_us-gaap_SubsequentEventLineItems_4437" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TreasuryStockAcquiredAverageCostPerShare" xlink:label="Locator_us-gaap_TreasuryStockAcquiredAverageCostPerShare_4438" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_SubsequentEventLineItems_4437" xlink:to="Locator_us-gaap_TreasuryStockAcquiredAverageCostPerShare_4438" order="2.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/ParentCompanyCondensedFinancialInformationScheduleOfIncomeStatementDetails">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesAxis" xlink:label="Locator_srt_ConsolidatedEntitiesAxis_4507" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesDomain" xlink:label="Locator_srt_ConsolidatedEntitiesDomain_4508" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_srt_ConsolidatedEntitiesAxis_4507" xlink:to="Locator_srt_ConsolidatedEntitiesDomain_4508" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesDomain" xlink:label="Locator_srt_ConsolidatedEntitiesDomain_4509" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ParentCompanyMember" xlink:label="Locator_srt_ParentCompanyMember_4510" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_srt_ConsolidatedEntitiesDomain_4509" xlink:to="Locator_srt_ParentCompanyMember_4510" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CondensedIncomeStatementsCaptionsLineItems" xlink:label="Locator_srt_CondensedIncomeStatementsCaptionsLineItems_4477" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CondensedIncomeStatementTable" xlink:label="Locator_srt_CondensedIncomeStatementTable_4478" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_srt_CondensedIncomeStatementsCaptionsLineItems_4477" xlink:to="Locator_srt_CondensedIncomeStatementTable_4478" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CondensedIncomeStatementTable" xlink:label="Locator_srt_CondensedIncomeStatementTable_4505" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesAxis" xlink:label="Locator_srt_ConsolidatedEntitiesAxis_4506" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_srt_CondensedIncomeStatementTable_4505" xlink:to="Locator_srt_ConsolidatedEntitiesAxis_4506" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CondensedIncomeStatementsCaptionsLineItems" xlink:label="Locator_srt_CondensedIncomeStatementsCaptionsLineItems_4511" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenuesAbstract" xlink:label="Locator_us-gaap_RevenuesAbstract_4512" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_srt_CondensedIncomeStatementsCaptionsLineItems_4511" xlink:to="Locator_us-gaap_RevenuesAbstract_4512" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenuesAbstract" xlink:label="Locator_us-gaap_RevenuesAbstract_4513" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashDividendsPaidToParentCompany" xlink:label="Locator_us-gaap_CashDividendsPaidToParentCompany_4514" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_RevenuesAbstract_4513" xlink:to="Locator_us-gaap_CashDividendsPaidToParentCompany_4514" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenuesAbstract" xlink:label="Locator_us-gaap_RevenuesAbstract_4515" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_ServiceFeesFromSubsidiaries" xlink:label="Locator_uscb_ServiceFeesFromSubsidiaries_4516" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_RevenuesAbstract_4515" xlink:to="Locator_uscb_ServiceFeesFromSubsidiaries_4516" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenuesAbstract" xlink:label="Locator_us-gaap_RevenuesAbstract_4517" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Revenues" xlink:label="Locator_us-gaap_Revenues_4518" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_RevenuesAbstract_4517" xlink:to="Locator_us-gaap_Revenues_4518" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CondensedIncomeStatementsCaptionsLineItems" xlink:label="Locator_srt_CondensedIncomeStatementsCaptionsLineItems_4519" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostsAndExpensesAbstract" xlink:label="Locator_us-gaap_CostsAndExpensesAbstract_4520" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_srt_CondensedIncomeStatementsCaptionsLineItems_4519" xlink:to="Locator_us-gaap_CostsAndExpensesAbstract_4520" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostsAndExpensesAbstract" xlink:label="Locator_us-gaap_CostsAndExpensesAbstract_4521" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LaborAndRelatedExpense" xlink:label="Locator_us-gaap_LaborAndRelatedExpense_4522" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_CostsAndExpensesAbstract_4521" xlink:to="Locator_us-gaap_LaborAndRelatedExpense_4522" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostsAndExpensesAbstract" xlink:label="Locator_us-gaap_CostsAndExpensesAbstract_4523" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostsAndExpenses" xlink:label="Locator_us-gaap_CostsAndExpenses_4524" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_CostsAndExpensesAbstract_4523" xlink:to="Locator_us-gaap_CostsAndExpenses_4524" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CondensedIncomeStatementsCaptionsLineItems" xlink:label="Locator_srt_CondensedIncomeStatementsCaptionsLineItems_4525" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest" xlink:label="Locator_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_4526" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_srt_CondensedIncomeStatementsCaptionsLineItems_4525" xlink:to="Locator_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_4526" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CondensedIncomeStatementsCaptionsLineItems" xlink:label="Locator_srt_CondensedIncomeStatementsCaptionsLineItems_4527" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxExpenseBenefit" xlink:label="Locator_us-gaap_IncomeTaxExpenseBenefit_4528" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_srt_CondensedIncomeStatementsCaptionsLineItems_4527" xlink:to="Locator_us-gaap_IncomeTaxExpenseBenefit_4528" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CondensedIncomeStatementsCaptionsLineItems" xlink:label="Locator_srt_CondensedIncomeStatementsCaptionsLineItems_4529" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromSubsidiariesNetOfTax" xlink:label="Locator_us-gaap_IncomeLossFromSubsidiariesNetOfTax_4530" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_srt_CondensedIncomeStatementsCaptionsLineItems_4529" xlink:to="Locator_us-gaap_IncomeLossFromSubsidiariesNetOfTax_4530" order="5.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CondensedIncomeStatementsCaptionsLineItems" xlink:label="Locator_srt_CondensedIncomeStatementsCaptionsLineItems_4531" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss" xlink:label="Locator_us-gaap_NetIncomeLoss_4532" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_srt_CondensedIncomeStatementsCaptionsLineItems_4531" xlink:to="Locator_us-gaap_NetIncomeLoss_4532" order="6.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/ParentCompanyCondensedFinancialInformationScheduleOfCashFlowDetails">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesAxis" xlink:label="Locator_srt_ConsolidatedEntitiesAxis_4603" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesDomain" xlink:label="Locator_srt_ConsolidatedEntitiesDomain_4604" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_srt_ConsolidatedEntitiesAxis_4603" xlink:to="Locator_srt_ConsolidatedEntitiesDomain_4604" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesDomain" xlink:label="Locator_srt_ConsolidatedEntitiesDomain_4605" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ParentCompanyMember" xlink:label="Locator_srt_ParentCompanyMember_4606" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_srt_ConsolidatedEntitiesDomain_4605" xlink:to="Locator_srt_ParentCompanyMember_4606" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_4609" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss" xlink:label="Locator_us-gaap_NetIncomeLoss_4610" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_4609" xlink:to="Locator_us-gaap_NetIncomeLoss_4610" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_4611" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeLossFromSubsidiariesNetOfTax" xlink:label="Locator_us-gaap_IncomeLossFromSubsidiariesNetOfTax_4612" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_4611" xlink:to="Locator_us-gaap_IncomeLossFromSubsidiariesNetOfTax_4612" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_4613" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherOperatingActivitiesCashFlowStatement" xlink:label="Locator_us-gaap_OtherOperatingActivitiesCashFlowStatement_4614" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_4613" xlink:to="Locator_us-gaap_OtherOperatingActivitiesCashFlowStatement_4614" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_4615" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInOperatingActivities_4616" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_4615" xlink:to="Locator_us-gaap_NetCashProvidedByUsedInOperatingActivities_4616" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_4619" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireBusinessesAndInterestInAffiliates" xlink:label="Locator_us-gaap_PaymentsToAcquireBusinessesAndInterestInAffiliates_4620" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_4619" xlink:to="Locator_us-gaap_PaymentsToAcquireBusinessesAndInterestInAffiliates_4620" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_4621" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsForProceedsFromOtherInvestingActivities" xlink:label="Locator_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_4622" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_4621" xlink:to="Locator_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_4622" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_4623" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivities_4624" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_4623" xlink:to="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivities_4624" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_4627" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsOfDividends" xlink:label="Locator_us-gaap_PaymentsOfDividends_4628" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_4627" xlink:to="Locator_us-gaap_PaymentsOfDividends_4628" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_4629" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromStockOptionsExercised" xlink:label="Locator_us-gaap_ProceedsFromStockOptionsExercised_4630" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_4629" xlink:to="Locator_us-gaap_ProceedsFromStockOptionsExercised_4630" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_4631" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsForRepurchaseOfEquity" xlink:label="Locator_us-gaap_PaymentsForRepurchaseOfEquity_4632" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_4631" xlink:to="Locator_us-gaap_PaymentsForRepurchaseOfEquity_4632" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_4633" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInFinancingActivities_4634" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_4633" xlink:to="Locator_us-gaap_NetCashProvidedByUsedInFinancingActivities_4634" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CondensedCashFlowStatementsCaptionsLineItems" xlink:label="Locator_srt_CondensedCashFlowStatementsCaptionsLineItems_4555" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CondensedCashFlowStatementTable" xlink:label="Locator_srt_CondensedCashFlowStatementTable_4556" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_srt_CondensedCashFlowStatementsCaptionsLineItems_4555" xlink:to="Locator_srt_CondensedCashFlowStatementTable_4556" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CondensedCashFlowStatementTable" xlink:label="Locator_srt_CondensedCashFlowStatementTable_4601" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ConsolidatedEntitiesAxis" xlink:label="Locator_srt_ConsolidatedEntitiesAxis_4602" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_srt_CondensedCashFlowStatementTable_4601" xlink:to="Locator_srt_ConsolidatedEntitiesAxis_4602" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CondensedCashFlowStatementsCaptionsLineItems" xlink:label="Locator_srt_CondensedCashFlowStatementsCaptionsLineItems_4607" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_4608" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_srt_CondensedCashFlowStatementsCaptionsLineItems_4607" xlink:to="Locator_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_4608" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CondensedCashFlowStatementsCaptionsLineItems" xlink:label="Locator_srt_CondensedCashFlowStatementsCaptionsLineItems_4617" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_4618" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_srt_CondensedCashFlowStatementsCaptionsLineItems_4617" xlink:to="Locator_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_4618" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CondensedCashFlowStatementsCaptionsLineItems" xlink:label="Locator_srt_CondensedCashFlowStatementsCaptionsLineItems_4625" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:label="Locator_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_4626" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_srt_CondensedCashFlowStatementsCaptionsLineItems_4625" xlink:to="Locator_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_4626" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CondensedCashFlowStatementsCaptionsLineItems" xlink:label="Locator_srt_CondensedCashFlowStatementsCaptionsLineItems_4635" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect" xlink:label="Locator_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_4636" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_srt_CondensedCashFlowStatementsCaptionsLineItems_4635" xlink:to="Locator_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_4636" order="4.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CondensedCashFlowStatementsCaptionsLineItems" xlink:label="Locator_srt_CondensedCashFlowStatementsCaptionsLineItems_4637" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:label="Locator_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_4638" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_srt_CondensedCashFlowStatementsCaptionsLineItems_4637" xlink:to="Locator_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_4638" order="5.0" />
    </definitionLink>
    <definitionLink xlink:type="extended" xlink:role="http://www.uscentury.com/role/RelatedPartyTransactionsNarrativeDetails">
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionDomain" xlink:label="Locator_us-gaap_RelatedPartyTransactionDomain_4665" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_PurchaseOfLoanMember" xlink:label="Locator_uscb_PurchaseOfLoanMember_4666" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_RelatedPartyTransactionDomain_4665" xlink:to="Locator_uscb_PurchaseOfLoanMember_4666" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionDomain" xlink:label="Locator_us-gaap_RelatedPartyTransactionDomain_4667" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_ParticipationInLoansMember" xlink:label="Locator_uscb_ParticipationInLoansMember_4668" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_RelatedPartyTransactionDomain_4667" xlink:to="Locator_uscb_ParticipationInLoansMember_4668" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyDomain" xlink:label="Locator_us-gaap_RelatedPartyDomain_4671" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_AuxiliorCapitalPartnersIncMember" xlink:label="Locator_uscb_AuxiliorCapitalPartnersIncMember_4672" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_RelatedPartyDomain_4671" xlink:to="Locator_uscb_AuxiliorCapitalPartnersIncMember_4672" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyDomain" xlink:label="Locator_us-gaap_RelatedPartyDomain_4673" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_DirectorAnotherInsuredFinancialInstitutionMember" xlink:label="Locator_uscb_DirectorAnotherInsuredFinancialInstitutionMember_4674" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_RelatedPartyDomain_4673" xlink:to="Locator_uscb_DirectorAnotherInsuredFinancialInstitutionMember_4674" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionLineItems" xlink:label="Locator_us-gaap_RelatedPartyTransactionLineItems_4657" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:label="Locator_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_4658" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="Locator_us-gaap_RelatedPartyTransactionLineItems_4657" xlink:to="Locator_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_4658" order="-1.0" xbrldt:contextElement="segment" xbrldt:closed="true" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:label="Locator_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_4659" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:label="Locator_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_4660" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_4659" xlink:to="Locator_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_4660" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:label="Locator_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_4663" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyDomain" xlink:label="Locator_us-gaap_RelatedPartyDomain_4664" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_4663" xlink:to="Locator_us-gaap_RelatedPartyDomain_4664" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:label="Locator_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_4683" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyDomain" xlink:label="Locator_us-gaap_RelatedPartyDomain_4684" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_4683" xlink:to="Locator_us-gaap_RelatedPartyDomain_4684" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable" xlink:label="Locator_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_4661" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionAxis" xlink:label="Locator_us-gaap_RelatedPartyTransactionAxis_4662" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="Locator_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_4661" xlink:to="Locator_us-gaap_RelatedPartyTransactionAxis_4662" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionAxis" xlink:label="Locator_us-gaap_RelatedPartyTransactionAxis_4669" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionDomain" xlink:label="Locator_us-gaap_RelatedPartyTransactionDomain_4670" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="Locator_us-gaap_RelatedPartyTransactionAxis_4669" xlink:to="Locator_us-gaap_RelatedPartyTransactionDomain_4670" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionAxis" xlink:label="Locator_us-gaap_RelatedPartyTransactionAxis_4685" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionDomain" xlink:label="Locator_us-gaap_RelatedPartyTransactionDomain_4686" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="Locator_us-gaap_RelatedPartyTransactionAxis_4685" xlink:to="Locator_us-gaap_RelatedPartyTransactionDomain_4686" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionLineItems" xlink:label="Locator_us-gaap_RelatedPartyTransactionLineItems_4675" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionAmountsOfTransaction" xlink:label="Locator_us-gaap_RelatedPartyTransactionAmountsOfTransaction_4676" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_RelatedPartyTransactionLineItems_4675" xlink:to="Locator_us-gaap_RelatedPartyTransactionAmountsOfTransaction_4676" order="1.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionLineItems" xlink:label="Locator_us-gaap_RelatedPartyTransactionLineItems_4677" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty" xlink:label="Locator_us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty_4678" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_RelatedPartyTransactionLineItems_4677" xlink:to="Locator_us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty_4678" order="2.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionLineItems" xlink:label="Locator_us-gaap_RelatedPartyTransactionLineItems_4679" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_NumberOfLoansParticipatedInRelatedPartyTransaction" xlink:label="Locator_uscb_NumberOfLoansParticipatedInRelatedPartyTransaction_4680" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_RelatedPartyTransactionLineItems_4679" xlink:to="Locator_uscb_NumberOfLoansParticipatedInRelatedPartyTransaction_4680" order="3.0" />
        <loc xlink:type="locator" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionLineItems" xlink:label="Locator_us-gaap_RelatedPartyTransactionLineItems_4681" />
        <loc xlink:type="locator" xlink:href="uscb-20221231.xsd#uscb_PercentOfPrincipalAmountOfAggregatePrincipalAmountOfTheLoans" xlink:label="Locator_uscb_PercentOfPrincipalAmountOfAggregatePrincipalAmountOfTheLoans_4682" />
        <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="Locator_us-gaap_RelatedPartyTransactionLineItems_4681" xlink:to="Locator_uscb_PercentOfPrincipalAmountOfAggregatePrincipalAmountOfTheLoans_4682" order="4.0" />
    </definitionLink>
</linkbase>
